PROFILBARU.COM

ZNF239
Identifiers
Aliases	ZNF239, HOK-2, MOK2, zinc finger protein 239
External IDs	OMIM: 601069; MGI: 1306812; HomoloGene: 68480; GeneCards: ZNF239; OMA:ZNF239 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	43,574,618 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	117,873,291 bp
RNA expression pattern
	Top expressed in
	gonad; ; endothelial cell; ; testicle; ; ganglionic eminence; ; ventricular zone; ; body of pancreas; ; islet of Langerhans; ; stromal cell of endometrium; ; prefrontal cortex; ; smooth muscle tissue;
	Top expressed in
	Ileal epithelium; ; cingulate gyrus; ; CA3 field; ; superior frontal gyrus; ; dentate gyrus; ; entorhinal cortex; ; primary visual cortex; ; primary motor cortex; ; perirhinal cortex; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; protein binding; metal ion binding; nucleic acid binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA binding;
Cellular component	nucleus;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	8187
	22685
	ENSG00000196793
	ENSMUSG00000042097
	Q16600
	P24399
NM_001099282; NM_001099283; NM_001099284; NM_005674; NM_001324347;
	NM_001324348; NM_001324349; NM_001324350; NM_001324351; NM_001324352; NM_001324353
	NM_001001792; NM_008616; NM_001360938
NP_001092752; NP_001092753; NP_001092754; NP_001311276; NP_001311277;
	NP_001311278; NP_001311279; NP_001311280; NP_001311281; NP_001311282; NP_005665
	NP_001001792; NP_032642; NP_001347867
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein 239 is a protein that in humans is encoded by the ZNF239 gene.^[5]^[6]^[7]

Function

MOK2 proteins are DNA- and RNA-binding proteins that are mainly associated with nuclear RNP components, including the nucleoli and extranucleolar structures.^[7]^[8]

Interactions

ZNF239 has been shown to interact with LMNA.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196793 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042097 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Arranz V, Kress M, Ernoult-Lange M (Jan 1996). "Localization of zinc finger Mok2 gene to mouse chromosome 6, a new region of homology with human chromosome 19". Mammalian Genome. 7 (1): 77–8. doi:10.1007/s003359900020. PMID 8903737. S2CID 36851320.
^ Ernoult-Lange M, Arranz V, Le Coniat M, Berger R, Kress M (Dec 1995). "Human and mouse Krüppel-like (MOK2) orthologue genes encode two different zinc finger proteins". Journal of Molecular Evolution. 41 (6): 784–94. Bibcode:1995JMolE..41..784E. doi:10.1007/bf00173158. PMID 8587123. S2CID 22955858.
^ ^a ^b "Entrez Gene: ZNF239 zinc finger protein 239".
^ Arranz V, Harper F, Florentin Y, Puvion E, Kress M, Ernoult-Lange M (Apr 1997). "Human and mouse MOK2 proteins are associated with nuclear ribonucleoprotein components and bind specifically to RNA and DNA through their zinc finger domains". Molecular and Cellular Biology. 17 (4): 2116–26. doi:10.1128/mcb.17.4.2116. PMC 232059. PMID 9121460.
^ Dreuillet C, Tillit J, Kress M, Ernoult-Lange M (Nov 2002). "In vivo and in vitro interaction between human transcription factor MOK2 and nuclear lamin A/C". Nucleic Acids Research. 30 (21): 4634–42. doi:10.1093/nar/gkf587. PMC 135794. PMID 12409453.

\* Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.