Alfa-1B adrenergički receptor

Adrenergički alfa-1B receptor
Identifikatori
Simboli	ADRA1B; ADRA1; ALPHA1BAR
Vanjski ID	OMIM: 104220 MGI: 104774 HomoloGene: 55477 IUPHAR: α1B-adrenoceptor GeneCards: ADRA1B Gene
Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu-sličnog receptora • receptorska aktivnost • adrenoceptorska aktivnost • aktivnost alfa 1 adrenergičkog receptora
Celularna komponenta	• integralno sa membranom • membrana
Biološki proces	• remodelovanje krvnih sudova • respons na amfetamin • vazokonstrikcija arterija tokom baroreceptorskog responsa na sniženje krvnog pritiska • pozitivna regulacija brzine srčanih kontrakcija epinefrin-norepinefrina • povećanja snage srčanih kontrakcija epinefrinom-norepinefrinom • prenos signala • signalni put G-protein spregnutog receptora • G-proteinska signalizacija, spregnuta sa cAMP nukleotidnim sekundarnim glasnikom • kaskada proteinskih kinaza • interćelijska signalizacija • razvoj multićelijskog organizma • razvoj srca odraslih osoba • lokomotorno ponašanje • ćelijska proliferacija • vizuelno učenje • ćelijski rast • rast organa • glukozna homeostaza • respons na morfin • negativna regulacija glikogenskog kataboličkog procesa • pozitivna regulacija glikogenskog kataboličkog procesa • ponašanje u odgovoru na kokain
Pregled RNK izražavanja
	podaci
Ortolozi

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Alfa-1B adrenergički receptor (α_1B adrenoreceptor, ADRA1B), je alfa-1 adrenergički receptor, kodiran ADRA1B humanim genom.^[1]

Receptor

Postoje 3 tipa alfa-1 adrenergičkog receptora: alfa-1A, -1B i -1D. Svi oni prenose signal kroz Gq/11 familiju G-proteina. Različiti tipovi pokazuju različite oblike aktivacije. Oni aktiviraju mitogene response i regulišu rast i proliferaciju mnogih ćelija.

Gen

Ovaj gen kodira alfa-1B-adrenergički receptor, koji indukuje neoplastičnu transformaciju kad se transfektira u NIH 3T3 fibroblaste i druge ćelijske linije. Iz tog razloga je ovaj normalni ćelijski gen identifikovan kao protoonkogen. On se sastoji od 2 iRNK eksona i jednog velikog introna sa najmanje 20 kb.^[1]

Interakcije

Za alfa-1B adrenergički receptor je pokazano da interaguje sa AP2M1.^[2] Takođe se smatra da ima ulogu u dopaminergičkoj neurotransmisiji.^[3]^[4]

Povezano

Adrenergički receptor

Reference

↑ ^1,0 ^1,1 „Entrez Gene: ADRA1B adrenergic, alpha-1B-, receptor”. Entrez Gene: ADRA1B adrenergic, alpha-1B-, receptor.
↑ Diviani, Dario; Lattion Anne-Laure, Abuin Liliane, Staub Olivier, Cotecchia Susanna (May 2003). „The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and plays a role in receptor endocytosis”. J. Biol. Chem. (United States) 278 (21): 19331–40. DOI:10.1074/jbc.M302110200. ISSN 0021-9258. PMID 12644451.
↑ Drouin C, Darracq L, Trovero F, Blanc G, Glowinski J, Cotecchia S, Tassin JP (April 2002). „Alpha1b-adrenergic receptors control locomotor and rewarding effects of psychostimulants and opiates”. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 22 (7): 2873–84. PMID 11923452.
↑ Auclair A, Drouin C, Cotecchia S, Glowinski J, Tassin JP (December 2004). „5-HT2A and alpha1b-adrenergic receptors entirely mediate dopamine release, locomotor response and behavioural sensitization to opiates and psychostimulants”. The European Journal of Neuroscience 20 (11): 3073–84. DOI:10.1111/j.1460-9568.2004.03805.x. PMID 15579162.

Literatura

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