GPR3

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G protein-spregnuti receptor 3
Identifikatori
Simboli	GPR3; ACCA
Vanjski ID	OMIM: 600241 MGI: 101908 HomoloGene: 31303 IUPHAR: GPR3 GeneCards: GPR3 Gene
Ontologija gena Molekularna funkcija • aktivnost rodopsinu-sličnog receptora • receptorska aktivnost Celularna komponenta • integralno sa ćelijskom membranom • membrana Biološki proces • prenos signala • signalni put G-protein spregnutog receptora • G-protein signalizacija, put aktivacije adenilat ciklaze
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	2827	14748
Ensembl	ENSG00000181773	ENSMUSG00000049649
UniProt	P46089	Q3USD4
RefSeq (mRNA)	NM_005281	NM_008154
RefSeq (protein)	NP_005272	NP_032180
Lokacija (UCSC)	Chr 1: 27.59 - 27.59 Mb	Chr 4: 132.48 - 132.48 Mb
PubMed pretraga	[1]	[2]

GPR3, G-protein spregnuti receptor 3, je protein koji je kod čoveka kodiran GPR3 genom.^[1][2] Ovaj protein je transmembranski receptor koji učestvuje u prenosu signala.

Funkcija

GPR3 aktivira adenilat ciklazu u odsustvu liganda.^[3] GPR3 je izražen u jajnim ćelijama sisara gde održava mejozno zadržavanje i smatra se da je komunikacioni link između jajnih ćelija i okružujućeg somatskog tkiva.^[4] Bilo je predloženo da su sfingozin 1-fosfat (S1P) i sfingozilfosforilholin (SPC) GPR3 ligandi,^[5][6], međutim ti rezultati nisu potvrđeni testom β-arestin regrutovanja.^[7]

Literatura

1. Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, Tsui LC, Shi X, George SR, O'Dowd BF (Mar 1995). „Cloning of human genes encoding novel G protein-coupled receptors”. Genomics 23 (3): 609–18. DOI:10.1006/geno.1994.1549. PMID 7851889. 
2. „Entrez Gene: GPR3 G protein-coupled receptor 3”. 
3. Eggerickx D, Denef JF, Labbe O, Hayashi Y, Refetoff S, Vassart G, Parmentier M, Libert F (August 1995). „Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase”. Biochem. J. 309 (Pt 3): 837–43. PMC 1135708. PMID 7639700. 
4. Mehlmann LM, Saeki Y, Tanaka S, Brennan TJ, Evsikov AV, Pendola FL, Knowles BB, Eppig JJ, Jaffe LA (December 2004). „The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes”. Science (journal) 306 (5703): 1947–50. DOI:10.1126/science.1103974. PMID 15591206. 
5. Uhlenbrock K, Gassenhuber H, Kostenis E (November 2002). „Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors”. Cell. Signal. 14 (11): 941–53. DOI:10.1016/S0898-6568(02)00041-4. PMID 12220620. 
6. Hinckley M, Vaccari S, Horner K, Chen R, Conti M (November 2005). „The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP signaling and maintenance of meiotic arrest in rodent oocytes”. Dev. Biol. 287 (2): 249–61. DOI:10.1016/j.ydbio.2005.08.019. PMID 16229830. 
7. Yin H, Chu A, Li W, Wang B, Shelton F, Otero F, Nguyen DG, Caldwell JS, Chen YA (May 2009). „Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay”. J. Biol. Chem. 284 (18): 12328–38. DOI:10.1074/jbc.M806516200. PMC 2673301. PMID 19286662. 

Dodatna literatura

• Eggerickx D, Denef JF, Labbe O, et al. (1995). „Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase.”. Biochem. J. 309 (Pt 3): 837–43. PMC 1135708. PMID 7639700. 
• Iismaa TP, Kiefer J, Liu ML, et al. (1995). „Isolation and chromosomal localization of a novel human G-protein-coupled receptor (GPR3) expressed predominantly in the central nervous system.”. Genomics 24 (2): 391–4. DOI:10.1006/geno.1994.1635. PMID 7698767. 
• Heiber M, Docherty JM, Shah G, et al. (1995). „Isolation of three novel human genes encoding G protein-coupled receptors.”. DNA Cell Biol. 14 (1): 25–35. DOI:10.1089/dna.1995.14.25. PMID 7832990. 
• Song ZH, Modi W, Bonner TI (1996). „Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors.”. Genomics 28 (2): 347–9. DOI:10.1006/geno.1995.1154. PMID 8530049. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Uhlenbrock K, Huber J, Ardati A, et al. (2003). „Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells.”. Cell. Physiol. Biochem. 13 (2): 75–84. DOI:10.1159/000070251. PMID 12649592. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Gregory SG, Barlow KF, McLay KE, et al. (2006). „The DNA sequence and biological annotation of human chromosome 1.”. Nature 441 (7091): 315–21. DOI:10.1038/nature04727. PMID 16710414.