P2RY8

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Purinski receptor P2Y, G-protein spregnuti, 8
Identifikatori
Simboli	P2RY8; MGC50878; P2Y8
Vanjski ID	OMIM: 300525 HomoloGene: 65345 IUPHAR: P2RY8 GeneCards: P2RY8 Gene
Ontologija gena Molekularna funkcija • aktivnost rodopsinu-sličnog receptora • receptorska aktivnost • aktivnost purinskog nukleotidnog receptora, G-protein spregnutog Celularna komponenta • membrana • integralno sa membranom Biološki proces • prenos signala • signalni put G-protein spregnutog receptora
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	286530	n/a
Ensembl	ENSG00000182162	n/a
UniProt	Q86VZ1	n/a
RefSeq (mRNA)	NM_178129	n/a
RefSeq (protein)	NP_835230	n/a
Lokacija (UCSC)	Chr X: 1.54 - 1.62 Mb	n/a
PubMed pretraga	[1]	n/a

P2RY8 (P2Y purinoceptor 8) je protein je protein koji je kod ljudi kodiran P2RY8 genom.^[1][2]

Protein kodiran ovim genom pripada familiji G-protein spregnutih receptora, koji su preferentno aktivirani nukleotidima adenozina i uridina. Ove gen je umereno izražen u nediferenciranim HL60 ćelijama. On je lociran na hromozomima X i Y.^[2]

Povezano

• P2Y receptor

Reference

1. Adrian K, Bernhard MK, Breitinger HG, Ogilvie A (Sep 2000). „Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells”. Biochim Biophys Acta 1492 (1): 127–38. PMID 11004484. 
2. „Entrez Gene: P2RY8 purinergic receptor P2Y, G-protein coupled, 8”. 

Literatura

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039. 
• Cantagrel V, Lossi AM, Boulanger S, et al. (2005). „Disruption of a new X linked gene highly expressed in brain in a family with two mentally retarded males.”. J. Med. Genet. 41 (10): 736–42. DOI:10.1136/jmg.2004.021626. PMC 1735597. PMID 15466006. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). „The DNA sequence of the human X chromosome.”. Nature 434 (7031): 325–37. DOI:10.1038/nature03440. PMC 2665286. PMID 15772651. 
• Fujiwara S, Yamashita Y, Choi YL, et al. (2007). „Transforming activity of purinergic receptor P2Y, G protein coupled, 8 revealed by retroviral expression screening.”. Leuk. Lymphoma 48 (5): 978–86. DOI:10.1080/10428190701225882. PMID 17487742. 
• Storlazzi CT, Albano F, Lo Cunsolo C, et al. (2007). „Upregulation of the SOX5 by promoter swapping with the P2RY8 gene in primary splenic follicular lymphoma.”. Leukemia 21 (10): 2221–5. DOI:10.1038/sj.leu.2404784. PMID 17554380.