Leukocitna receptorska tirozinska kinaza

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Leukocitna receptorska tirozinska kinaza‎
Identifikatori
Simboli	LTK; TYK1
Vanjski ID	OMIM: 151520 MGI: 96840 HomoloGene: 130502 GeneCards: LTK Gene
EC broj	2.7.10.1
Ontologija gena Molekulska funkcija • aktivnost proteinske kinaze • aktivnost proteinske tirozinske kinaze • ATP vezivanje Ćelijska komponenta • ćelijska membrana • integralna komponenta ćelijske membrane • membrana Biološki proces • proteinska fosforilacija • prenos signala • ćelijska proliferacija
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	4058	17005
Ensembl	ENSG00000062524	ENSMUSG00000027297
UniProt	P29376	P08923
Ref. Sekv. (iRNK)	NM_001135685	NM_008523
Ref. Sekv. (protein)	NP_001129157	NP_032549
Lokacija (UCSC)	Chr 15: 41.8 - 41.81 Mb	Chr 2: 119.75 - 119.76 Mb
PubMed pretraga	[1]	[2]

Leukocitna receptorska tirozinska kinaza je enzim koji je kod ljudi kodiran LTK genom.^[1][2]

Protein kodiran ovim genom je član ALK/LTK receptorske familije receptorskih tirozinskih kinaza (RTK). Njegov ligand nije poznat.^[3] Ovaj receptor je srodna sa insulinskom receptorskom familijom. Specifična tirozinska fosforilacija proteina je ključna za kontrolu raznovrsnih signalnih puteva, koji dovode do ćelijskog razvića i diferencijacije. Dve alternativno splajsovane transkriptne varijante koje kodiraju različite izoforme su poznate.^[2]

Interakcije

LTK formira interakcije sa IRS-1, Shc, i PIK3R1.^[4][5]

Reference

1. Maru Y, Hirai H, Takaku F (May 1990). „Human ltk: gene structure and preferential expression in human leukemic cells”. Oncogene Res 5 (3): 199–204. PMID 2320375. 
2. „Entrez Gene: LTK leukocyte tyrosine kinase”. 
3. Lopes, Susana (2008). „Leukocyte tyrosine kinase functions in pigment cell development”. PLoS genetics. 
4. Kozutsumi, H; Toyoshima H; Hagiwara K; Yazaki Y; Hirai H (October 1994). „Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo”. Oncogene (ENGLAND) 9 (10): 2991–8. ISSN 0950-9232. PMID 8084603. 
5. Ueno, H; Honda H; Nakamoto T; Yamagata T; Sasaki K; Miyagawa K; Mitani K; Yazaki Y i dr.. (June 1997). „The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase”. Oncogene (ENGLAND) 14 (25): 3067–72. DOI:10.1038/sj.onc.1201153. ISSN 0950-9232. PMID 9223670. 

Literatura

• Krolewski JJ, Dalla-Favera R (1991). „The ltk gene encodes a novel receptor-type protein tyrosine kinase.”. Embo J. 10 (10): 2911–9. PMC 453005. PMID 1655406. 
• Krolewski JJ, Lee R, Eddy R, et al. (1990). „Identification and chromosomal mapping of new human tyrosine kinase genes.”. Oncogene 5 (3): 277–82. PMID 2156206. 
• Ben-Neriah Y, Bauskin AR (1988). „Leukocytes express a novel gene encoding a putative transmembrane protein-kinase devoid of an extracellular domain.”. Nature 333 (6174): 672–6. DOI:10.1038/333672a0. PMID 2836739. 
• Toyoshima H, Kozutsumi H, Maru Y, et al. (1993). „Differently spliced cDNAs of human leukocyte tyrosine kinase receptor tyrosine kinase predict receptor proteins with and without a tyrosine kinase domain and a soluble receptor protein.”. Proc. Natl. Acad. Sci. U.S.A. 90 (12): 5404–8. DOI:10.1073/pnas.90.12.5404. PMC 46728. PMID 7685902. 
• Richard I, Broux O, Chiannilkulchai N, et al. (1995). „Regional localization of human chromosome 15 loci.”. Genomics 23 (3): 619–27. DOI:10.1006/geno.1994.1550. PMID 7851890. 
• Kozutsumi H, Toyoshima H, Hagiwara K, et al. (1994). „Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo.”. Oncogene 9 (10): 2991–8. PMID 8084603. 
• Kozutsumi H, Toyoshima H, Hagiwara K, et al. (1993). „Identification of the human ltk gene product in placenta and hematopoietic cell lines.”. Biochem. Biophys. Res. Commun. 190 (2): 674–9. DOI:10.1006/bbrc.1993.1101. PMID 8427607. 
• Ueno H, Sasaki K, Kozutsumi H, et al. (1996). „Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase.”. J. Biol. Chem. 271 (44): 27707–14. DOI:10.1074/jbc.271.44.27707. PMID 8910363. 
• Snijders AJ, Ho SC, Haase VH, et al. (1997). „A lymphocyte-specific Ltk tyrosine kinase isoform is retained in the endoplasmic reticulum in association with calnexin.”. J. Biol. Chem. 272 (2): 1297–301. DOI:10.1074/jbc.272.2.1297. PMID 8995435. 
• Ueno H, Honda H, Nakamoto T, et al. (1997). „The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase.”. Oncogene 14 (25): 3067–72. DOI:10.1038/sj.onc.1201153. PMID 9223670. 
• Espanel X, Huguenin-Reggiani M, Van Huijsduijnen RH (2003). „The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities.”. Protein Sci. 11 (10): 2326–34. DOI:10.1110/ps.0213402. PMC 2373693. PMID 12237455. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Li N, Nakamura K, Jiang Y, et al. (2004). „Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus.”. Hum. Mol. Genet. 13 (2): 171–9. DOI:10.1093/hmg/ddh020. PMID 14695357.