Somatostatinski receptor 3

edit

Somatostatinski receptor 3
Identifikatori
Simboli	SSTR3;
Vanjski ID	OMIM: 182453 MGI: 98329 HomoloGene: 20285 IUPHAR: sst3 GeneCards: SSTR3 Gene
Ontologija gena Molekularna funkcija • aktivnost rodopsinu-sličnog receptora • receptorska aktivnost • aktivnost somatostatinskog receptora Celularna komponenta • integralno sa ćelijskom membranom • membrana Biološki proces • prenos signala • G-proteinska signalizacija, spregnuta sa ciklično nukleotidnim sekundarnim glasnikom • interćelijska signalizacija • negativna regulacija ćelijske proliferacije • indukcija apoptoze hormonima
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	6753	20607
Ensembl	ENSG00000183473	ENSMUSG00000044933
UniProt	P32745	Q0VB04
RefSeq (mRNA)	NM_001051	NM_009218
RefSeq (protein)	NP_001042	NP_033244
Lokacija (UCSC)	Chr 22: 35.93 - 35.94 Mb	Chr 15: 78.36 - 78.37 Mb
PubMed pretraga	[1]	[2]

Somatostatinski receptor tip 3 je protein koji je kod čoveka kodiran SSTR3 genom.^[1][2]

Somatostatin deluje na mnogim lokacijama i inhibira oslobađanje hormona i drugih sekretornih proteina. Biološki efekti somatostatina su posredovani familijom G protein-spregnutih receptora čije izražavanje je specifično za pojedina tkiva. SSTR3 u znatnoj meri izražen u mozgu i pankreasu. SSTR3 je funkcionalno spregnut sa adenilil ciklazom.^[2]

Vidi isto

• Somatostatinski receptor

Reference

1. Yamada Y, Stoffel M, Espinosa R 3rd, Xiang KS, Seino M, Seino S, Le Beau MM, Bell GI (Apr 1993). „Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms”. Genomics 15 (2): 449–52. DOI:10.1006/geno.1993.1088. PMID 8449518. 
2. „Entrez Gene: SSTR3 somatostatin receptor 3”. 

Literatura

• Yamada Y, Reisine T, Law SF, et al. (1993). „Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase.”. Mol. Endocrinol. 6 (12): 2136–42. DOI:10.1210/me.6.12.2136. PMID 1337145. 
• Yamada Y, Post SR, Wang K, et al. (1992). „Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.”. Proc. Natl. Acad. Sci. U.S.A. 89 (1): 251–5. DOI:10.1073/pnas.89.1.251. PMC 48214. PMID 1346068. 
• Corness JD, Demchyshyn LL, Seeman P, et al. (1993). „A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides.”. FEBS Lett. 321 (2-3): 279–84. DOI:10.1016/0014-5793(93)80124-D. PMID 8097479. 
• Law SF, Zaina S, Sweet R, et al. (1994). „Gi alpha 1 selectively couples somatostatin receptor subtype 3 to adenylyl cyclase: identification of the functional domains of this alpha subunit necessary for mediating the inhibition by somatostatin of cAMP formation.”. Mol. Pharmacol. 45 (4): 587–90. PMID 8183236. 
• Kaupmann K, Bruns C, Hoyer D, et al. (1993). „Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain.”. FEBS Lett. 331 (1-2): 53–9. DOI:10.1016/0014-5793(93)80296-7. PMID 8405411. 
• Sharma K, Patel YC, Srikant CB (1997). „Subtype-selective induction of wild-type p53 and apoptosis, but not cell cycle arrest, by human somatostatin receptor 3.”. Mol. Endocrinol. 10 (12): 1688–96. DOI:10.1210/me.10.12.1688. PMID 8961277. 
• Fukusumi S, Kitada C, Takekawa S, et al. (1997). „Identification and characterization of a novel human cortistatin-like peptide.”. Biochem. Biophys. Res. Commun. 232 (1): 157–63. DOI:10.1006/bbrc.1997.6252. PMID 9125122. 
• Ain KB, Taylor KD, Tofiq S, Venkataraman G (1997). „Somatostatin receptor subtype expression in human thyroid and thyroid carcinoma cell lines.”. J. Clin. Endocrinol. Metab. 82 (6): 1857–62. DOI:10.1210/jc.82.6.1857. PMID 9177396. 
• de Lecea L, Ruiz-Lozano P, Danielson PE, et al. (1997). „Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin.”. Genomics 42 (3): 499–506. DOI:10.1006/geno.1997.4763. PMID 9205124. 
• Roth A, Kreienkamp HJ, Meyerhof W, Richter D (1997). „Phosphorylation of four amino acid residues in the carboxyl terminus of the rat somatostatin receptor subtype 3 is crucial for its desensitization and internalization.”. J. Biol. Chem. 272 (38): 23769–74. DOI:10.1074/jbc.272.38.23769. PMID 9295322. 
• Dunham I, Shimizu N, Roe BA, et al. (1999). „The DNA sequence of human chromosome 22.”. Nature 402 (6761): 489–95. DOI:10.1038/990031. PMID 10591208. 
• Zatelli MC, Tagliati F, Taylor JE, et al. (2001). „Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt.”. J. Clin. Endocrinol. Metab. 86 (5): 2161–9. DOI:10.1210/jc.86.5.2161. PMID 11344221. 
• Talme T, Ivanoff J, Hägglund M, et al. (2001). „Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3.”. Clin. Exp. Immunol. 125 (1): 71–9. DOI:10.1046/j.1365-2249.2001.01577.x. PMC 1906108. PMID 11472428. 
• Pasquali D, Notaro A, Esposito D, et al. (2002). „[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]”. Minerva Endocrinol. 26 (3): 175–9. PMID 11753241. 
• Papotti M, Bongiovanni M, Volante M, et al. (2002). „Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis.”. Virchows Arch. 440 (5): 461–75. DOI:10.1007/s00428-002-0609-x. PMID 12021920. 
• Ferone D, Pivonello R, Van Hagen PM, et al. (2002). „Quantitative and functional expression of somatostatin receptor subtypes in human thymocytes.”. Am. J. Physiol. Endocrinol. Metab. 283 (5): E1056–66. DOI:10.1152/ajpendo.00205.2001. PMID 12376335. 
• Pasquali D, Notaro A, Bonavolonta' G, et al. (2002). „Somatostatin receptor genes are expressed in lymphocytes from retroorbital tissues in Graves' disease.”. J. Clin. Endocrinol. Metab. 87 (11): 5125–9. DOI:10.1210/jc.2002-020790. PMID 12414882. 
• Dizeyi N, Konrad L, Bjartell A, et al. (2002). „Localization and mRNA expression of somatostatin receptor subtypes in human prostatic tissue and prostate cancer cell lines.”. Urol. Oncol. 7 (3): 91–8. DOI:10.1016/S1078-1439(01)00173-9. PMID 12474541. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 

Vanjske veze

• „Somatostatin Receptors: sst₃”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03. 
• MeSH somatostatin+receptor+3