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Satavaptan
Satavaptan
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| (IUPAC) ime
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| N-(tert-butyl)-4[(1s,4s)-5'-ethoxy-4-(2-morpholin-4-ylethoxy)-2'-oxospiro[cyclohexane-1,3'-indol]-1'(2'H)-yl]sulfonyl3-methoxybenzamide
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| Klinički podaci
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| Identifikatori
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| CAS broj
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185913-78-4
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| ATC kod
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nije dodeljen
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| PubChem[1][2]
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9810773
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| Hemijski podaci
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| Formula
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C33H45N3O8S
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| Mol. masa
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643.789
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| SMILES
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eMolekuli & PubHem
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| InChI |
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InChI=1S/C33H45N3O8S.C4H4O4/c1-6-43-25-8-9-27-26(22-25)33(13-11-24(12-14-33)44-20-17-35-15-18-42-19-16-35)31(38)36(27)45(39,40)29-10-7-23(21-28(29)41-5)30(37)34-32(2,3)4;5-3(6)1-2-4(7)8/h7-10,21-22,24H,6,11-20H2,1-5H3,(H,34,37);1-2H,(H,5,6)(H,7,8)/b;2-1+  Y
Key: FVYUFJMPTILYEX-WLHGVMLRSA-N Y |
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| Farmakoinformacioni podaci
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| Trudnoća
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?
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| Pravni status
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Satavaptan (INN; SR121463, Aquilda) je antagonist vazopresin-2 receptora[3] koji se ispituje za potencijalnu primenu u lečenju hiponatremije. On se takođe ispituje za premenu u tretmanima ascita.[4] Ovaj lek je razvila kompanija Sanofi-Aventis.
Literatura
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Soupart A, Gross P, Legros JJ, et al. (November 2006). „Successful long-term treatment of hyponatremia in syndrome of inappropriate antidiuretic hormone secretion with satavaptan (SR121463B), an orally active nonpeptide vasopressin V2-receptor antagonist”. Clin J Am Soc Nephrol 1 (6): 1154–60. DOI:10.2215/CJN.00160106. PMID 17699341.
- ↑ Ginès P, Wong F, Watson H, Milutinovic S, Ruiz Del Arbol L, Olteanu D (February 2008). „Effects of satavaptan, a selective vasopressin V(2) receptor antagonist, on ascites and serum sodium in cirrhosis with hyponatremia: A randomized trial”. Hepatology 48 (1): 204–13. DOI:10.1002/hep.22293. PMID 18508290.
Vanjske veze
Šablon:Diuretici
Šablon:Neuropeptidni ligandi
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