Eikozanoidni receptor

Eikozanoidni receptor je integralni membranski protein koji detektuje prisustvo eikozanoidnih signalnih molekula. Većina, mada ne svi, su G protein spregnuti receptori. Primer ne-GPCR receptora koji vezuje eikozanoide je PPAR-γ.^[1]

Ovo su poznati humani eikozanoidni GPCR receptori grupisani po tipu eikozanoidnog liganda koji vezuju:^[2][3]

Leukotrien

Leukotrieni:

• CysLT₁ (Cisteinil leukotrienski receptor 1) - CYSLTR1
• CysLT₂ (Cisteinil leukotrienski receptor 2) - CYSLTR2
• BLT₁ (Leukotrienski B₄ receptor) - LTB4R
• BLT₂ (Leukotrienski B₄ receptor 2) - LTB4R2

Lipoksin

Lipoksini:

• LXA4R (Formil peptidnom receptoru-sličan 1) - FPRL1

Oksoeikozanoid

Oksoeikozanoid:^[4]

• Oksoeikozanoidni (OXE) receptor 1 - OXER1

Prostanoid

Prostanoidi:

• PGD₂: DP-(PGD₂)
  • DP₁ (Prostaglandin D2 receptor) - PTGDR
  • DP₂ (GPR44) - GPR44
• PGE₂:
  • EP₁-(PGE₂) (PTGER1) - PTGER1
  • EP₂-(PGE₂) (PTGER2) - PTGER2
  • EP₃-(PGE₂) (PTGER3) - PTGER3
  • EP₄-(PGE₂) (PTGER4) - PTGER4
• PGF_2α: FP-(PGF_2α) (PTGFR) - PTGFR
• PGI₂ (prostaciklin): IP-(PGI₂) (PTGIR) - PTGIR
• TXA₂ (tromboksan): TP-(TXA₂) (TBXA2R) - TBXA2R

Reference

1. DuBois RN, Gupta R, Brockman J, Reddy BS, Krakow SL, Lazar MA (1998). „The nuclear eicosanoid receptor, PPAR-γ, is aberrantly expressed in colonic cancers”. Carcinogenesis 19 (1): 49–53. DOI:10.1093/carcin/19.1.49. PMID 9472692. 
2. Coleman RA, Smith WL, Narumiya S (1994). „International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes”. Pharmacol. Rev. 46 (2): 205–29. PMID 7938166. 
3. Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Nicosia S, Serhan CN, Shimizu T, Yokomizo T (2003). „International Union of Pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors”. Pharmacol. Rev. 55 (1): 195–227. DOI:10.1124/pr.55.1.8. PMID 12615958. 
4. Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Rovati GE, Serhan CN, Shimizu T, Yokomizo T (2004). „International Union of Pharmacology XLIV. Nomenclature for the oxoeicosanoid receptor”. Pharmacol. Rev. 56 (1): 149–57. DOI:10.1124/pr.56.1.4. PMID 15001665. 

Vanjske veze

• „Leukotriene Receptors”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03. 
• „Prostanoid Receptors”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2021-04-15. 
• MeSH Eicosanoid+receptors