TYRO3

edit

TYRO3 proteinska tirozinska kinaza
PDB prikaz baziran na 1rhf.
Dostupne strukture
1RHF
Identifikatori
Simboli	TYRO3; BYK; Dtk; RSE; Sky; Tif
Vanjski ID	OMIM: 600341 MGI: 104294 HomoloGene: 4585 GeneCards: TYRO3 Gene
EC broj	2.7.10.1
Ontologija gena Molekulska funkcija • aktivnost proteinske tirozinske kinaze • aktivnost transmembranske receptorske proteinske tirozinske kinaze • proteinsko vezivanje • ATP vezivanje Ćelijska komponenta • nukleus • omotač jedra • membrana endoplazmatskog retikuluma • integralna komponenta ćelijske membrane Biološki proces • diferencijacija prirodnih ćelija ubica • ćelijska adhezija • prenos signala
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	7301	22174
Ensembl	ENSG00000092445	ENSMUSG00000027298
UniProt	Q06418	P55144
Ref. Sekv. (iRNK)	NM_006293	NM_001290800
Ref. Sekv. (protein)	NP_006284	NP_001277729
Lokacija (UCSC)	Chr 15: 41.85 - 41.87 Mb	Chr 2: 119.8 - 119.82 Mb
PubMed pretraga	[1]	[2]

Tirozinski proteinsko kinazni receptor TYRO3 je enzim koji je kod ljudi kodiran TYRO3 genom.^[1][2]

Interakcije

TYRO3 formira interakcije sa PIK3R1^[3] i GAS6.^[4][5]

Reference

1. Richard I, Broux O, Chiannilkulchai N, Fougerousse F, Allamand V, Bourg N, Brenguier L, Devaud C i dr.. (March 1995). „Regional localization of human chromosome 15 loci”. Genomics 23 (3): 619–27. DOI:10.1006/geno.1994.1550. PMID 7851890. 
2. „Entrez Gene: TYRO3 TYRO3 protein tyrosine kinase”. 
3. Lan, Z; Wu H; Li W; Wu S; Lu L; Xu M; Dai W (January 2000). „Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway”. Blood (UNITED STATES) 95 (2): 633–8. ISSN 0006-4971. PMID 10627473. 
4. Mark, M R; Chen J; Hammonds R G; Sadick M; Godowsk P J (April 1996). „Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl”. J. Biol. Chem. (UNITED STATES) 271 (16): 9785–9. DOI:10.1074/jbc.271.16.9785. ISSN 0021-9258. PMID 8621659. 
5. Nagata, K; Ohashi K; Nakano T; Arita H; Zong C; Hanafusa H; Mizuno K (November 1996). „Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases”. J. Biol. Chem. (UNITED STATES) 271 (47): 30022–7. DOI:10.1074/jbc.271.47.30022. ISSN 0021-9258. PMID 8939948. 

Literatura

• Mark MR, Scadden DT, Wang Z i dr.. (1994). „rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain”. J. Biol. Chem. 269 (14): 10720–8. PMID 7511603. 
• Toshima J, Ohashi K, Iwashita S, Mizuno K (1995). „Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase”. Biochem. Biophys. Res. Commun. 209 (2): 656–63. DOI:10.1006/bbrc.1995.1549. PMID 7537495. 
• Crosier KE, Hall LR, Lewis PM i dr.. (1995). „Isolation and characterization of the human DTK receptor tyrosine kinase”. Growth Factors 11 (2): 137–44. DOI:10.3109/08977199409001055. PMID 7857658. 
• Ohashi K, Mizuno K, Kuma K i dr.. (1994). „Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain”. Oncogene 9 (3): 699–705. PMID 8108112. 
• Dai W, Pan H, Hassanain H i dr.. (1994). „Molecular cloning of a novel receptor tyrosine kinase, tif, highly expressed in human ovary and testis”. Oncogene 9 (3): 975–9. PMID 8108143. 
• Polvi A, Armstrong E, Lai C i dr.. (1994). „The human TYRO3 gene and pseudogene are located in chromosome 15q14-q25”. Gene 134 (2): 289–93. DOI:10.1016/0378-1119(93)90109-G. PMID 8262388. 
• Mark MR, Chen J, Hammonds RG i dr.. (1996). „Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl”. J. Biol. Chem. 271 (16): 9785–9. DOI:10.1074/jbc.271.16.9785. PMID 8621659. 
• Crosier PS, Freeman SA, Orlic D i dr.. (1996). „The Dtk receptor tyrosine kinase, which binds protein S, is expressed during hematopoiesis”. Exp. Hematol. 24 (2): 318–23. PMID 8641360. 
• Nagata K, Ohashi K, Nakano T i dr.. (1997). „Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases”. J. Biol. Chem. 271 (47): 30022–7. DOI:10.1074/jbc.271.47.30022. PMID 8939948. 
• Kajii Y, Ninomiya D, Kato M i dr.. (1997). „A tyrosine kinase-like molecule is localized in the nuclear membrane of neurons: hippocampal behavior under stress”. Biol. Cell 88 (1–2): 45–54. DOI:10.1016/S0248-4900(97)86830-X. PMID 9175267. 
• Lan Z, Wu H, Li W i dr.. (2000). „Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway”. Blood 95 (2): 633–8. PMID 10627473. 
• Strausberg RL, Feingold EA, Grouse LH i dr.. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Yin JL, Hambly BD, Bao SS i dr.. (2004). „Expression of growth arrest-specific gene 6 and its receptors in dysfunctional human renal allografts”. Transpl. Int. 16 (9): 681–8. DOI:10.1007/s00147-003-0593-3. PMID 12768229. 
• Heiring C, Dahlbäck B, Muller YA (2004). „Ligand recognition and homophilic interactions in Tyro3: structural insights into the Axl/Tyro3 receptor tyrosine kinase family”. J. Biol. Chem. 279 (8): 6952–8. DOI:10.1074/jbc.M311750200. PMID 14623883. 
• Ota T, Suzuki Y, Nishikawa T i dr.. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039. 
• Gerhard DS, Wagner L, Feingold EA i dr.. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Gould WR, Baxi SM, Schroeder R i dr.. (2005). „Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses”. J. Thromb. Haemost. 3 (4): 733–41. DOI:10.1111/j.1538-7836.2005.01186.x. PMID 15733062. 
• Hafizi S, Gustafsson A, Stenhoff J, Dahlbäck B (2005). „The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases”. Int. J. Biochem. Cell Biol. 37 (11): 2344–56. DOI:10.1016/j.biocel.2005.05.006. PMID 15964779. 
• Shimojima M, Takada A, Ebihara H i dr.. (2006). „Tyro3 Family-Mediated Cell Entry of Ebola and Marburg Viruses”. J. Virol. 80 (20): 10109–16. DOI:10.1128/JVI.01157-06. PMC 1617303. PMID 17005688.