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Makrofagno stimulišući receptor 1 (c-met srodna tirozinska kinaza)
Dostupne strukture
	3PLS, 4FWW
Identifikatori
Simboli	MST1R; CD136; CDw136; PTK8; RON
Vanjski ID	OMIM: 600168 MGI: 99614 HomoloGene: 1835 GeneCards: MST1R Gene
EC broj	2.7.10.1
Ontologija gena
Molekulska funkcija	• aktivnost receptora faktora stimulacije makrofagne kolonije; • proteinsko vezivanje; • ATP vezivanje;
Ćelijska komponenta	• stres fiber; • integralna komponenta ćelijske membrane;
Biološki proces	• komponenta ćelijskog kretanja; • odbrambeni respons; • prenos signala;
Pregled RNK izražavanja
	podaci
Ortolozi

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Makrofagno stimulišući proteinski receptor je protein koji je kod ljudi kodiran MST1R genom.^[1]^[2] MST1R je takođe poznat kao RON (Recepteur d'Origine Nantais) kinaza, pri čemu ime potiče od francuskog grada u kome je otkriven. On je srodan sa c-MET receptorskom tirozinsko kinazom.^[1]^[3]

Interakcije

MST1R formira interakcije sa Grb2.^[4]^[5]

Reference

↑ ^1,0 ^1,1 Ronsin C, Muscatelli F, Mattei MG, Breathnach R (May 1993). „A novel putative receptor protein tyrosine kinase of the met family”. Oncogene 8 (5): 1195–202. PMID 8386824. Greška u referenci: Nevaljana oznaka <ref>; naziv "pmid8386824" je zadan više puta s različitim sadržajem
↑ „Entrez Gene: MST1R macrophage stimulating 1 receptor (c-met-related tyrosine kinase)”.
↑ Gaudino G, Follenzi A, Naldini L, Collesi C, Santoro M, Gallo KA, Godowski PJ, Comoglio PM (August 1994). „RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP”. EMBO J. 13 (15): 3524–32. PMC 395256. PMID 8062829.
↑ Li BQ, Wang MH, Kung HF, Ronsin C, Breathnach R, Leonard EJ, Kamata T (November 1995). „Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor”. Biochem. Biophys. Res. Commun. 216 (1): 110–8. DOI:10.1006/bbrc.1995.2598. PMID 7488076.
↑ Iwama A, Yamaguchi N, Suda T (November 1996). „STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family”. EMBO J. 15 (21): 5866–75. PMC 452340. PMID 8918464.

Literatura

Li BQ, Wang MH, Kung HF, et al. (1995). „Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor”. Biochem. Biophys. Res. Commun. 216 (1): 110–8. DOI:10.1006/bbrc.1995.2598. PMID 7488076.
Wang MH, Ronsin C, Gesnel MC, et al. (1994). „Identification of the ron gene product as the receptor for the human macrophage stimulating protein”. Science 266 (5182): 117–9. DOI:10.1126/science.7939629. PMID 7939629.
Gaudino G, Follenzi A, Naldini L, et al. (1994). „RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP”. EMBO J. 13 (15): 3524–32. PMC 395256. PMID 8062829.
Lee ST, Strunk KM, Spritz RA (1993). „A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes”. Oncogene 8 (12): 3403–10. PMID 8247543.
Collesi C, Santoro MM, Gaudino G, Comoglio PM (1996). „A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype”. Mol. Cell. Biol. 16 (10): 5518–26. PMC 231551. PMID 8816464.
Bonaldo MF, Lennon G, Soares MB (1997). „Normalization and subtraction: two approaches to facilitate gene discovery”. Genome Res. 6 (9): 791–806. DOI:10.1101/gr.6.9.791. PMID 8889548.
Iwama A, Yamaguchi N, Suda T (1997). „STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family”. EMBO J. 15 (21): 5866–75. PMC 452340. PMID 8918464.
Sakamoto O, Iwama A, Amitani R, et al. (1997). „Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility”. J. Clin. Invest. 99 (4): 701–9. DOI:10.1172/JCI119214. PMC 507853. PMID 9045873.
Follenzi A, Bakovic S, Gual P, et al. (2000). „Cross-talk between the proto-oncogenes Met and Ron”. Oncogene 19 (27): 3041–9. DOI:10.1038/sj.onc.1203620. PMID 10871856.
Chen YQ, Zhou YQ, Fisher JH, Wang MH (2002). „Targeted expression of the receptor tyrosine kinase RON in distal lung epithelial cells results in multiple tumor formation: oncogenic potential of RON in vivo”. Oncogene 21 (41): 6382–6. DOI:10.1038/sj.onc.1205783. PMID 12214279.
Chen YQ, Zhou YQ, Fu LH, et al. (2002). „Multiple pulmonary adenomas in the lung of transgenic mice overexpressing the RON receptor tyrosine kinase. Recepteur d'origine nantais”. Carcinogenesis 23 (11): 1811–9. DOI:10.1093/carcin/23.11.1811. PMID 12419829.
Zhou YQ, He C, Chen YQ, et al. (2003). „Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential”. Oncogene 22 (2): 186–97. DOI:10.1038/sj.onc.1206075. PMID 12527888.
Danilkovitch-Miagkova A, Duh FM, Kuzmin I, et al. (2003). „Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus”. Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4580–5. DOI:10.1073/pnas.0837136100. PMC 153598. PMID 12676986.
Rampino T, Gregorini M, Soccio G, et al. (2003). „The Ron proto-oncogene product is a phenotypic marker of renal oncocytoma”. Am. J. Surg. Pathol. 27 (6): 779–85. DOI:10.1097/00000478-200306000-00008. PMID 12766581.
Penengo L, Rubin C, Yarden Y, Gaudino G (2003). „c-Cbl is a critical modulator of the Ron tyrosine kinase receptor”. Oncogene 22 (24): 3669–79. DOI:10.1038/sj.onc.1206585. PMID 12802274.
Maggiora P, Lorenzato A, Fracchioli S, et al. (2003). „The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasiveness”. Exp. Cell Res. 288 (2): 382–9. DOI:10.1016/S0014-4827(03)00250-7. PMID 12915129.
Santoro MM, Gaudino G, Marchisio PC (2003). „The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration”. Dev. Cell 5 (2): 257–71. DOI:10.1016/S1534-5807(03)00201-6. PMID 12919677.
Angeloni D, Danilkovitch-Miagkova A, Miagkov A, et al. (2004). „The soluble sema domain of the RON receptor inhibits macrophage-stimulating protein-induced receptor activation”. J. Biol. Chem. 279 (5): 3726–32. DOI:10.1074/jbc.M309342200. PMID 14597639.
van den Akker E, van Dijk T, Parren-van Amelsvoort M, et al. (2004). „Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors”. Blood 103 (12): 4457–65. DOI:10.1182/blood-2003-08-2713. PMID 14982882.
Raeppel S, Gaudette G, et al. (2010). „Identification of a novel series of potent RON receptor tyrosine kinase inhibitors”. Bioorg. Med. Chem. Lett. 20 (9): 2745–9. DOI:10.1016/j.bmcl.2010.03.073.