Receptor 4 fibroblastnog faktora rasta

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Receptor 4 fibroblastnog faktora rasta
Dostupne strukture
4TYG, 4TYI, 4TYE, 4TYJ[1]
Identifikatori
Simboli	FGFR4; CD334; JTK2; TKF
Vanjski ID	OMIM: 134935 MGI: 95525 HomoloGene: 20461 GeneCards: FGFR4 Gene
EC broj	2.7.10.1
Ontologija gena Molekulska funkcija • aktivnost proteinske tirozinske kinaze • ATP vezivanje • heparinsko vezivanje Ćelijska komponenta • ekstracelularni region • nukleus • nukleolus Biološki proces • indukcija organa • signalni put receptora epidermalnog faktora rasta • pozitivna regulacija ćelijske proliferacije
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	2264	14186
Ensembl	ENSG00000160867	ENSMUSG00000005320
UniProt	P22455	Q03142
Ref. Sekv. (iRNK)	NM_001291980	NM_008011
Ref. Sekv. (protein)	NP_001278909	NP_032037
Lokacija (UCSC)	Chr 5: 176.51 - 176.53 Mb	Chr 13: 55.15 - 55.17 Mb
PubMed pretraga	[1]	[2]

Receptor 4 fibroblastnog faktora rasta je protein koji je kod ljudi kodiran FGFR4 genom. FGFR4 se takođe označava sa CD334 (klaster diferencijacije 334).

Funkcija

Protein kodiran ovim genom je član familije receptora fibroblastnih faktora rasta (FGFR) među kojima je aminokiselinska sekvenca visoko konzervirana tokom evolucije. Članovi FGFR familije se međusobno razlikuju po nihovom afinitetu za ligande i tkivnoj distribuciji. Reprezentativni protein pune dužine se sastoji od ekstracelularnog regiona, sastavljenog od tri imunoglobulinu slična domena, jednog hidrofobnog jednoprolaznog membranskog segmenta i citoplazmatičnog tirozinskog kinaznog domena. Ekstracelularna porcija proteina interaguje sa fibroblastnim faktorima rasta, čime se pokreće signalna kaslada koja utiče na mitogenezu i diferencijaciju. Ovaj član familije se vezuje za kisele i bazne fibroblastne faktore rasta. Genomska organizacija ovog gena, u poređenju sa članovima 1-3, obuhvata 18 eksona umesto 19 ili 20. Mada su alternativno splajsovane varijante poznate, nema dokaza da se C-terminalna polovina IgIII domena ovog proteina razlikuje među izoformama. Ovaj protein preferentno vezuje kisele fibroblastne faktore rasta i mada njegova specifična funkcija nije poznata, on je prekomerno izražen u uzorcima ginekoloških tumora, što sugeriše da učestvuje u tumogenezi u dojkama i jajnicima.^[2] }}

Interakcije

Receptor 4 fibroblastnog faktora rasta formira interakcije sa FGF1.^[3][4]

Povezano

• Klaster diferencijacije

Reference

1. Lesca, E., Lammens, A., Huber, R., Augustin, M.. „Structural analysis of the human Fibroblast Growth Factor Receptor 4 kinase”. J. Mol. Biol.. DOI:10.1016/j.jmb.2014.09.004. 
2. „Entrez Gene: FGFR4 fibroblast growth factor receptor 4”. Entrez Gene: FGFR4 fibroblast growth factor receptor 4. 
3. Loo, B B; Darwish K K; Vainikka S S; Saarikettu J J; Vihko P P; Hermonen J J; Goldman A A; Alitalo K K i dr.. (May 2000). „Production and characterization of the extracellular domain of recombinant human fibroblast growth factor receptor 4”. Int. J. Biochem. Cell Biol. (ENGLAND) 32 (5): 489–97. DOI:10.1016/S1357-2725(99)00145-4. ISSN 1357-2725. PMID 10736564. 
4. Kan, M; Wu X; Wang F; McKeehan W L (May 1999). „Specificity for fibroblast growth factors determined by heparan sulfate in a binary complex with the receptor kinase”. J. Biol. Chem. (UNITED STATES) 274 (22): 15947–52. DOI:10.1074/jbc.274.22.15947. ISSN 0021-9258. PMID 10336501. 

Literatura

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Vanjske veze

• MeSH FGFR4+protein,+human