5-HT1D receptor

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5-hidroksitriptaminski (serotoninski) receptor 1D
Identifikatori
Simboli	HTR1D; 5-HT1D; HT1DA; HTR1DA; HTRL; RDC4
Vanjski ID	OMIM: 182133 MGI: 96276 HomoloGene: 20240 IUPHAR: 5-HT1D GeneCards: HTR1D Gene
Ontologija gena Molekularna funkcija • aktivnost rodopsinu-sličnog receptora • receptorska aktivnost • aktivnost serotoninskog receptora Celularna komponenta • integralno sa ćelijskom membranom • membrana Biološki proces • prenos signala • G-proteinska signalizacija, spregnuta sa cikličnim nukleotidnim sekundarnim glasnikom • sinaptička transmisija
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	3352	15552
Ensembl	ENSG00000179546	ENSMUSG00000070687
UniProt	P28221	Q3ZB48
RefSeq (mRNA)	NM_000864	NM_008309
RefSeq (protein)	NP_000855	NP_032335
Lokacija (UCSC)	Chr 1: 23.39 - 23.39 Mb	Chr 4: 135.7 - 135.72 Mb
PubMed pretraga	[1]	[2]

5-HT_1D receptor (5-hidroksitriptaminski (serotoninski) receptor 1D, HTR1D) je 5-HT receptor. On je kodiran istoimenim genom.^[1] 5-HT_1D deluje na centralni nervni sistem, i utiče na kretanje i anksioznost. On takoše indukuje vaskularnu vazokonstrikciju u mozgu.

Ligandi

Agonisti

• 5-(Noniloksi)triptamin,^[2]
• sumatriptan (vazokonstriktor kod migraine)
• 5-Karboksamidotriptamin (5-CT)
• 5-(t-Butil)-N-metiltriptamin^[3]
• CP-286,601
• PNU-109,291 ((S)-3,4-Dihidro-1-[2-[4-(4-metoksifenil)-1-piperazinil]etil]-N-metil-1H-2-benzopiran-6-karboksamid)
• PNU-142,633 ((1S)-1-[2-[4-[4-(Aminokarbonil)fenil]-1-piperazinil]etil]-3,4-dihidro-N-metil-1H-2-benzopiran-6-karboksamid)
• GR-46611 (3-[3-(2-Dimetilaminoetil)-1H-indol-5-il]-N-(4-metoksibenzil)akrilamid)
• L-694,247 (2-[5-[3-(4-Metilsulfonilamino)benzil-1,2,4-oksadiazol-5-il]-1H-indol-3-il]etanamin)
• L-772,405

Antagonisti

• Ziprasidon (atipični antipsihotik)^[4]
• metiotepin (antipsihotik)
• johimbin (afrodizijak)
• metergolin
• ergotamin (vazokonstriktor kod migraine)
• BRL-15572
• GR-127,935 (mešoviti 5-HT_1B/1D antagonist)
• LY-310,762
• LY-367,642
• LY-456,219
• LY-456,220

Povezano

• 5-HT₁ receptor
• 5-HT receptor

Literatura

1. „Entrez Gene: HTR1D 5-hydroxytryptamine (serotonin) receptor 1D”. 
2. Glennon RA, Hong SS, Dukat M, Teitler M, Davis K (1994). „5-(Nonyloxy)tryptamine: a novel high-affinity 5-HT_1D beta serotonin receptor agonist”. J. Med. Chem. 37 (18): 2828–30. DOI:10.1021/jm00044a001. PMID 8071931. 
3. Xu, YC; Schaus, JM; Walker, C; Krushinski, J; Adham, N; Zgombick, JM; Liang, SX; Kohlman, DT i dr.. (1999). „N-Methyl-5-tert-butyltryptamine: A novel, highly potent 5-HT1D receptor agonist.”. Journal of medicinal chemistry 42 (3): 526–31. DOI:10.1021/jm9805945. PMID 9986723. 
4. „Essential psychopharmacology: neuroscientific basis and practical applications”. 

Dodatna literatura

• Hamblin MW, Metcalf MA, McGuffin RW, Karpells S (1992). „Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity.”. Biochem. Biophys. Res. Commun. 184 (2): 752–9. DOI:10.1016/0006-291X(92)90654-4. PMID 1315531. 
• Weinshank RL, Zgombick JM, Macchi MJ, et al. (1992). „Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta.”. Proc. Natl. Acad. Sci. U.S.A. 89 (8): 3630–4. DOI:10.1073/pnas.89.8.3630. PMC 48922. PMID 1565658. 
• Hamblin MW, Metcalf MA (1991). „Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor.”. Mol. Pharmacol. 40 (2): 143–8. PMID 1652050. 
• Libert F, Passage E, Parmentier M, et al. (1992). „Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor.”. Genomics 11 (1): 225–7. DOI:10.1016/0888-7543(91)90125-X. PMID 1662665. 
• Libert F, Parmentier M, Lefort A, et al. (1989). „Selective amplification and cloning of four new members of the G protein-coupled receptor family.”. Science 244 (4904): 569–72. DOI:10.1126/science.2541503. PMID 2541503. 
• Cargill M, Altshuler D, Ireland J, et al. (1999). „Characterization of single-nucleotide polymorphisms in coding regions of human genes.”. Nat. Genet. 22 (3): 231–8. DOI:10.1038/10290. PMID 10391209. 
• Salim K, Fenton T, Bacha J, et al. (2002). „Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation.”. J. Biol. Chem. 277 (18): 15482–5. DOI:10.1074/jbc.M201539200. PMID 11854302. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Bergen AW, van den Bree MB, Yeager M, et al. (2004). „Candidate genes for anorexia nervosa in the 1p33-36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa.”. Mol. Psychiatry 8 (4): 397–406. DOI:10.1038/sj.mp.4001318. PMID 12740597. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). „Towards a proteome-scale map of the human protein-protein interaction network.”. Nature 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514. 
• Gregory SG, Barlow KF, McLay KE, et al. (2006). „The DNA sequence and biological annotation of human chromosome 1.”. Nature 441 (7091): 315–21. DOI:10.1038/nature04727. PMID 16710414. 
• Li J, Zhang X, Wang Y, et al. (2007). „The serotonin 5-HT1D receptor gene and attention-deficit hyperactivity disorder in Chinese Han subjects.”. Am. J. Med. Genet. B Neuropsychiatr. Genet. 141 (8): 874–6. DOI:10.1002/ajmg.b.30364. PMID 17099886. 

Vanjske veze

• „5-HT_1D”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2012-02-22.