11-nor-9-karboksi-THC

11-nor-9-karboksi-THC
THC-11-oic acid molecule
(IUPAC) ime
1-hidroksi-6,6-dimetil-3-pentil-6a,7,8,10a-tetrahidrobenzo[c]hromen-9-karboksilna kiselina
Klinički podaci
Identifikatori
CAS broj 64280-14-4
ATC kod nije dodeljen
PubChem[1][2] 107885
ChemSpider[3] 97019
Hemijski podaci
Formula C21H28O4 
Mol. masa 344,445 g/mol
SMILES eMolekuli & PubHem
Farmakokinetički podaci
Bioraspoloživost varijabilna
Metabolizam varijabilan
Poluvreme eliminacije 5,2 do 6,2 dana[4]
Izlučivanje Variabilna
Farmakoinformacioni podaci
Trudnoća ?
Pravni status varijabilan
Način primene varijabilne

11-nor-9-karboksi-THC (11-nor-9-karboksi-delta-9-tetrahidrokanabinol, 11-COOH-THC, THC-COOH, THC-11-oic kiselina) je glavni sekundarni metabolit THC koji se formira u telu nakon konzumacije kanabisa.

11-COOH-THC se forma u telu oksidacijom aktivnog metabolita 11-hidroksi-THC posredstvom enzima jetre. On se zatim dalje metabolizuje putem konjugacije sa glukuronidom,[5] čimes se formira u vodi rastvorno jedinjenje, koje se lakše izlučuje iz tela.[6]

Reference

  1. ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. ↑ Δ9-Tetrahydrocannabinol (THC), 11-Hydroxy-THC, and 11-Nor-9-carboxy-THC Plasma Pharmacokinetics during and after Continuous High-Dose Oral THC
  5. ↑ Skopp, G; Pötsch, L (2002). „Stability of 11-nor-delta(9)-carboxy-tetrahydrocannabinol glucuronide in plasma and urine assessed by liquid chromatography-tandem mass spectrometry”. Clinical chemistry 48 (2): 301–6. PMID 11805011. 
  6. ↑ Law, B; Mason, PA; Moffat, AC; King, LJ (1984). „Confirmation of cannabis use by the analysis of delta 9-tetrahydrocannabinol metabolites in blood and urine by combined HPLC and RIA”. Journal of analytical toxicology 8 (1): 19–22. PMID 6323852. 

Šablon:Kanabinoidi

Read other articles:

吉野川市立山川中学校

吉野川市立山川中学校 北緯34度03分42秒 東経134度14分00秒 / 北緯34.061667度 東経134.233222度 / 34.061667; 134.233222座標: 北緯34度03分42秒 東経134度14分00秒 / 北緯34.061667度 東経134.233222度 / 34.061667; 134.233222過去の名称 徳島県麻植郡山川中学校国公私立の別 公立学校設置者 吉野川市校訓 自律・親和・創造設立年月日 1966年（昭和41年）4月1日共学・別

 

Distrito electoral federal 10 de Chihuahua

X Distrito Electoral Federal de Chihuahua(Suprimido) Distrito electoral federalCabecera distrital Cuauhtémoc(hasta 1997)Entidad Distrito electoral federal • País México México • Estado ChihuahuaEventos históricos   • Creación 1978[editar datos en Wikidata] El X Distrito Electoral Federal de Chihuahua fue un antiguo distrito electoral que existió en el estado mexicano de Chihuahua entre 1979 y 1997. Fue creado por la reforma política de 1977 que elev...

 

Тєрєхов Артем Віталійович

Артем Тєрєхов Особисті дані Повне ім'я Артем Віталійович Тєрєхов Народження 31 березня 1992(1992-03-31) (31 рік)   Іларіонове, Дніпропетровська область, Україна Зріст 189 см Вага 80 кг Громадянство  Україна Позиція захисник Інформація про клуб Поточний клуб ФСК «Маріуполь»

Pleon

Het pleon of abdomen zijn de achterlijfsomieten bij kreeftachtigen. Enkel bij mosselkreeftjes en Remipedia is dit lichaamsdeel niet aanwezig. Het telson wordt al[1] dan niet[2] tot het pleon gerekend. Het pleon bezit al dan niet extremiteiten. Bij vlokreeftjes (Amphipoda) en andere Malacostraca is het een onderdeel van het exoskelet. Het bestaat uit zes segmenten, waarvan de eerste drie, de pleonieten, het pleosoom vormen, elk met een paar tweetakkige pleopoden, en de laatste ...

 

Mille Gejl

Mille Gejl Datos personalesNombre completo Mille Gejl JensenNacimiento Dinamarca23 de septiembre de 1999 (24 años)Nacionalidad(es) DanesaAltura 1,75 m (5′ 9″)Carrera deportivaDeporte Fútbol femeninoClub profesionalDebut deportivo 2015(Varde IF)Club North Carolina CourageLiga National Women's Soccer LeaguePosición MediocampistaDorsal(es) 22Selección nacionalSelección DinamarcaDebut 21 de enero de 2019Dorsal(es) 17Part. (goles) 23 (7)Trayectoria Varde IF (-2015) Kol...

 

Berg (rheinländisches Adelsgeschlecht)

Wappen derer von Berg-Durffendal Berg oder Berge ist der Name eines erloschenen rheinländisches Adelsgeschlechts. Inhaltsverzeichnis 1 Geschichte 2 Wappen 3 Literatur 4 Einzelnachweise 5 Siehe auch 6 Weblinks Geschichte Die Familie zählt zum jülichen Uradel und hatte ihren Stammsitz in Dürffenthal bei Ülpenich. Mit Christian von Durffendale, mit dem auch die gesicherte Stammreihe beginnt, wurde das Geschlecht im Jahre 1357 erstmals urkundlich erwähnt.[1] Die Berg teilten sich be...

2024 Iranian Assembly of Experts election

This article relies largely or entirely on a single source. Please help improve this article by introducing citations to additional sources.Find sources: 2024 Iranian Assembly of Experts election – news · newspapers · books · scholar · JSTOR (December 2023) 2024 Iranian Assembly of Experts election is going to be held on March 1, 2024, with the elections of Islamic Consultative Majlis. Among notable candidates former president Hassan Rouhani has regist...

 

Hispaniolan trogon

Species of bird endemic to Hispaniola Hispaniolan trogon In Sierra de Bahoruco National Park, Dominican Republic Conservation status Least Concern (IUCN 3.1)[1] Scientific classification Domain: Eukaryota Kingdom: Animalia Phylum: Chordata Class: Aves Order: Trogoniformes Family: Trogonidae Genus: Priotelus Species: P. roseigaster Binomial name Priotelus roseigaster(Vieillot, 1817) Range in green Synonyms Temnotrogon roseigaster The Hispaniolan trogon (Priotelus roseigaster)...

 

Sri Paññavaro Mahathera

Sri Paññavaro MahatheraLahirHusodo (Ong Tik Tjong)22 Juli 1954 (umur 69)Blora, Jawa Tengah, IndonesiaKebangsaanIndonesiaNama lainBhante PaññavaroPekerjaanBikkhu, tokoh agama Buddha, Kepala Sangha Theravada Indonesia, Kepala Vihara Mendut MagelangKarya terkenalVihara Mendut Bhikku Paññavaro atau dikenal juga sebagai Sri Paññavaro Mahathera adalah Bhikku Indonesia. Ia merupakan tokoh penting dalam perkembangan sejarah Agama Buddha pada abad ke-19 di Indonesia. Ia merupakan pen...

A Thousand Splendid Suns

2007 novel by Khalid Hosseini A Thousand Splendid Suns First edition coverAuthorKhaled HosseiniCountryUnited StatesLanguageEnglishGenreNovelPublisherRiverhead Books (and Simon & Schuster audio CD)Publication dateMay 22, 2007Media typePrint (hardback & paperback) and audio CDPages384 pp (first edition, hardcover)ISBN978-1-59448-950-1 (first edition, hardcover)OCLC85783363Dewey Decimal813/.6 22LC ClassPS3608.O832 T56 2007 A Thousand Splendid Suns is a 2007 novel by Afghan-Amer...

 

Sierra Leonean dollar

Currency Sierra Leonean dollar The dollar was a currency issued in Sierra Leone between 1791 and 1805. It was subdivided into 100 cents and was issued by the Sierra Leone Company. The dollar was pegged to sterling at a rate of 1 dollar = 4 shillings 2 pence. Coins In 1791, coins were issued in denominations of 1, 10, 20, 50 cents, 1 penny and 1 dollar. The 1 cent and 1 penny were minted in bronze, the rest in silver. All the coins featured a lion on the obverse and two shaking hands, one whit...

 

العلاقات المجرية البلجيكية

العلاقات المجرية البلجيكية المجر بلجيكا   المجر   بلجيكا تعديل مصدري - تعديل   العلاقات المجرية البلجيكية هي العلاقات الثنائية التي تجمع بين المجر وبلجيكا.[1][2][3][4][5] مقارنة بين البلدين هذه مقارنة عامة ومرجعية للدولتين: وجه المقارنة المجر ب...

Pilkington Glass Championships 1990, одиночний розряд

Pilkington Glass Championships 1990, одиночний розряд International Women's Open 1990Переможець Мартіна НавратіловаФіналіст Гретхен МагерсРахунок фіналу 6-0, 6-2Дисципліни одиночний розряд парний розряд ← 1989 · International Women's Open · 1991 → Докладніше: International Women's Open 1990 В одиночному розряді...

 

Protorthoptera

Extinct order of insects ProtorthopteraTemporal range: 318–299 Ma PreꞒ Ꞓ O S D C P T J K Pg N Middle Carboniferous Hadentomum americanum Scientific classification Domain: Eukaryota Kingdom: Animalia Phylum: Arthropoda Class: Insecta Cohort: Polyneoptera Order: †ProtorthopteraHandlirsch, 1906 Families See text Synonyms Cacurgida Paraplecoptera Protoblattodea Protoblattoidea The Protorthoptera are an extinct order of Palaeozoic insects, and represent a wastebasket taxon and paraphy...

 

Bacterioplankton counting methods

Methods for the estimation of the abundance of bacterioplankton in a specific body of water Bacterioplankton counting is the estimation of the abundance of bacterioplankton in a specific body of water, which is useful information to marine microbiologists. Various counting methodologies have been developed over the years to determine the number present in the water being observed. Methods used for counting bacterioplankton include epifluorescence microscopy, flow cytometry, measures of produc...

Kika Toulouse

American soccer player (born 1989) Kika Toulouse Personal informationFull name Gabriella Monique Toulouse[1]Date of birth (1989-05-03) May 3, 1989 (age 34)Place of birth Arlington, Virginia, United StatesHeight 5 ft 6 in (1.68 m)Position(s) DefenderCollege careerYears Team Apps (Gls)2007–2010 Virginia Cavaliers Senior career*Years Team Apps (Gls)2012 Rågsveds IF[2] 21 (9)2013 Washington Spirit 13 (0)2014 Houston Dash 7 (0)International career2011–2012 ...

 

Ewaldsgade

Ewaldsgade with the listed building at No. 5 (red building) Ewaldsgade is a street in the Nørrebro district of Copenhagen, Denmark. It runs from Åboulevard in the south to Smedegade in the north. The buildings on the east side of the street overlook Peblinge Lake. The street is named for the poet Johannes Ewald. History Ewaldsgade—then referred to as Brogade—on a map detail from 1856 Ewaldsgade was created by Frederik Christopher Bülow, the inspector at Københavns Ladegård, w...

 

Have a Smile with Me

1964 studio album by Ray CharlesHave a Smile With MeStudio album by Ray CharlesReleasedJune 1964Recorded1964GenreR&B, soul, country soulLabelABC 495ProducerRay CharlesRay Charles chronology Sweet & Sour Tears(1964) Have a Smile With Me(1964) Live in Concert(1965) Alternative cover1997 Rhino CD re-issue with Ingredients in a Recipe for Soul Have a Smile With Me is a 1964 album by Ray Charles. In a reversal of the previous concept album Sweet & Sour Tears, this album is fill...

Чудаков, Евгений Алексеевич

В Википедии есть статьи о других людях с такой фамилией, см. Чудаков. Евгений Алексеевич Чудаков Дата рождения 20 августа (1 сентября) 1890 Место рождения Плавск, Тульская губерния, Российская империя Дата смерти 19 сентября 1953(1953-09-19)[1] (63 года) Место смерти Москва, РСФСР, СС...

 

Common Language Runtime

Virtual machine component of Microsoft's .NET framework This article has multiple issues. Please help improve it or discuss these issues on the talk page. (Learn how and when to remove these template messages) This article may rely excessively on sources too closely associated with the subject, potentially preventing the article from being verifiable and neutral. Please help improve it by replacing them with more appropriate citations to reliable, independent, third-party sources. (March 2019...

 

Strategi Solo vs Squad di Free Fire: Cara Menang Mudah!