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Receptor insulinu sličnog faktora rasta 2‎
	; PDB prikaz baziran na 1e6f.
Dostupne strukture
	1E6F, 1GP0, 1GP3, 1GQB, 1JWG, 1LF8, 2CNJ, 2L29, 2L2A, 2V5N, 2V5O, 2V5P
Identifikatori
Simboli	IGF2R; CD222; CIMPR; M6P-R; MPR1; MPRI
Vanjski ID	OMIM: 147280 MGI: 96435 HomoloGene: 676 GeneCards: IGF2R Gene
Ontologija gena
Molekularna funkcija	• glikoproteinsko vezivanje; • receptorksa aktivnost; • aktivnost aktiviranog receptora insulinu sličnog faktora rasta;
Celularna komponenta	• lizozomalna membrana; • endozom; • integralno sa ćelijskom membranom;
Biološki proces	• receptorom posredovana endocitoza; • prenos signala; • signalni put receptora insulinu sličnog faktora rasta;
Pregled RNK izražavanja
	podaci
Ortolozi

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Receptor insulinu sličnog faktora rasta 2 (IGF2R, katjionski nezavisni receptor manoza-6-fosfata, CI-MPR) je protein koji je kod ljudi kodiran IGF2R genom.^[1]^[2] IGF2R je multifunkcionalni proteinski receptor za koji se vezuje insulinu sličan faktor rasta 2 (IGF2) na ćelijskoj površini i manoza-6-fosfat (M6P)-obeležene proteine u trans-Goldžijevom apararu.^[2]

Interakcije

Receptor insulinu sličnog faktora rasta 2 formira interakcije sa M6PRBP1.^[3]^[4]

Reference

↑ Oshima A, Nolan CM, Kyle JW, Grubb JH, Sly WS (February 1988). „The human cation-independent mannose 6-phosphate receptor. Cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells”. J. Biol. Chem. 263 (5): 2553–62. PMID 2963003.
↑ ^2,0 ^2,1 Laureys G, Barton DE, Ullrich A, Francke U (October 1988). „Chromosomal mapping of the gene for the type II insulin-like growth factor receptor/cation-independent mannose 6-phosphate receptor in man and mouse”. Genomics 3 (3): 224–9. DOI:10.1016/0888-7543(88)90083-3. PMID 2852162.
↑ Díaz E, Pfeffer SR (May 1998). „TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking”. Cell 93 (3): 433–43. DOI:10.1016/S0092-8674(00)81171-X. PMID 9590177.
↑ Orsel JG, Sincock PM, Krise JP, Pfeffer SR (August 2000). „Recognition of the 300-kDa mannose 6-phosphate receptor cytoplasmic domain by 47-kDa tail-interacting protein”. Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9047–51. DOI:10.1073/pnas.160251397. PMC 16819. PMID 10908666.

Literatura

O'Dell SD, Day IN (1998). „Insulin-like growth factor II (IGF-II)”. Int. J. Biochem. Cell Biol. 30 (7): 767–71. DOI:10.1016/S1357-2725(98)00048-X. PMID 9722981.
Hawkes C, Kar S (2004). „The insulin-like growth factor-II/mannose-6-phosphate receptor: structure, distribution and function in the central nervous system”. Brain Res. Brain Res. Rev. 44 (2–3): 117–40. DOI:10.1016/j.brainresrev.2003.11.002. PMID 15003389.
Scott CD, Firth SM (2005). „The role of the M6P/IGF-II receptor in cancer: tumor suppression or garbage disposal?”. Horm. Metab. Res. 36 (5): 261–71. DOI:10.1055/s-2004-814477. PMID 15156403.
Antoniades HN, Galanopoulos T, Neville-Golden J, Maxwell M (1992). „Expression of insulin-like growth factors I and II and their receptor mRNAs in primary human astrocytomas and meningiomas; in vivo studies using in situ hybridization and immunocytochemistry”. Int. J. Cancer 50 (2): 215–22. DOI:10.1002/ijc.2910500210. PMID 1370435.
Zhou J, Bondy C (1992). „Insulin-like growth factor-II and its binding proteins in placental development”. Endocrinology 131 (3): 1230–40. DOI:10.1210/en.131.3.1230. PMID 1380437.
Morgan DO, Edman JC, Standring DN, et al. (1987). „Insulin-like growth factor II receptor as a multifunctional binding protein”. Nature 329 (6137): 301–7. DOI:10.1038/329301a0. PMID 2957598.
Oshima A, Nolan CM, Kyle JW, et al. (1988). „The human cation-independent mannose 6-phosphate receptor. Cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells”. J. Biol. Chem. 263 (5): 2553–62. PMID 2963003.
De Souza AT, Hankins GR, Washington MK, et al. (1996). „M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity”. Nat. Genet. 11 (4): 447–9. DOI:10.1038/ng1295-447. PMID 7493029.
Ilvesmäki V, Blum WF, Voutilainen R (1994). „Insulin-like growth factor binding proteins in the human adrenal gland”. Mol. Cell. Endocrinol. 97 (1–2): 71–9. DOI:10.1016/0303-7207(93)90212-3. PMID 7511544.
De Souza AT, Hankins GR, Washington MK, et al. (1995). „Frequent loss of heterozygosity on 6q at the mannose 6-phosphate/insulin-like growth factor II receptor locus in human hepatocellular tumors”. Oncogene 10 (9): 1725–9. PMID 7753549.
Schmidt B, Kiecke-Siemsen C, Waheed A, et al. (1995). „Localization of the insulin-like growth factor II binding site to amino acids 1508-1566 in repeat 11 of the mannose 6-phosphate/insulin-like growth factor II receptor”. J. Biol. Chem. 270 (25): 14975–82. DOI:10.1074/jbc.270.25.14975. PMID 7797478.
Rao PH, Murty VV, Gaidano G, et al. (1994). „Subregional mapping of 8 single copy loci to chromosome 6 by fluorescence in situ hybridization”. Cytogenet. Cell Genet. 66 (4): 272–3. DOI:10.1159/000133710. PMID 8162705.
Ishiwata T, Bergmann U, Kornmann M, et al. (1997). „Altered expression of insulin-like growth factor II receptor in human pancreatic cancer”. Pancreas 15 (4): 367–73. DOI:10.1097/00006676-199711000-00006. PMID 9361090.
Tikkanen R, Peltola M, Oinonen C, et al. (1998). „Several cooperating binding sites mediate the interaction of a lysosomal enzyme with phosphotransferase”. EMBO J. 16 (22): 6684–93. DOI:10.1093/emboj/16.22.6684. PMC 1170273. PMID 9362483.
Nykjaer A, Christensen EI, Vorum H, et al. (1998). „Mannose 6-Phosphate/Insulin-like Growth Factor–II Receptor Targets the Urokinase Receptor to Lysosomes via a Novel Binding Interaction”. J. Cell Biol. 141 (3): 815–28. DOI:10.1083/jcb.141.3.815. PMC 2132758. PMID 9566979.
Díaz E, Pfeffer SR (1998). „TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking”. Cell 93 (3): 433–43. DOI:10.1016/S0092-8674(00)81171-X. PMID 9590177.
Wan L, Molloy SS, Thomas L, et al. (1998). „PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization”. Cell 94 (2): 205–16. DOI:10.1016/S0092-8674(00)81420-8. PMID 9695949.
Killian JK, Jirtle RL (1999). „Genomic structure of the human M6P/IGF2 receptor”. Mamm. Genome 10 (1): 74–7. DOI:10.1007/s003359900947. PMID 9892739.
Kumar S, Hand AT, Connor JR, et al. (1999). „Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions”. J. Biol. Chem. 274 (24): 17123–31. DOI:10.1074/jbc.274.24.17123. PMID 10358067.

Povezano

Spoljašnje veze

MeSH Insulin-Like-Growth-Factor+II+Receptor

[pmid2963003-1] Oshima A, Nolan CM, Kyle JW, Grubb JH, Sly WS (February 1988). „The human cation-independent mannose 6-phosphate receptor. Cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells”. J. Biol. Chem. 263 (5): 2553–62. PMID 2963003.

[pmid2852162-2] 2,0 ^2,1 Laureys G, Barton DE, Ullrich A, Francke U (October 1988). „Chromosomal mapping of the gene for the type II insulin-like growth factor receptor/cation-independent mannose 6-phosphate receptor in man and mouse”. Genomics 3 (3): 224–9. DOI:10.1016/0888-7543(88)90083-3. PMID 2852162.

[pmid9590177-3] Díaz E, Pfeffer SR (May 1998). „TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking”. Cell 93 (3): 433–43. DOI:10.1016/S0092-8674(00)81171-X. PMID 9590177.

[pmid10908666-4] Orsel JG, Sincock PM, Krise JP, Pfeffer SR (August 2000). „Recognition of the 300-kDa mannose 6-phosphate receptor cytoplasmic domain by 47-kDa tail-interacting protein”. Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9047–51. DOI:10.1073/pnas.160251397. PMC 16819. PMID 10908666.

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