Galaninski receptor 1

edit

Galaninski receptor 1
Identifikatori
Simboli	GALR1; GALNR; GALNR1
Vanjski ID	OMIM: 600377 MGI: 1096364 HomoloGene: 74396 IUPHAR: GAL1 GeneCards: GALR1 Gene
Ontologija gena Molekularna funkcija • aktivnost rodopsinu sličnog receptora • receptorska aktivnost • aktivnost galaninskog receptora Celularna komponenta • ćelijska membrana • integralno sa membranom Biološki proces • jonski transport • prenos signala • aktivnost negativne regulacije adenilat ciklaze • neuropeptidni signalni put • sinaptički prenos • varenje
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	2587	14427
Ensembl	ENSG00000166573	ENSMUSG00000024553
UniProt	P47211	P56479
RefSeq (mRNA)	NM_001480	NM_008082
RefSeq (protein)	NP_001471	NP_032108
Lokacija (UCSC)	Chr 18: 73.09 - 73.11 Mb	Chr 18: 82.53 - 82.54 Mb
PubMed pretraga	[1]	[2]

Galaninski receptor 1 (GAL₁) je G protein spregnuti receptor kodiran GALR1 genom.^[1]

Neuropeptid galanin izaziva niz bioloških efekata putem interakcija sa specifičnim G-protein spregnutim receptorima. Galaninski receptori su sedam-transmembranski proteini za koje je pokazano da aktiviraju niz intracelularnih puteva sekundarnih glasnika. GALR1 inhibira adenilat ciklazu preko G proteina iz Gi/Go familije. GALR1 je široko izražen u mozgu i kičmenoj moždini, kao i na perifernim lokacijama poput tankih creva i srca.^[1]

Povezano

• Galaninski receptor

Reference

1. „Entrez Gene: GALR1 galanin receptor 1”. 

Literatura

• Habert-Ortoli E, Amiranoff B, Loquet I, et al. (1994). „Molecular cloning of a functional human galanin receptor.”. Proc. Natl. Acad. Sci. U.S.A. 91 (21): 9780–3. DOI:10.1073/pnas.91.21.9780. PMC 44900. PMID 7524088. 
• Walli R, Schäfer H, Morys-Wortmann C, et al. (1995). „Identification and biochemical characterization of the human brain galanin receptor.”. J. Mol. Endocrinol. 13 (3): 347–56. DOI:10.1677/jme.0.0130347. PMID 7534460. 
• Kask K, Berthold M, Kahl U, et al. (1996). „Delineation of the peptide binding site of the human galanin receptor.”. EMBO J. 15 (2): 236–44. PMC 449938. PMID 8617199. 
• Lorimer DD, Benya RV (1996). „Cloning and quantification of galanin-1 receptor expression by mucosal cells lining the human gastrointestinal tract.”. Biochem. Biophys. Res. Commun. 222 (2): 379–85. DOI:10.1006/bbrc.1996.0752. PMID 8670213. 
• Nicholl J, Kofler B, Sutherland GR, et al. (1997). „Assignment of the gene encoding human galanin receptor (GALNR) to 18q23 by in situ hybridization.”. Genomics 30 (3): 629–30. DOI:10.1006/geno.1995.1292. PMID 8825658. 
• Sullivan KA, Shiao LL, Cascieri MA (1997). „Pharmacological characterization and tissue distribution of the human and rat GALR1 receptors.”. Biochem. Biophys. Res. Commun. 233 (3): 823–8. DOI:10.1006/bbrc.1997.6542. PMID 9168941. 
• Jacoby AS, Webb GC, Liu ML, et al. (1998). „Structural organization of the mouse and human GALR1 galanin receptor genes (Galnr and GALNR) and chromosomal localization of the mouse gene.”. Genomics 45 (3): 496–508. DOI:10.1006/geno.1997.4960. PMID 9367674. 
• Lorimer DD, Matkowskj K, Benya RV (1998). „Cloning, chromosomal location, and transcriptional regulation of the human galanin-1 receptor gene (GALN1R).”. Biochem. Biophys. Res. Commun. 241 (2): 558–64. DOI:10.1006/bbrc.1997.7838. PMID 9425310. 
• Fitzgerald LW, Patterson JP, Conklin DS, et al. (1998). „Pharmacological and biochemical characterization of a recombinant human galanin GALR1 receptor: agonist character of chimeric galanin peptides.”. J. Pharmacol. Exp. Ther. 287 (2): 448–56. PMID 9808667. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Henson BS, Neubig RR, Jang I, et al. (2005). „Galanin receptor 1 has anti-proliferative effects in oral squamous cell carcinoma.”. J. Biol. Chem. 280 (24): 22564–71. DOI:10.1074/jbc.M414589200. PMID 15767248. 
• Schäuble N, Reichwald K, Grassl W, et al. (2005). „Human galanin (GAL) and galanin 1 receptor (GALR1) variations are not involved in fat intake and early onset obesity.”. J. Nutr. 135 (6): 1387–92. PMID 15930442. 
• Belfer I, Hipp H, Bollettino A, et al. (2007). „Alcoholism is associated with GALR3 but not two other galanin receptor genes.”. Genes, Brain and Behavior 6 (5): 473–81. DOI:10.1111/j.1601-183X.2006.00275.x. PMID 17083333. 

Vanjske veze

• „Galanin Receptors: GAL₁”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.