MNT (gene)

MNT
Identifiers
Aliases	MNT, MAD6, MXD6, ROX, bHLHd3, MAX network transcriptional repressor, lncRNA-HAL
External IDs	OMIM: 603039; MGI: 109150; HomoloGene: 7842; GeneCards: MNT; OMA:MNT - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.3 Start 2,384,073 bp[1] End 2,401,104 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B5|11 45.76 cM Start 74,721,746 bp[2] End 74,736,551 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 middle temporal gyrus Region I of hippocampus proper endothelial cell dorsal motor nucleus of vagus nerve Brodmann area 10 sural nerve gingival epithelium orbitofrontal cortex tendon of biceps brachii Top expressed in Rostral migratory stream motor neuron stroma of bone marrow iris ciliary body gastrula vestibular membrane of cochlear duct substantia nigra blood aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding transcription coactivator activity RNA polymerase II transcription regulatory region sequence-specific DNA binding chromatin binding protein dimerization activity DNA-binding transcription repressor activity, RNA polymerase II-specific transcription corepressor activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm Biological process multicellular organism development negative regulation of apoptotic signaling pathway regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription, DNA-templated negative regulation of cell population proliferation regulation of cell cycle positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4335 17428 Ensembl ENSG00000070444 ENSMUSG00000000282 UniProt Q99583 O08789 RefSeq (mRNA) NM_020310 NM_010813 RefSeq (protein) NP_064706 NP_034943 Location (UCSC) Chr 17: 2.38 – 2.4 Mb Chr 11: 74.72 – 74.74 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

MNT (Max-binding protein MNT) is a Max-binding protein that is encoded by the MNT gene^[5][6][7]

Function

The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. Its delta signature is 44. This protein is a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA and recruiting Sin3 corepressor proteins through its N-terminal Sin3-interaction domain ^[5][8]

Interactions

MNT (gene) has been shown to interact with MLX,^[9][10] SIN3A^[11] and MAX.^[11]

References

1. GRCh38: Ensembl release 89: ENSG00000070444 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000000282 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hurlin PJ, Quéva C, Eisenman RN (January 1997). "Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites". Genes & Development. 11 (1): 44–58. doi:10.1101/gad.11.1.44. PMID 9000049.
6. Lo Nigro C, Venesio T, Reymond A, Meroni G, Alberici P, Cainarca S, Enrico F, Stack M, Ledbetter DH, Liscia DS, Ballabio A, Carrozzo R (April 1998). "The human ROX gene: genomic structure and mutation analysis in human breast tumors". Genomics. 49 (2): 275–282. doi:10.1006/geno.1998.5241. PMID 9598315.
7. "Entrez Gene: MNT MAX binding protein".
8. Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter DH, Brent R, Ballabio A, Carrozzo R (May 1997). "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor". The EMBO Journal. 16 (10): 2892–2906. doi:10.1093/emboj/16.10.2892. PMC 1169897. PMID 9184233.
9. Cairo S, Merla G, Urbinati F, Ballabio A, Reymond A (March 2001). "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network". Human Molecular Genetics. 10 (6): 617–627. doi:10.1093/hmg/10.6.617. PMID 11230181.
10. Meroni G, Cairo S, Merla G, Messali S, Brent R, Ballabio A, Reymond A (July 2000). "Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?". Oncogene. 19 (29): 3266–3277. doi:10.1038/sj.onc.1203634. PMID 10918583.
11. Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter DH, Brent R, Ballabio A, Carrozzo R (May 1997). "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor". The EMBO Journal. 16 (10): 2892–2906. doi:10.1093/emboj/16.10.2892. PMC 1169897. PMID 9184233.

Further reading

• Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter DH, Brent R, Ballabio A, Carrozzo R (May 1997). "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor". The EMBO Journal. 16 (10): 2892–2906. doi:10.1093/emboj/16.10.2892. PMC 1169897. PMID 9184233.
• Hirotsune S, Pack SD, Chong SS, Robbins CM, Pavan WJ, Ledbetter DH, Wynshaw-Boris A (June 1997). "Genomic organization of the murine Miller-Dieker/lissencephaly region: conservation of linkage with the human region". Genome Research. 7 (6): 625–634. doi:10.1101/gr.7.6.625. PMC 310661. PMID 9199935.
• Meroni G, Cairo S, Merla G, Messali S, Brent R, Ballabio A, Reymond A (July 2000). "Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?". Oncogene. 19 (29): 3266–3277. doi:10.1038/sj.onc.1203634. PMID 10918583.
• Cairo S, Merla G, Urbinati F, Ballabio A, Reymond A (March 2001). "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network". Human Molecular Genetics. 10 (6): 617–627. doi:10.1093/hmg/10.6.617. PMID 11230181.
• Stoneley M, Spencer JP, Wright SC (February 2001). "An internal ribosome entry segment in the 5' untranslated region of the mnt gene". Oncogene. 20 (7): 893–897. doi:10.1038/sj.onc.1204157. PMID 11314024.
• Dintilhac A, Bernués J (March 2002). "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences". The Journal of Biological Chemistry. 277 (9): 7021–7028. doi:10.1074/jbc.M108417200. hdl:10261/112516. PMID 11748221.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–716. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Smith AG, Popov N, Imreh M, Axelson H, Henriksson M (August 2004). "Expression and DNA-binding activity of MYCN/Max and Mnt/Max during induced differentiation of human neuroblastoma cells". Journal of Cellular Biochemistry. 92 (6): 1282–1295. doi:10.1002/jcb.20121. PMID 15258910. S2CID 35885353.
• Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (December 2005). "Transcriptome analysis of human gastric cancer". Mammalian Genome. 16 (12): 942–954. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
• Guo XL, Pan L, Zhang XJ, Suo XH, Niu ZY, Zhang JY, Wang F, Dong ZR, Da W, Ohno R (June 2007). "Expression and mutation analysis of genes that encode the Myc antagonists Mad1, Mxi1 and Rox in acute leukaemia". Leukemia & Lymphoma. 48 (6): 1200–1207. doi:10.1080/10428190701342018. PMID 17577784. S2CID 24127330.

External links

• MNT+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.