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Receptor 1 faktora stimulacije kolonija
	; Prikaz baziran na PDB 2I0V.
Dostupne strukture
	2I0V, 2I0Y, 2I1M, 2OGV, 3BEA, 3DPK, 3KRJ, 3KRL, 3LCD, 3LCO, 4DKD, 4HW7
Identifikatori
Simboli	CSF1R; C-FMS; CD115; CSF-1R; CSFR; FIM2; FMS; HDLS; M-CSF-R
Vanjski ID	OMIM: 164770 MGI: 1339758 HomoloGene: 3817 GeneCards: CSF1R Gene
EC broj	2.7.10.1
Ontologija gena
Molekulska funkcija	• aktivnost receptora faktora stimulacije makrofagne kolonije; • ATP vezivanje; • vezivanje proteinske fosfataze;
Ćelijska komponenta	• ćelijska membrana; • integralna komponenta ćelijske membrane; • ćelijska površina;
Biološki proces	• pozitivna regulacija proteinske fosforilacije; • inflamatorni respons; • prenos signala;
Pregled RNK izražavanja
	podaci
Ortolozi

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Receptor 1 faktora stimulacije kolonija (CSF1R, receptor faktora stimulacije makrofagnih kolonija, M-CSFR, CD115, Klaster Diferencijacije 115), je protein sa ćelijske površine koji je kod ljudi kodiran CSF1R genom.^[1]^[2] On je receptor za citokin sa imenom faktor stimulacije kolonija 1.

Interakcije

Ovaj receptor formira interakcije sa:

Cbl gen,^[3]
FYN,^[4]
Grb2,^[5]
Supresor citokinske signalizacije 1,^[6]

Povezano

Klaster diferencijacije

Reference

↑ EntrezGene 1436
↑ Galland F, Stefanova M, Lafage M, Birnbaum D (1992). „Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15→q23”. Cytogenet. Cell Genet. 60 (2): 114–6. DOI:10.1159/000133316. PMID 1611909.
↑ Mancini A, Koch A, Wilms R, Tamura T (April 2002). „c-Cbl associates directly with the C-terminal tail of the receptor for the macrophage colony-stimulating factor, c-Fms, and down-modulates this receptor but not the viral oncogene v-Fms”. J. Biol. Chem. 277 (17): 14635–40. DOI:10.1074/jbc.M109214200. PMID 11847211.
↑ Courtneidge SA, Dhand R, Pilat D, Twamley GM, Waterfield MD, Roussel MF (March 1993). „Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor”. EMBO J. 12 (3): 943–50. PMC 413295. PMID 7681396.
↑ Mancini A, Niedenthal R, Joos H, Koch A, Trouliaris S, Niemann H, Tamura T (September 1997). „Identification of a second Grb2 binding site in the v-Fms tyrosine kinase”. Oncogene 15 (13): 1565–72. DOI:10.1038/sj.onc.1201518. PMID 9380408.
↑ Bourette RP, De Sepulveda P, Arnaud S, Dubreuil P, Rottapel R, Mouchiroud G (June 2001). „Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signal”. J. Biol. Chem. 276 (25): 22133–9. DOI:10.1074/jbc.M101878200. PMID 11297560.

Literatura

Rettenmier CW, Roussel MF, Sherr CJ (1988). „The colony-stimulating factor 1 (CSF-1) receptor (c-fms proto-oncogene product) and its ligand”. J. Cell Sci. Suppl. 9: 27–44. PMID 2978516.
Stanley ER, Berg KL, Einstein DB, Lee PS, Pixley FJ, Wang Y, Yeung YG (January 1997). „Biology and action of colony--stimulating factor-1”. Mol. Reprod. Dev. 46 (1): 4–10. DOI:10.1002/(SICI)1098-2795(199701)46:1<4::AID-MRD2>3.0.CO;2-V. PMID 8981357.
Gout I, Dhand R, Panayotou G, Fry MJ, Hiles I, Otsu M, Waterfield MD (December 1992). „Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system”. Biochem. J. 288 ( Pt 2): 395–405. PMC 1132024. PMID 1334406.
Boultwood J, Rack K, Kelly S, Madden J, Sakaguchi AY, Wang LM, Oscier DG, Buckle VJ, Wainscoat JS (July 1991). „Loss of both CSF1R (FMS) alleles in patients with myelodysplasia and a chromosome 5 deletion”. Proc. Natl. Acad. Sci. U.S.A. 88 (14): 6176–80. DOI:10.1073/pnas.88.14.6176. PMC 52045. PMID 1829836.
Roussel MF, Cleveland JL, Shurtleff SA, Sherr CJ (September 1991). „Myc rescue of a mutant CSF-1 receptor impaired in mitogenic signalling”. Nature 353 (6342): 361–3. DOI:10.1038/353361a0. PMID 1833648.
Reedijk M, Liu XQ, Pawson T (November 1990). „Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor”. Mol. Cell. Biol. 10 (11): 5601–8. PMC 361316. PMID 2172781.
Sherr CJ, Rettenmier CW, Sacca R, Roussel MF, Look AT, Stanley ER (July 1985). „The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1”. Cell 41 (3): 665–76. DOI:10.1016/S0092-8674(85)80047-7. PMID 2408759.
Coussens L, Van Beveren C, Smith D, Chen E, Mitchell RL, Isacke CM, Verma IM, Ullrich A (1986). „Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus”. Nature 320 (6059): 277–80. DOI:10.1038/320277a0. PMID 2421165.
Hampe A, Shamoon BM, Gobet M, Sherr CJ, Galibert F (1989). „Nucleotide sequence and structural organization of the human FMS proto-oncogene”. Oncogene Res. 4 (1): 9–17. PMID 2524025.
Visvader J, Verma IM (March 1989). „Differential transcription of exon 1 of the human c-fms gene in placental trophoblasts and monocytes”. Mol. Cell. Biol. 9 (3): 1336–41. PMC 362728. PMID 2524648.
Roberts WM, Look AT, Roussel MF, Sherr CJ (November 1988). „Tandem linkage of human CSF-1 receptor (c-fms) and PDGF receptor genes”. Cell 55 (4): 655–61. DOI:10.1016/0092-8674(88)90224-3. PMID 2846185.
Xu DQ, Guilhot S, Galibert F (May 1985). „Restriction fragment length polymorphism of the human c-fms gene”. Proc. Natl. Acad. Sci. U.S.A. 82 (9): 2862–5. DOI:10.1073/pnas.82.9.2862. JSTOR 25278. PMC 397666. PMID 2986142.
Sherr CJ, Rettenmier CW (1986). „The fms gene and the CSF-1 receptor”. Cancer Surv. 5 (2): 221–32. PMID 3022923.
Le Beau MM, Westbrook CA, Diaz MO, Larson RA, Rowley JD, Gasson JC, Golde DW, Sherr CJ (February 1986). „Evidence for the involvement of GM-CSF and FMS in the deletion (5q) in myeloid disorders”. Science 231 (4741): 984–7. DOI:10.1126/science.3484837. PMID 3484837.
Wheeler EF, Roussel MF, Hampe A, Walker MH, Fried VA, Look AT, Rettenmier CW, Sherr CJ (August 1986). „The amino-terminal domain of the v-fms oncogene product includes a functional signal peptide that directs synthesis of a transforming glycoprotein in the absence of feline leukemia virus gag sequences”. J. Virol. 59 (2): 224–33. PMC 253070. PMID 3525854.
Verbeek JS, Roebroek AJ, van den Ouweland AM, Bloemers HP, Van de Ven WJ (February 1985). „Human c-fms proto-oncogene: comparative analysis with an abnormal allele”. Mol. Cell. Biol. 5 (2): 422–6. PMC 366728. PMID 3974576.
Lee AW, Nienhuis AW (September 1990). „Mechanism of kinase activation in the receptor for colony-stimulating factor 1”. Proc. Natl. Acad. Sci. U.S.A. 87 (18): 7270–4. DOI:10.1073/pnas.87.18.7270. PMC 54725. PMID 2169623.

Vanjske veze

MeSH CSF1R+protein,+human

[entrez-1] EntrezGene 1436

[pmid1611909-2] Galland F, Stefanova M, Lafage M, Birnbaum D (1992). „Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15→q23”. Cytogenet. Cell Genet. 60 (2): 114–6. DOI:10.1159/000133316. PMID 1611909.

[pmid11847211-3] Mancini A, Koch A, Wilms R, Tamura T (April 2002). „c-Cbl associates directly with the C-terminal tail of the receptor for the macrophage colony-stimulating factor, c-Fms, and down-modulates this receptor but not the viral oncogene v-Fms”. J. Biol. Chem. 277 (17): 14635–40. DOI:10.1074/jbc.M109214200. PMID 11847211.

[pmid7681396-4] Courtneidge SA, Dhand R, Pilat D, Twamley GM, Waterfield MD, Roussel MF (March 1993). „Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor”. EMBO J. 12 (3): 943–50. PMC 413295. PMID 7681396.

[pmid9380408-5] Mancini A, Niedenthal R, Joos H, Koch A, Trouliaris S, Niemann H, Tamura T (September 1997). „Identification of a second Grb2 binding site in the v-Fms tyrosine kinase”. Oncogene 15 (13): 1565–72. DOI:10.1038/sj.onc.1201518. PMID 9380408.

[pmid11297560-6] Bourette RP, De Sepulveda P, Arnaud S, Dubreuil P, Rottapel R, Mouchiroud G (June 2001). „Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signal”. J. Biol. Chem. 276 (25): 22133–9. DOI:10.1074/jbc.M101878200. PMID 11297560.

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