Src (gen)

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V-src sarkoma viralni onkogeni homolog (avijarni)
PDB prikaz baziran na 1a07.
Dostupne strukture
1a07, 1a08, 1a09, 1a1a, 1a1b, 1a1c, 1a1e, 1bkl, 1bkm, 1f1w, 1f2f, 1fmk, 1hcs, 1hct, 1is0, 1kc2, 1ksw, 1nlo, 1nlp, 1nzl, 1nzv, 1o41, 1o42, 1o43, 1o44, 1o45, 1o46, 1o47, 1o48, 1o49, 1o4a, 1o4b, 1o4c, 1o4d, 1o4e, 1o4f, 1o4g, 1o4h, 1o4i, 1o4j, 1o4k, 1o4l, 1o4m, 1o4n, 1o4o, 1o4p, 1o4q, 1o4r, 1p13, 1prl, 1prm, 1qwe, 1qwf, 1rlp, 1rlq, 1sha, 1shb, 1shd, 1skj, 1spr, 1sps, 1srl, 1srm, 1y57, 1yi6, 1yoj, 1yol, 1yom, 2bdf, 2bdj, 2h8h, 2hwo, 2hwp, 2oiq, 2ptk, 2src
Identifikatori
Simboli	SRC; ASV; SRC1; c-SRC; p60-Src
Vanjski ID	OMIM: 190090 MGI: 98397 HomoloGene: 21120 GeneCards: SRC Gene
Ontologija gena Molekularna funkcija • nukleotidno vezivanje • aktivnost proteinske-tirozinske kinaze • aktivnost SH3/SH2 adaptera • proteinsko vezivanje • ATP vezivanje • aktivnost transferaze • vezivanje SH2 domena Celularna komponenta • membrana • integralno sa membranom Biološki proces • proteinska aminokiselinka fosforilacija • formiranje signalnog kompleksa • kaskada proteinskih kinaza
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	6714	20779
Ensembl	ENSG00000197122	ENSMUSG00000027646
UniProt	P12931	Q2M4I4
RefSeq (mRNA)	NM_005417	NM_001025395
RefSeq (protein)	NP_005408	NP_001020566
Lokacija (UCSC)	Chr 20: 35.41 - 35.47 Mb	Chr 2: 157.12 - 157.16 Mb
PubMed pretraga	[1]	[2]

Src je proto-onkogenska tirozinska kinaza. Src su otkrili Mihael Bišop i Harold Varmus. Za ovo otkriće im je dodeljena Nobelova nagrada za fiziologiju ili medicinu 1989. godine.^[1] Ova kinaza pripada familiji nespecifičnih proteinskih tirozinskih kinaza koja se naziva Src familijom kinaza. Otkriće Src porodice proteina je imalo presudnu ulogu u modernom shvatanju rak kao bolesti u kojoj se inače zdrava ćelijska signalizacija pokvari.

Ovaj gen je sličan sa v-src genom Rous sarkoma virusa. Ovaj proto-onkogen može da igra ulogu u regulisanju embrionalnog razvoja i rasta ćelija. Proteinska kinaza koju ovaj gen kodira se može inhibirati fosforilacijom c-SRC kinazom. Mutacije ovog gena mogu da učestvuju u malignom razvoju raka debelog creva. Dve transkriptne varijante koje kodiraju isti protein su nađene za ovaj gen.^[2]

Interactions

Za Src gen je bilo pokazano da interaguje sa GRIN2A,^[3][4] C-Raf,^[5] CD44,^[6] Jedreni translokator arilnog ugljovodoničnog receptora,^[7] Aryl hydrocarbon receptor,^[7] PDE6G,^[8] STAT1,^[9][10] EPH receptor B2,^[11][12] Androgenski receptor,^[13][14][15] Proteinska kinaza Mζ,^[16] STAT3,^[17] Grb2,^[8][18] Beta-3 adrenergički receptor,^[19] Kinaza beta adrenergičkog receptora,^[8] Receptor epidermalnog faktora rasta,^[9][20][21] PTK2,^{[22][23][24][25][26][27]} DAB2,^[28] EPS8,^[29] Distroglikan,^[30] Estrogenski receptor alfa,^{[13][31][32][33]} Estrogenski receptor beta,^[13][33] HNF1A,^[34] KHDRBS1,^{[35][36][37][38][39]} DDEF1,^[40] MUC1,^[41][42] PTK2B,^[20][43][44] BCAR1,^{[45][22][46][47][48][24]} SHB,^[49] PLD2,^[50] Faktor responsa seruma,^[51] NCOA6,^{[52][53][54][55]} Receptor retinoiske kiseline alfa,^[32][56] Protein Viskot-Oldrić sindroma,^[57][58] RICS,^[59] RAS p21 proteinski activator 1,^[60][61] MT-ND2^[62] i GNB2L1.^[63]

Reference

1. Nobel Prize in Physiology or Medicine for 1989 jointly to J. Michael Bishop and Harold E. Varmus for their discovery of "the cellular origin of retroviral oncogenes". Press Release.
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Povezano

• C-src tirozinska kinaza
• Dasatinib
• SU6656