Receptor insulinu sličnog faktora rasta 1

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Receptor insulinu sličnog faktora rasta 1‎‎
Prva tri domena receptora insulinu sličnog faktora rasta 1‎‎. PDB prikaz baziran na 1igr.
Dostupne strukture
1IGR, 1JQH, 1K3A, 1M7N, 1P4O, 2OJ9, 2ZM3, 3D94, 3F5P, 3I81, 3LVP, 3LW0, 3NW5, 3NW6, 3NW7, 3O23, 3QQU
Identifikatori
Simboli	IGF1R; CD221; IGFIR; IGFR; JTK13
Vanjski ID	OMIM: 147370 MGI: 96433 HomoloGene: 30997 GeneCards: IGF1R Gene
EC broj	2.7.10.1
Ontologija gena Molekularna funkcija • aktivnost proteinske tirozinske kinaze • aktivnost receptora insulinu sličnog faktora rasta • vezivanje insulinskog receptora Celularna komponenta • integralno sa ćelijskom membranom • kaveola • membrana Biološki proces • imunski respons • prenos signala • aksonogeneza
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	3480	16001
Ensembl	ENSG00000140443	ENSMUSG00000005533
UniProt	P08069	Q60751
RefSeq (mRNA)	NM_000875.3	NM_010513.2
RefSeq (protein)	NP_000866.1	NP_034643.2
Lokacija (UCSC)	Chr 15: 99.19 - 99.51 Mb	Chr 7: 67.95 - 68.23 Mb
PubMed pretraga	[1]	[2]

Receptor insulinu sličnog faktora rasta 1 je protein koji je prisutan na površini ljudskih ćelija. On je transmembranski receptor koji se aktivira IGF-1 hormonom (insulinu sličan faktor rasta 1) i srodnim hormonom IGF-2. On pripada velikoj klasi tirozinsko kinaznih receptora . Ovaj receptor posreduje dejstvo IGF-1, koji je polipeptidni proteinski hormon sličan insulinu. IGF-1 utiče na razviće i nastavlja da vrši anaboličko dejstvo kod odraslih. On može da indukuje hipertroifju skeletalnih mišića i drugih ciljnih tkiva. Miševi bez IGF-1 receptora umiru u kasnijem periodu razvića, i manifestuju dramatičnu redukcu telesne mase, što potvrđuje jak uticaj ovog receptora. Miševi sa samo jednom funkcionalnom kopijom IGF1R su normalni, ali ispoljavaju ~15% umanjenje telesne mase.

Interakcije

Receptor insulinu sličnog faktora rasta 1 formira interakcije sa SOCS3,^[1] PTPN11,^[2][3] SOCS2,^[4] GRB10,^[5][6][7][8] PIK3R3,^[9] C-src tirosinska kinaza,^[10] EHD1,^[11] Cbl genom,^[12] RAS p21 proteinskim aktivatorom 1,^[3] IRS1,^[2][6][13] ARHGEF12,^[14] YWHAE,^[15] Mdm2,^[12] SHC1^[6][13][16] i NEDD4.^[5][12]

Regulacija

Postoji evidencija da je IGF1R negativno regulisan dejstvom mikroRNK miR-7.^[17]

References

1. Dey, B R; Furlanetto R W, Nissley P (November 2000). „Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor”. Biochem. Biophys. Res. Commun. (UNITED STATES) 278 (1): 38–43. DOI:10.1006/bbrc.2000.3762. ISSN 0006-291X. PMID 11071852. 
2. Mañes, S; Mira E, Gómez-Mouton C, Zhao Z J, Lacalle R A, Martínez-A C (April 1999). „Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility”. Mol. Cell. Biol. (UNITED STATES) 19 (4): 3125–35. ISSN 0270-7306. PMC 84106. PMID 10082579. 
3. Seely, B L; Reichart D R, Staubs P A, Jhun B H, Hsu D, Maegawa H, Milarski K L, Saltiel A R, Olefsky J M (August 1995). „Localization of the insulin-like growth factor I receptor binding sites for the SH2 domain proteins p85, Syp, and GTPase activating protein”. J. Biol. Chem. (UNITED STATES) 270 (32): 19151–7. DOI:10.1074/jbc.270.32.19151. ISSN 0021-9258. PMID 7642582. 
4. Dey, B R; Spence S L, Nissley P, Furlanetto R W (September 1998). „Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor”. J. Biol. Chem. (UNITED STATES) 273 (37): 24095–101. DOI:10.1074/jbc.273.37.24095. ISSN 0021-9258. PMID 9727029. 
5. Vecchione, Andrea; Marchese Adriano, Henry Pauline, Rotin Daniela, Morrione Andrea (May 2003). „The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor”. Mol. Cell. Biol. (United States) 23 (9): 3363–72. DOI:10.1128/MCB.23.9.3363-3372.2003. ISSN 0270-7306. PMC 153198. PMID 12697834. 
6. Dey, B R; Frick K, Lopaczynski W, Nissley S P, Furlanetto R W (June 1996). „Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10”. Mol. Endocrinol. (UNITED STATES) 10 (6): 631–41. DOI:10.1210/me.10.6.631. ISSN 0888-8809. PMID 8776723. 
7. He, W; Rose D W, Olefsky J M, Gustafson T A (March 1998). „Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains”. J. Biol. Chem. (UNITED STATES) 273 (12): 6860–7. DOI:10.1074/jbc.273.12.6860. ISSN 0021-9258. PMID 9506989. 
8. Morrione, A; Valentinis B, Li S, Ooi J Y, Margolis B, Baserga R (July 1996). „Grb10: A new substrate of the insulin-like growth factor I receptor”. Cancer Res. (UNITED STATES) 56 (14): 3165–7. ISSN 0008-5472. PMID 8764099. 
9. Mothe, I; Delahaye L, Filloux C, Pons S, White M F, Van Obberghen E (December 1997). „Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins”. Mol. Endocrinol. (UNITED STATES) 11 (13): 1911–23. DOI:10.1210/me.11.13.1911. ISSN 0888-8809. PMID 9415396. 
10. Arbet-Engels, C; Tartare-Deckert S, Eckhart W (February 1999). „C-terminal Src kinase associates with ligand-stimulated insulin-like growth factor-I receptor”. J. Biol. Chem. (UNITED STATES) 274 (9): 5422–8. DOI:10.1074/jbc.274.9.5422. ISSN 0021-9258. PMID 10026153. 
11. Rotem-Yehudar, R; Galperin E, Horowitz M (August 2001). „Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29”. J. Biol. Chem. (United States) 276 (35): 33054–60. DOI:10.1074/jbc.M009913200. ISSN 0021-9258. PMID 11423532. 
12. Sehat, Bita; Andersson Sandra, Girnita Leonard, Larsson Olle (July 2008). „Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis”. Cancer Res. (United States) 68 (14): 5669–77. DOI:10.1158/0008-5472.CAN-07-6364. PMID 18632619. 
13. Tartare-Deckert, S; Sawka-Verhelle D, Murdaca J, Van Obberghen E (October 1995). „Evidence for a differential interaction of SHC and the insulin receptor substrate-1 (IRS-1) with the insulin-like growth factor-I (IGF-I) receptor in the yeast two-hybrid system”. J. Biol. Chem. (UNITED STATES) 270 (40): 23456–60. DOI:10.1074/jbc.270.40.23456. ISSN 0021-9258. PMID 7559507. 
14. Taya, S; Inagaki N, Sengiku H, Makino H, Iwamatsu A, Urakawa I, Nagao K, Kataoka S, Kaibuchi K (November 2001). „Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF”. J. Cell Biol. (United States) 155 (5): 809–20. DOI:10.1083/jcb.200106139. ISSN 0021-9525. PMC 2150867. PMID 11724822. 
15. Craparo, A; Freund R, Gustafson T A (April 1997). „14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner”. J. Biol. Chem. (UNITED STATES) 272 (17): 11663–9. DOI:10.1074/jbc.272.17.11663. ISSN 0021-9258. PMID 9111084. 
16. Santen, R J; Song R X, Zhang Z, Kumar R, Jeng M-H, Masamura A, Lawrence J, Berstein L, Yue W (July 2005). „Long-term estradiol deprivation in breast cancer cells up-regulates growth factor signaling and enhances estrogen sensitivity”. Endocr. Relat. Cancer. 12 (England) Suppl 1 (Supplement_1): S61–73. DOI:10.1677/erc.1.01018. ISSN 1351-0088. PMID 16113100. 
17. Jiang, Lu; Liu, Xiqiang; Chen, Zujian; Jin, Yi; Heidbreder, Caroline E.; Kolokythas, Antonia; Wang, Anxun; Dai, Yang i dr.. (2010). „MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells”. Biochemical Journal 432 (1): 199–205. DOI:10.1042/BJ20100859. PMID 20819078. 

Literatura

• Benito M, Valverde AM, Lorenzo M (1996). „IGF-I: a mitogen also involved in differentiation processes in mammalian cells.”. Int. J. Biochem. Cell Biol. 28 (5): 499–510. DOI:10.1016/1357-2725(95)00168-9. PMID 8697095. 
• Butler AA, Yakar S, Gewolb IH, et al. (1999). „Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology.”. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 121 (1): 19–26. DOI:10.1016/S0305-0491(98)10106-2. PMID 9972281. 
• Zhang X, Yee D (2001). „Tyrosine kinase signalling in breast cancer: insulin-like growth factors and their receptors in breast cancer.”. Breast Cancer Res. 2 (3): 170–5. DOI:10.1186/bcr50. PMC 138771. PMID 11250706. 
• Gross JM, Yee D (2004). „The type-1 insulin-like growth factor receptor tyrosine kinase and breast cancer: biology and therapeutic relevance.”. Cancer Metastasis Rev. 22 (4): 327–36. DOI:10.1023/A:1023720928680. PMID 12884909. 
• Adams TE, McKern NM, Ward CW (2005). „Signalling by the type 1 insulin-like growth factor receptor: interplay with the epidermal growth factor receptor.”. Growth Factors 22 (2): 89–95. DOI:10.1080/08977190410001700998. PMID 15253384. 
• Surmacz E, Bartucci M (2005). „Role of estrogen receptor alpha in modulating IGF-I receptor signaling and function in breast cancer.”. J. Exp. Clin. Cancer Res. 23 (3): 385–94. PMID 15595626. 
• Wood AW, Duan C, Bern HA (2005). „Insulin-like growth factor signaling in fish.”. Int. Rev. Cytol. 243: 215–85. DOI:10.1016/S0074-7696(05)43004-1. PMID 15797461. 
• Sarfstein R, Maor S, Reizner N, et al. (2006). „Transcriptional regulation of the insulin-like growth factor-I receptor gene in breast cancer.”. Mol. Cell. Endocrinol. 252 (1-2): 241–6. DOI:10.1016/j.mce.2006.03.018. PMID 16647191. 

Povezano

• Insulinski receptor
• Linzitinib, inhibitor IGF-1 u kliničkim ispitivanje za tretman kancera

Spoljašnje veze

• MeSH IGF-1+Receptor