Tirozinska proteinska kinaza HCK

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HCK proto-onkogen, Src familija tirozinskih kinaza
PDB prikaz baziran na 1ad5.
Dostupne strukture
1AD5, 1BU1, 1QCF, 2C0I, 2C0O, 2C0T, 2HCK, 2HK5, 2OI3, 2OJ2, 3HCK, 3NHN, 3RBB, 3REA, 3REB, 3VRY, 3VRZ, 3VS0, 3VS1, 3VS2, 3VS3, 3VS4, 3VS5, 3VS6, 3VS7, 4HCK, 4LUD, 4LUE, 4ORZ, 5HCK
Identifikatori
Simboli	HCK; JTK9; p59Hck; p61Hck
Vanjski ID	OMIM: 142370 MGI: 96052 HomoloGene: 20489 GeneCards: HCK Gene
EC broj	2.7.10.2
Ontologija gena Molekulska funkcija • aktivnost proteinske tirozinske kinaze • aktivnost nemembranske proteinske tirozinske kinaze • proteinsko vezivanje Ćelijska komponenta • nukleus • lizozom • Goldžijev aparat Biološki proces • imunski respons koji obuhvata leukocitnu migraciju • aktivirajući prenos signala urođenog imunskog responsa • proteinska fosforilacija
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	3055	15162
Ensembl	ENSG00000101336	ENSMUSG00000003283
UniProt	P08631	P08103
Ref. Sekv. (iRNK)	NM_001172129	NM_001172117
Ref. Sekv. (protein)	NP_001165600	NP_001165588
Lokacija (UCSC)	Chr 20: 30.64 - 30.69 Mb	Chr 2: 153.11 - 153.15 Mb
PubMed pretraga	[1]	[2]

Tirozinska proteinska kinaza HCK je enzim koji je kod ljudi kodiran HCK genom.^[1]

Protein kodiran ovim genom je proteinska tirozincka kinaza koja je prodominantno izražena u hemopoetskim ćelijskim tipovima, i pripada Src familiji tirozinskih kinaza. Kodirani protein pomaže u formiranju respiratornih sprega Fc receptora. On takođe uzima učešća u neutrofilnoj migraciji i u degranulaciji neutrofila. Pozbate su dve alternativne splajsne varijante kojim se formiraju dve distinktne izoforme, koje imaju različite podćelijske lokalizacije.^[2]

Interakcije

HCK formira interakcije sa BCR genom,^[3][4] ELMO1,^[5] Cbl genom,^[6][7] RAS p21 proteinski aktivator 1,^[8] RASA3,^[8] receptorom faktora stimulacije granulocitnih kolonija,^[9] ADAM15^[10] i RAPGEF1.^[11]

Reference

1. Quintrell N, Lebo R, Varmus H, Bishop JM, Pettenati MJ, Le Beau MM, Diaz MO, Rowley JD (August 1987). „Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells”. Mol Cell Biol 7 (6): 2267–75. PMC 365351. PMID 3496523. 
2. „Entrez Gene: HCK hemopoietic cell kinase”. 
3. Stanglmaier, M; Warmuth M; Kleinlein I; Reis S; Hallek M (February 2003). „The interaction of the Bcr-Abl tyrosine kinase with the Src kinase Hck is mediated by multiple binding domains”. Leukemia (England) 17 (2): 283–9. DOI:10.1038/sj.leu.2402778. ISSN 0887-6924. PMID 12592324. 
4. Lionberger, J M; Wilson M B; Smithgall T E (June 2000). „Transformation of myeloid leukemia cells to cytokine independence by Bcr-Abl is suppressed by kinase-defective Hck”. J. Biol. Chem. (UNITED STATES) 275 (24): 18581–5. DOI:10.1074/jbc.C000126200. ISSN 0021-9258. PMID 10849448. 
5. Scott, Margaret Porter; Zappacosta Francesca; Kim Eun Young; Annan Roland S; Miller W Todd (August 2002). „Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1”. J. Biol. Chem. (United States) 277 (31): 28238–46. DOI:10.1074/jbc.M202783200. ISSN 0021-9258. PMID 12029088. 
6. Howlett, Christopher J; Robbins Stephen M (March 2002). „Membrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular transformation”. Oncogene (England) 21 (11): 1707–16. DOI:10.1038/sj.onc.1205228. ISSN 0950-9232. PMID 11896602. 
7. Howlett, C J; Bisson S A; Resek M E; Tigley A W; Robbins S M (April 1999). „The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase”. Biochem. Biophys. Res. Commun. (UNITED STATES) 257 (1): 129–38. DOI:10.1006/bbrc.1999.0427. ISSN 0006-291X. PMID 10092522. 
8. Briggs, S D; Bryant S S; Jove R; Sanderson S D; Smithgall T E (June 1995). „The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck”. J. Biol. Chem. (UNITED STATES) 270 (24): 14718–24. DOI:10.1074/jbc.270.24.14718. ISSN 0021-9258. PMID 7782336. 
9. Ward, A C; Monkhouse J L; Csar X F; Touw I P; Bello P A (October 1998). „The Src-like tyrosine kinase Hck is activated by granulocyte colony-stimulating factor (G-CSF) and docks to the activated G-CSF receptor”. Biochem. Biophys. Res. Commun. (UNITED STATES) 251 (1): 117–23. DOI:10.1006/bbrc.1998.9441. ISSN 0006-291X. PMID 9790917. 
10. Poghosyan, Zaruhi; Robbins Stephen M; Houslay Miles D; Webster Ailsa; Murphy Gillian; Edwards Dylan R (February 2002). „Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases”. J. Biol. Chem. (United States) 277 (7): 4999–5007. DOI:10.1074/jbc.M107430200. ISSN 0021-9258. PMID 11741929. 
11. Shivakrupa, R; Radha Vegesna; Sudhakar Ch; Swarup Ghanshyam (December 2003). „Physical and functional interaction between Hck tyrosine kinase and guanine nucleotide exchange factor C3G results in apoptosis, which is independent of C3G catalytic domain”. J. Biol. Chem. (United States) 278 (52): 52188–94. DOI:10.1074/jbc.M310656200. ISSN 0021-9258. PMID 14551197. 

Literatura

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