EPH receptor A5

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EPH receptor A5
Dostupne strukture
2R2P, 4ET7
Identifikatori
Simboli	EPHA5; CEK7; EHK-1; EHK1; EK7; HEK7; TYRO4
Vanjski ID	OMIM: 600004 MGI: 99654 HomoloGene: 55824 GeneCards: EPHA5 Gene
EC broj	2.7.10.1
Ontologija gena Molekulska funkcija • aktivnost efrinskog receptora • aktivnost GPI-veznog efrinskog receptora • aktivnosti transmembranskog efrinskog receptora Ćelijska komponenta • grubi endoplasmični retikulum • ćelijska membrana • integralna komponenta ćelijske membrane Biološki proces • aksonsko navođenje • peptidil-tirozinska fosforilacija • cAMP posredovana signalizacija
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	2044	13839
Ensembl	ENSG00000145242	ENSMUSG00000029245
UniProt	P54756	Q60629
Ref. Sekv. (iRNK)	NM_001281765	NM_007937
Ref. Sekv. (protein)	NP_001268694	NP_031963
Lokacija (UCSC)	Chr 4: 66.19 - 66.54 Mb	Chr 5: 84.06 - 84.42 Mb
PubMed pretraga	[1]	[2]

Receptor 5 efrinskog tipa A je protein koji je kod ljudi kodiran EPHA5 genom.^[1][2][3]

Ovaj gen je pripadnik grupe efrinskih receptora iz familije proteinskih turozinskih kinaza. EPH i EPH-srodni receptori uzimaju učešća u posredovanju događaja razvića, posebno u nervnom sistemu. Receptori EPH podfamilije tipično imaju jedan kinazni domen, ekstracelularni region koji sadrži domen bogat cisteinom i dva ponavljanja fibronektinskog tipa III. Efrinski receptori se dele u dve grupe na bazi sličnosti sekvenci njihovih ekstracelularnih domena i njihovih afiniteta vezivanja liganda efrina A i efrina B.^[3]

Reference

1. Ephnomenclaturecommittee (Sep 1997). „Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee”. Cell 90 (3): 403–4. DOI:10.1016/S0092-8674(00)80500-0. PMID 9267020. 
2. Spritz RA, Strunk KM, Lee ST, Lu-Kuo JM, Ward DC, Le Paslier D, Altherr MR, Dorman TE, Moir DT (Jan 1995). „A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12”. Genomics 22 (2): 431–6. DOI:10.1006/geno.1994.1405. PMID 7528718. 
3. „Entrez Gene: EPHA5 EPH receptor A5”. 

Literatura

• Zhou R (1997). „Regulation of topographic projection by the Eph family receptor Bsk (EphA5) and its ligands.”. Cell Tissue Res. 290 (2): 251–9. DOI:10.1007/s004410050929. PMID 9321686. 
• Caras IW (1997). „A link between axon guidance and axon fasciculation suggested by studies of the tyrosine kinase receptor EphA5/REK7 and its ligand ephrin-A5/AL-1.”. Cell Tissue Res. 290 (2): 261–4. DOI:10.1007/s004410050930. PMID 9321687. 
• Flanagan JG, Vanderhaeghen P (1998). „The ephrins and Eph receptors in neural development.”. Annu. Rev. Neurosci. 21: 309–45. DOI:10.1146/annurev.neuro.21.1.309. PMID 9530499. 
• Zhou R (1998). „The Eph family receptors and ligands.”. Pharmacol. Ther. 77 (3): 151–81. DOI:10.1016/S0163-7258(97)00112-5. PMID 9576626. 
• Holder N, Klein R (1999). „Eph receptors and ephrins: effectors of morphogenesis.”. Development 126 (10): 2033–44. PMID 10207129. 
• Wilkinson DG (2000). „Eph receptors and ephrins: regulators of guidance and assembly.”. Int. Rev. Cytol. 196: 177–244. DOI:10.1016/S0074-7696(00)96005-4. PMID 10730216. 
• Xu Q, Mellitzer G, Wilkinson DG (2001). „Roles of Eph receptors and ephrins in segmental patterning.”. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. DOI:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993. 
• Wilkinson DG (2001). „Multiple roles of EPH receptors and ephrins in neural development.”. Nat. Rev. Neurosci. 2 (3): 155–64. DOI:10.1038/35058515. PMID 11256076. 
• Fox GM, Holst PL, Chute HT, et al. (1995). „cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases.”. Oncogene 10 (5): 897–905. PMID 7898931. 
• Davis S, Gale NW, Aldrich TH, et al. (1994). „Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity.”. Science 266 (5186): 816–9. DOI:10.1126/science.7973638. PMID 7973638. 
• Gale NW, Holland SJ, Valenzuela DM, et al. (1996). „Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.”. Neuron 17 (1): 9–19. DOI:10.1016/S0896-6273(00)80276-7. PMID 8755474. 
• Miescher GC, Taylor V, Olivieri G, et al. (1997). „Extensive splice variation and localization of the EHK-1 receptor tyrosine kinase in adult human brain and glial tumors.”. Brain Res. Mol. Brain Res. 46 (1-2): 17–24. DOI:10.1016/S0169-328X(96)00268-9. PMID 9191074. 
• Stein E, Savaskan NE, Ninnemann O, et al. (1999). „A role for the Eph ligand ephrin-A3 in entorhino-hippocampal axon targeting.”. J. Neurosci. 19 (20): 8885–93. PMID 10516308.