ROS1 (gen)

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ROS proto-onkogen 1, receptorska tirozinska kinaza
Dostupne strukture
3ZBF
Identifikatori
Simboli	ROS1; MCF3; ROS; c-ros-1
Vanjski ID	OMIM: 165020 MGI: 97999 HomoloGene: 2207 GeneCards: ROS1 Gene
EC broj	2.7.10.1
Ontologija gena Molekulska funkcija • aktivnost proteinske tirozinske kinaze • aktivnost transmembranske receptorske proteinske tirozinske kinaze • proteinsko vezivanje Ćelijska komponenta • ćelijska membrana • membrana • integralna komponenta membrane Biološki proces • proteinska fosforilacija • signalni put transmembranske receptorske proteinske tirozinske kinaze • spermatogeneza
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	6098	19886
Ensembl	ENSG00000047936	ENSMUSG00000019893
UniProt	P08922	Q78DX7
Ref. Sekv. (iRNK)	NM_002944	NM_011282
Ref. Sekv. (protein)	NP_002935	NP_035412
Lokacija (UCSC)	Chr 6: 117.61 - 117.75 Mb	Chr 10: 52.05 - 52.2 Mb
PubMed pretraga	[1]	[2]

Proto-onkogenska tirozinska proteinska kinaza ROS je enzim koji je kod ljudi kodiran ROS1 genom.^[1][2]

Ovaj proto-onkogen, koji je visoko izražen u ćelijama tumora, pripada sevenless podfamiliji tirozinskih kinaza insulinskih receptorskih gena. Protein kodiran ovim genom je tip I integralnog membranskog proteina sa tirozinskom kinaznom aktivnošću. Ovaj protein može da deluje kao receptor faktora rasta ili diferencijacije.^[2]

Interakcije

ROS1 (gen) formira interakcije sa PTPN6.^[3]

Reference

1. Galland F, Stefanova M, Lafage M, Birnbaum D (July 1992). „Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23”. Cytogenet Cell Genet 60 (2): 114–6. DOI:10.1159/000133316. PMID 1611909. 
2. „Entrez Gene: ROS1 v-ros UR2 sarcoma virus oncogene homolog 1 (avian)”. 
3. Keilhack, H; Müller M, Böhmer S A, Frank C, Weidner K M, Birchmeier W, Ligensa T, Berndt A, Kosmehl H, Günther B, Müller T, Birchmeier C, Böhmer F D (January 2001). „Negative Regulation of Ros Receptor Tyrosine Kinase Signaling: An Epithelial Function of the Sh2 Domain Protein Tyrosine Phosphatase Shp-1”. J. Cell Biol. (United States) 152 (2): 325–34. DOI:10.1083/jcb.152.2.325. ISSN 0021-9525. PMC 2199605. PMID 11266449. 

Literatura

• Birchmeier C, O'Neill K, Riggs M, Wigler M (1990). „Characterization of ROS1 cDNA from a human glioblastoma cell line”. Proc. Natl. Acad. Sci. U.S.A. 87 (12): 4799–803. DOI:10.1073/pnas.87.12.4799. PMC 54205. PMID 2352949. 
• Sharma S, Birchmeier C, Nikawa J i dr.. (1990). „Characterization of the ros1-gene products expressed in human glioblastoma cell lines”. Oncogene Res. 5 (2): 91–100. PMID 2691958. 
• Birchmeier C, Sharma S, Wigler M (1988). „Expression and rearrangement of the ROS1 gene in human glioblastoma cells”. Proc. Natl. Acad. Sci. U.S.A. 84 (24): 9270–4. DOI:10.1073/pnas.84.24.9270. PMC 299735. PMID 2827175. 
• Matsushime H, Wang LH, Shibuya M (1987). „Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma virus encodes for a transmembrane receptorlike molecule”. Mol. Cell. Biol. 6 (8): 3000–4. PMC 367872. PMID 3023956. 
• Satoh H, Yoshida MC, Matsushime H i dr.. (1987). „Regional localization of the human c-ros-1 on 6q22 and flt on 13q12”. Jpn. J. Cancer Res. 78 (8): 772–5. PMID 3115921. 
• Birchmeier C, Birnbaum D, Waitches G i dr.. (1986). „Characterization of an activated human ros gene”. Mol. Cell. Biol. 6 (9): 3109–16. PMC 367045. PMID 3785223. 
• Sonnenberg-Riethmacher E, Walter B, Riethmacher D i dr.. (1996). „The c-ros tyrosine kinase receptor controls regionalization and differentiation of epithelial cells in the epididymis”. Genes Dev. 10 (10): 1184–93. DOI:10.1101/gad.10.10.1184. PMID 8675006. 
• Zeng L, Sachdev P, Yan L i dr.. (2001). „Vav3 Mediates Receptor Protein Tyrosine Kinase Signaling, Regulates GTPase Activity, Modulates Cell Morphology, and Induces Cell Transformation”. Mol. Cell. Biol. 20 (24): 9212–24. DOI:10.1128/MCB.20.24.9212-9224.2000. PMC 102179. PMID 11094073. 
• Keilhack H, Müller M, Böhmer SA i dr.. (2001). „Negative Regulation of Ros Receptor Tyrosine Kinase Signaling: An Epithelial Function of the Sh2 Domain Protein Tyrosine Phosphatase Shp-1”. J. Cell Biol. 152 (2): 325–34. DOI:10.1083/jcb.152.2.325. PMC 2199605. PMID 11266449. 
• Charest A, Kheifets V, Park J i dr.. (2003). „Oncogenic targeting of an activated tyrosine kinase to the Golgi apparatus in a glioblastoma”. Proc. Natl. Acad. Sci. U.S.A. 100 (3): 916–21. DOI:10.1073/pnas.242741799. PMC 298701. PMID 12538861. 
• Charest A, Lane K, McMahon K i dr.. (2003). „Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21)”. Genes Chromosomes Cancer 37 (1): 58–71. DOI:10.1002/gcc.10207. PMID 12661006. 
• Mungall AJ, Palmer SA, Sims SK i dr.. (2003). „The DNA sequence and analysis of human chromosome 6”. Nature 425 (6960): 805–11. DOI:10.1038/nature02055. PMID 14574404. 
• Légaré C, Sullivan R (2005). „Expression and localization of c-ros oncogene along the human excurrent duct”. Mol. Hum. Reprod. 10 (9): 697–703. DOI:10.1093/molehr/gah087. PMID 15235104. 
• Biskup C, Böhmer A, Pusch R i dr.. (2005). „Visualization of SHP-1-target interaction”. J. Cell. Sci. 117 (Pt 21): 5165–78. DOI:10.1242/jcs.01397. PMID 15456853. 
• Girish V, Sachdeva N, Minz RW i dr.. (2006). „Bcl2 and ROS1 expression in human meningiomas: an analysis with respect to histological subtype”. Indian journal of pathology & microbiology 48 (3): 325–30. PMID 16761743.