EPHB6

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EPH receptor B6
Identifikatori
Simboli	EPHB6; HEP
Vanjski ID	OMIM: 602757 MGI: 1096338 HomoloGene: 20940 GeneCards: EPHB6 Gene
EC broj	2.7.10.1
Ontologija gena Molekulska funkcija • receptorska aktivnost • efrinska receptorska aktivnost • ATP vezivanje Ćelijska komponenta • extracelularni region • integralna komponenta ćelijske membrane Biološki proces • proteinska fosforilacija • paratiroid hormonska sekrecija • signalni put efrinskog receptora
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	2051	13848
Ensembl	ENSG00000106123	ENSMUSG00000029869
UniProt	O15197	O08644
Ref. Sekv. (iRNK)	NM_001280794	NM_001146351
Ref. Sekv. (protein)	NP_001267723	NP_001139823
Lokacija (UCSC)	Chr 7: 142.55 - 142.57 Mb	Chr 6: 41.61 - 41.62 Mb
PubMed pretraga	[1]	[2]

Receptor 6 efrinskog tipa B je protein koji je kod ljudi kodiran EPHB6 genom.^[1]

Efrinski receptori i njihovi ligandi, efrini, posreduju brojne procese razvića, posebno u nervnom sistemu. Na bazi njihovih struktura i sekvenci, efrini se dele u efrinsku klasu A (EFNA), koja se fiksira na membrani putem glikozilfosfatidilinozitolne veze, i efrinsku klasu B (EFNB), koji su transmembranski proteini. Eph familija receptora se deli u dve groupe na osnovu sličnosti njihovih sekvenci ekstracelularnog domena i njihovog afiniteta vezivanja liganda efrina A i efrina B. Efrinski receptori su najveća podgrupa receptora tirozinske kinazne (RTK) familije. Protein kodiran ovim genom je receptor za efrinske-B članove familije.^[1]

Reference

1. „Entrez Gene: EPHB6 EPH receptor B6”. 

Literatura

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• Zhou R (1998). „The Eph family receptors and ligands”. Pharmacol. Ther. 77 (3): 151–81. DOI:10.1016/S0163-7258(97)00112-5. PMID 9576626. 
• Holder N, Klein R (1999). „Eph receptors and ephrins: effectors of morphogenesis”. Development 126 (10): 2033–44. PMID 10207129. 
• Wilkinson DG (2000). „Eph receptors and ephrins: regulators of guidance and assembly”. Int. Rev. Cytol.. International Review of Cytology 196: 177–244. DOI:10.1016/S0074-7696(00)96005-4. ISBN 978-0-12-364600-2. PMID 10730216. 
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• Wilkinson DG (2001). „Multiple roles of EPH receptors and ephrins in neural development”. Nat. Rev. Neurosci. 2 (3): 155–64. DOI:10.1038/35058515. PMID 11256076. 
• Bonaldo MF, Lennon G, Soares MB (1997). „Normalization and subtraction: two approaches to facilitate gene discovery”. Genome Res. 6 (9): 791–806. DOI:10.1101/gr.6.9.791. PMID 8889548. 
• Matsuoka H, Iwata N, Ito M, et al. (1997). „Expression of a kinase-defective Eph-like receptor in the normal human brain”. Biochem. Biophys. Res. Commun. 235 (3): 487–92. DOI:10.1006/bbrc.1997.6812. PMID 9207182. 
• Ephnomenclaturecommittee, (1997). „Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee”. Cell 90 (3): 403–4. DOI:10.1016/S0092-8674(00)80500-0. PMID 9267020. 
• Hock B, Böhme B, Karn T, et al. (1998). „PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor”. Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9779–84. DOI:10.1073/pnas.95.17.9779. PMC 21413. PMID 9707552. 
• Munthe E, Rian E, Holien T, et al. (2000). „Ephrin-B2 is a candidate ligand for the Eph receptor, EphB6”. FEBS Lett. 466 (1): 169–74. DOI:10.1016/S0014-5793(99)01793-7. PMID 10648835. 
• Shimoyama M, Matsuoka H, Tamekane A, et al. (2000). „T-cell-specific expression of kinase-defective Eph-family receptor protein, EphB6 in normal as well as transformed hematopoietic cells”. Growth Factors 18 (1): 63–78. DOI:10.3109/08977190009003234. PMID 10831073. 
• Tang XX, Zhao H, Robinson ME, et al. (2000). „Implications of EPHB6, EFNB2, and EFNB3 expressions in human neuroblastoma”. Proc. Natl. Acad. Sci. U.S.A. 97 (20): 10936–41. DOI:10.1073/pnas.190123297. PMC 27127. PMID 10984508. 
• Luo H, Wan X, Wu Y, Wu J (2001). „Cross-linking of EphB6 resulting in signal transduction and apoptosis in Jurkat cells”. J. Immunol. 167 (3): 1362–70. DOI:10.4049/jimmunol.167.3.1362. PMID 11466354.