Kanabidiol

Kanabidiol

(IUPAC) ime
2-[(1R,6R)-6-izopropenil-3-metilcikloheks-2-en-1-il]-5-pentilbenzen-1,3-diol
Klinički podaci
AHFS/Drugs.com	Internacionalno ime leka
Identifikatori
CAS broj	13956-29-1
ATC kod	nije dodeljen
PubChem[1][2]	644019
DrugBank	none
ChemSpider[3]	24593618
UNII	19GBJ60SN5^Y
Hemijski podaci
Formula	C21H30O2
Mol. masa	314,46
SMILES	eMolekuli & PubHem
InChI InChI=1S/C21H30O2/c1-5-6-7-8-16-12-19(22)21(20(23)13-16)18-11-15(4)9-10-17(18)14(2)3/h9,12-13,17-18,22-23H,2,5-8,10-11H2,1,3-4H3/t17-,18+/m0/s1^Y Key: ZTGXAWYVTLUPDT-ZWKOTPCHSA-N^Y
Fizički podaci
Tačka topljenja	66 °C (151 °F)
Tačka ključanja	180 °C (356 °F) (Opseg: 160 °C-180 °C)[4]
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	Plan II (Kanada)

Kanabidiol (CBD) je kanabinoid prisutan u kanabisu. On je glavni sastojak biljke, koji sačinjava do 40% njenog ekstrakta.^[5]

On pokazuje sedativno dejstvo u testovima na životinjama.^[6] Neka istraživanja, međutim, indiciraju da CBD može da poveća budnost.^[7] On može da umanji brzinu uklanjanja THC-a iz tela, verovatno putem ometanja metabolizma THC-a u jetri.

Pokazano je da omanjuje konvulzije, inflamaciju, anksioznost, i mučninu, kao i da inhibira rast ćelija kancera.^[8] Nedavne studije su pokazale da je kanabidiol efektivan kao atipični antipsihotik u tretmanu šizofrenije.^[9] Ispitivanja su takođe pokazala da olakšava simptome distonije.^[10][11]

Novembera 2007. je objavljeno da CBD redukuje rast agresivnih ljudskih ćelija raka dojke in vitro i da umanjuje njihovu invazivnost.

References

1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
4. McPartland, JM; Russo, EB (2001). „Cannabis and Cannabis Extracts: Greater Than the Sum of Their Parts?” (PDF). Journal of Cannabis Therapeutics 1 (3/4): 103–132. 
5. Grlić, Ljubiša (1962). „A comparative study on some chemical and biological characteristics of various samples of cannabis resin”. Bulletin on Narcotics (United Nations Office on Drugs and Crime) (3): 37–46. 
6. Pickens JT (1981). „Sedative activity of cannabis in relation to its delta'-trans-tetrahydrocannabinol and cannabidiol content”. British Journal of Pharmacology 72 (4): 649–56. PMC 2071638. PMID 6269680. 
7. Nicholson, AN; C Turner, BM Stone, and PJ Robson (June 2004). „Effect of Delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults” (fee required). J Clin Psychopharmacol 24 (3): 305–13. DOI:10.1097/01.jcp.0000125688.05091.8f. ISSN 0271-0749. PMID 15118485. Arhivirano iz originala na datum 2011-07-18. Pristupljeno 2007-05-03. 
8. Mechoulam, R.; M. Peters, Murillo-Rodriguez (21 Aug 2007). „Cannabidiol - recent advances”. Chemistry & Biodiversity 4 (8): 1678–1692. DOI:10.1002/cbdv.200790147. PMID 17712814. ^{[mrtav link]}
9. Zuardi, A.W; J.A.S. Crippa, J.E.C. Hallak, F.A. Moreira, F.S. Guimarães (2006). „Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug” (PDF). Brazilian Journal of Medical and Biological Research 39 (4): 421–429. DOI:10.1590/S0100-879X2006000400001. PMID 16612464. 
10. Consroe, P.; Sandyk, R.; Snider, S. R. (1986). „Open label evaluation of cannabidiol in dystonic movement disorders”. The International journal of neuroscience 30 (4): 277–282. DOI:10.3109/00207458608985678. PMID 3793381. 
11. Snider, Stuart R.; Consroe, Paul (1985). „Beneficial and Adverse Effects of Cannabidiol in a Parkinson Patient with Sinemet-Induced Dystonic Dyskinesia”. Neurology (Suppl 1): 201. 

Povezano

• Kanabinoidi
• Kanabinoidni receptori
• Kanabis
• Medicincka marihuana

Vanjske veze

• Erowid Compounds found in Cannabis sativa