Leukotrien B4

Leukotrien B4
Identifikacija
CAS registarski broj 71160-24-2
PubChem[1][2] 169
MeSH Leukotriene+B4
Svojstva
Molekulska formula C20H32O4
Molarna masa 336.466



Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

Leukotrien B4 je leukotrien koji učestvuje u inflamacionim procesima. Njega proizvode leukociti u odgovoru na inflamatorne posrednike. On ima sposobnost indukovanja adhezije i aktivacije leukocita na endotelu, čime im omogućava da se vežu za i da pređu u tkivo[3]. U neutrofilima, on je isto tako potentan hemoatraktant, i ima sposobnost indukovanja formiranja reaktivnih oblika kiseonika, i oslobađanja enzima lizozoma iz tih ćelija[3].

Sinteza eikosanoida. (Leukotrieni su sa desne strane.)

Reference

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. 3,0 3,1 Cotran; Kumar, Collins (1994). Robbins Pathologic Basis of Disease. Philadelphia: W.B Saunders Company. ISBN 0-7216-7335-X. 

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