Travoprost

Travoprost

(IUPAC) ime
propan-2-il 7-[3,5-dihidroksi-2-[3-hidroksi-4-[3-(trifluorometil) fenoksi]-but-1-enil]-ciklopentil]hept-5-enoat
Klinički podaci
Robne marke	Travatan
AHFS/Drugs.com	Monografija
MedlinePlus	a602027
Identifikatori
CAS broj	157283-68-6
ATC kod	S01EE04
PubChem[1][2]	5282226
DrugBank	DB00287
ChemSpider[3]	4445407
UNII	WJ68R08KX9^Y
KEGG[4]	D01964^Y
ChEBI	CHEBI:746859^Y
ChEMBL[5]	CHEMBL1200799^Y
Hemijski podaci
Formula	C26H35F3O6
Mol. masa	500,548 g/mol
SMILES	eMolekuli & PubHem
InChI InChI=1S/C26H35F3O6/c1-17(2)35-25(33)11-6-4-3-5-10-21-22(24(32)15-23(21)31)13-12-19(30)16-34-20-9-7-8-18(14-20)26(27,28)29/h3,5,7-9,12-14,17,19,21-24,30-32H,4,6,10-11,15-16H2,1-2H3/b5-3-,13-12+/t19-,21-,22-,23+,24-/m1/s1^Y Key: MKPLKVHSHYCHOC-AHTXBMBWSA-N^Y
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	Rx only (US)
Način primene	Topikalno (kapi za oči)

Travoprost (Travatan, Travatan Z, Travo-Z) ofthalmički rastvor je topikalni lek koji se koristi za kontrolu progresije glaukoma ili okularne hipertenzije. On deluje tako što redukuje intraokularni pritisak. On je sintetički prostaglandinski analog (specifičnije, analog prostaglandina F_2α)^[6][7] koji uvećava odliv fluida iz očiju.^[8]

Reference

1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
4. Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
6. Alcon Laboratories, Inc. (September 2011). „TRAVATAN - travoprost solution”. DailyMed. Bethesda, MD: U.S. National Library of Medicine. Pristupljeno 30. 09. 2011. 
7. Alcon Laboratories, Inc. (September 2011). „TRAVATAN Z (travoprost) solution”. DailyMed. Bethesda, MD: U.S. National Library of Medicine. Pristupljeno 30. 09. 2011. 
8. AHFS Consumer Medication Information (01. 01. 2011.). „Travoprost Ophthalmic”. MedlinePlus. Bethesda, MD: U.S. National Library of Medicine. Pristupljeno 30. 09. 2011. 

Vanjske veze