Oxazepam

Oxazepam
Alerta sobre risco à saúde
Nome IUPAC (RS)-9-chloro-4-hydroxy-6-phenyl-
2,5-diazabicyclo[5.4.0]undeca-
5,8,10,12-tetraen-3-one
Identificadores
Número CAS 604-75-1
PubChem 4616
DrugBank APRD01152
ChemSpider 4455
Código ATC N05BA04
SMILES
InChI
1/C15H11ClN2O2/c16-10-6-7-12-11(8-10)13(9-4-2-1-3-5-9)18-15(20)14(19)17-12/h1-8,15,20H,(H,17,19)
Propriedades
Fórmula química C15H11ClN2O2
Massa molar 286.7 g mol-1
Farmacologia
Biodisponibilidade 95.5%
Via(s) de administração Oral
Metabolismo Hepático
Meia-vida biológica 4-14 houras
Excreção Renal
Classificação legal Prescription Only (S4) (AU)



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Compostos relacionados
Benzodiazepínicos relacionados Nordazepam (sem a hidroxila na posição 3)
Demoxepam (isômero, hidroxila na posição 4)
Temazepam (um metil no N da posição 1)
Página de dados suplementares
Estrutura e propriedades n, εr, etc.
Dados termodinâmicos Phase behaviour
Solid, liquid, gas
Dados espectrais UV, IV, RMN, EM
Exceto onde denotado, os dados referem-se a
materiais sob condições normais de temperatura e pressão

Referências e avisos gerais sobre esta caixa.
Alerta sobre risco à saúde.

Oxazepam é uma substância utilizada como medicamento pertencente ao grupo e sub-grupos:

Indicações

  • Perturbações da ansiedade e sintomas ansiosos.

Reacções adversas

Contraindicações e precauções

Interacções

Deve ser evitado o uso concomitante de álcool e medicamentos depressores do Sistema Nervoso Central..

Farmacocinética

  • Oxazepam atravessa a barreira placentária e aparece em pequenas doses no leite materno.
  • É absorvido no trato gastrointestinal.
  • Não é necessário fazer ajustes na posologia em doentes com insuficiência renal.
  • Em doentes com hipotiroidismo pode ser necessário alterar a dosagem a administrar.
  • O oxazepam atinge o pico de concentração no plasma ao fim de duas horas após a sua administração.
  • 85% a 97% do oxazepam liga-se às proteínas plasmáticas.

Excreção


Ver também

Referências

  1. «Oxazepam». Encyclopædia Britannica Online (em inglês). Consultado em 3 de outubro de 2020 
  2. «Oxazepam» (em inglês). PubChem. Consultado em 3 de outubro de 2020 

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