EPH receptor B4

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EPH receptor B4
PDB prikaz baziran na 2bba.
Dostupne strukture
2BBA, 2E7H, 2HLE, 2QKQ, 2VWU, 2VWV, 2VWW, 2VWX, 2VWY, 2VWZ, 2VX0, 2VX1, 2X9F, 2XVD, 2YN8, 3ZEW, 4AW5, 4BB4
Identifikatori
Simboli	EPHB4; HTK; MYK1; TYRO11
Vanjski ID	OMIM: 600011 MGI: 104757 HomoloGene: 20939 GeneCards: EPHB4 Gene
EC broj	2.7.10.1
Ontologija gena Molekulska funkcija • aktivnost transmembranske receptorske proteinske tirozinske kinaze • aktivnost efrinskog receptora • proteinsko vezivanje Ćelijska komponenta • integralna komponenta ćelijske membrane • extracelularni vesikularni eksozom Biološki proces • angiogeneza • srčana morfogeneza • ćelijska adhezija
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	2050	13846
Ensembl	ENSG00000196411	ENSMUSG00000029710
UniProt	P54760	P54761
Ref. Sekv. (iRNK)	NM_004444	NM_001159571
Ref. Sekv. (protein)	NP_004435	NP_001153043
Lokacija (UCSC)	Chr 7: 100.4 - 100.43 Mb	Chr 5: 137.35 - 137.38 Mb
PubMed pretraga	[1]	[2]

Receptor 4 efrinskog tipa B je protein koji je kod ljudi kodiran EPHB4 genom.^[1][2]

Efrinski receptori i njihovi ligandi, efrini, posreduju brojne procese razvića, posebno u nervnom sistemu. Na bazi njihovih struktura i sekvenci, efrini se dele u efrinsku klasu A (EFNA), koja se fiksira na membrani putem glikozilfosfatidilinozitolne veze, i efrinsku klasu B (EFNB), koji su transmembranski proteini. Eph familija receptora se deli u dve groupe na osnovu sličnosti njihovih sekvenci ekstracelularnog domena i njihovog afiniteta vezivanja liganda efrina A i efrina B. Efrinski receptori su najveća podgrupa receptora tirozinske kinazne (RTK) familije. Protein kodiran ovim genom je receptor za efrinske-B članove familije.^[2][3]

Reference

1. Bennett BD, Wang Z, Kuang WJ, Wang A, Groopman JE, Goeddel DV, Scadden DT (Jun 1994). „Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily”. J Biol Chem 269 (19): 14211–8. PMID 8188704. 
2. „Entrez Gene: EPHB4 EPH receptor B4”. 
3. Gerety SS, Wang HU, Chen ZF, Anderson DJ (1999). „Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development.”. Mol. Cell 4 (3): 403–14. DOI:10.1016/S1097-2765(00)80342-1. PMID 10518221. 

Literatura

• Flanagan JG, Vanderhaeghen P (1998). „The ephrins and Eph receptors in neural development.”. Annu. Rev. Neurosci. 21: 309–45. DOI:10.1146/annurev.neuro.21.1.309. PMID 9530499. 
• Zhou R (1998). „The Eph family receptors and ligands.”. Pharmacol. Ther. 77 (3): 151–81. DOI:10.1016/S0163-7258(97)00112-5. PMID 9576626. 
• Holder N, Klein R (1999). „Eph receptors and ephrins: effectors of morphogenesis.”. Development 126 (10): 2033–44. PMID 10207129. 
• Wilkinson DG (2000). „Eph receptors and ephrins: regulators of guidance and assembly.”. Int. Rev. Cytol. 196: 177–244. DOI:10.1016/S0074-7696(00)96005-4. PMID 10730216. 
• Xu Q, Mellitzer G, Wilkinson DG (2001). „Roles of Eph receptors and ephrins in segmental patterning.”. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. DOI:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993. 
• Wilkinson DG (2001). „Multiple roles of EPH receptors and ephrins in neural development.”. Nat. Rev. Neurosci. 2 (3): 155–64. DOI:10.1038/35058515. PMID 11256076. 
• Andres AC, Reid HH, Zürcher G, et al. (1994). „Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis.”. Oncogene 9 (5): 1461–7. PMID 8152808. 
• Berclaz G, Andres AC, Albrecht D, et al. (1996). „Expression of the receptor protein tyrosine kinase myk-1/htk in normal and malignant mammary epithelium.”. Biochem. Biophys. Res. Commun. 226 (3): 869–75. DOI:10.1006/bbrc.1996.1442. PMID 8831703. 
• Ephnomenclaturecommittee, (1997). „Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee.”. Cell 90 (3): 403–4. DOI:10.1016/S0092-8674(00)80500-0. PMID 9267020. 
• Nikolova Z, Djonov V, Zuercher G, et al. (1998). „Cell-type specific and estrogen dependent expression of the receptor tyrosine kinase EphB4 and its ligand ephrin-B2 during mammary gland morphogenesis.”. J. Cell. Sci. 111 (18): 2741–51. PMID 9718367. 
• Tang XX, Brodeur GM, Campling BG, Ikegaki N (1999). „Coexpression of transcripts encoding EPHB receptor protein tyrosine kinases and their ephrin-B ligands in human small cell lung carcinoma.”. Clin. Cancer Res. 5 (2): 455–60. PMID 10037197. 
• Dalva MB, Takasu MA, Lin MZ, et al. (2001). „EphB receptors interact with NMDA receptors and regulate excitatory synapse formation.”. Cell 103 (6): 945–56. DOI:10.1016/S0092-8674(00)00197-5. PMID 11136979. 
• Wilson MD, Riemer C, Martindale DW, et al. (2001). „Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5.”. Nucleic Acids Res. 29 (6): 1352–65. DOI:10.1093/nar/29.6.1352. PMC 29746. PMID 11239002.