Thyroid hormone receptor alpha

THRA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1NAV, 2H77, 2H79, 3HZF, 3ILZ, 3JZB, 4LNW, 4LNX
Identifiers
Aliases	THRA, AR7, CHNG6, EAR7, ERB-T-1, ERBA, ERBA1, NR1A1, THRA1, THRA2, c-ERBA-1, thyroid hormone receptor, alpha, thyroid hormone receptor alpha, TRalpha
External IDs	OMIM: 190120; MGI: 98742; HomoloGene: 37747; GeneCards: THRA; OMA:THRA - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	40,093,867 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	98,659,832 bp
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; middle frontal gyrus; ; Amygdala; ; caudate nucleus; ; putamen; ; right frontal lobe; ; cingulate gyrus; ; anterior cingulate cortex; ; cerebellar hemisphere; ; right hemisphere of cerebellum;
	Top expressed in
	entorhinal cortex; ; dentate gyrus of hippocampal formation granule cell; ; perirhinal cortex; ; CA3 field; ; primary visual cortex; ; superior frontal gyrus; ; neural layer of retina; ; nucleus of stria terminalis; ; subiculum; ; hippocampus proper;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transcription cis-regulatory region binding; protein binding; single-stranded RNA binding; zinc ion binding; chromatin DNA binding; nuclear receptor activity; steroid receptor RNA activator RNA binding; transcription factor binding; TBP-class protein binding; steroid hormone receptor activity; DNA binding; protein domain specific binding; sequence-specific DNA binding; metal ion binding; DNA-binding transcription factor activity; thyroid hormone binding; DNA-binding transcription factor activity, RNA polymerase II-specific; protein-containing complex binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; nuclear receptor coactivator activity; signaling receptor activity;
Cellular component	cytoplasm; nucleoplasm; nucleus; cytosol; RNA polymerase II transcription regulator complex;
Biological process	regulation of transcription by RNA polymerase II; response to cold; cytoplasmic sequestering of transcription factor; hormone-mediated signaling pathway; regulation of thyroid hormone mediated signaling pathway; thyroid gland development; regulation of transcription, DNA-templated; ossification; female courtship behavior; cartilage condensation; negative regulation of RNA polymerase II transcription preinitiation complex assembly; type I pneumocyte differentiation; transcription, DNA-templated; steroid hormone mediated signaling pathway; transcription by RNA polymerase II; regulation of lipid catabolic process; regulation of heart contraction; animal organ morphogenesis; positive regulation of female receptivity; learning or memory; regulation of myeloid cell apoptotic process; positive regulation of transcription by RNA polymerase II; transcription initiation from RNA polymerase II promoter; erythrocyte differentiation; negative regulation of DNA-templated transcription, initiation; positive regulation of myotube differentiation; negative regulation of transcription, DNA-templated; intracellular receptor signaling pathway; negative regulation of transcription by RNA polymerase II; thyroid hormone mediated signaling pathway; multicellular organism development; brain development; cell differentiation; response to lipid; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	7067
	21833
	ENSG00000126351
	ENSMUSG00000058756
	P10827
	P63058
	NM_199334; NM_001190918; NM_001190919; NM_003250
	NM_178060; NM_001313983
	NP_001177847; NP_001177848; NP_003241; NP_955366
	NP_001300912; NP_835161
	Wikidata
View/Edit Human	View/Edit Mouse

Thyroid hormone receptor alpha (TR-alpha) also known as nuclear receptor subfamily 1, group A, member 1 (NR1A1), is a nuclear receptor protein that in humans is encoded by the THRA gene.^[5]^[6]^[7]

Function

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported.^[5]

Role in pathology

Mutations of the THRA gene may cause nongoitrous congenital hypothyroidism-6, a subtype of congenital hypothyroidism.

Interactions

THR1 has been shown to interact with:

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000126351 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058756 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: THRA thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)".
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^ Lee SK, Na SY, Jung SY, Choi JE, Jhun BH, Cheong J, Meltzer PS, Lee YC, Lee JW (Jun 2000). "Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2". Molecular Endocrinology. 14 (6): 915–25. doi:10.1210/mend.14.6.0471. PMID 10847592.
^ Chang KH, Chen Y, Chen TT, Chou WH, Chen PL, Ma YY, Yang-Feng TL, Leng X, Tsai MJ, O'Malley BW, Lee WH (Aug 1997). "A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein". Proceedings of the National Academy of Sciences of the United States of America. 94 (17): 9040–5. Bibcode:1997PNAS...94.9040C. doi:10.1073/pnas.94.17.9040. PMC 23019. PMID 9256431.
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