ELK3

ELK3
Identifiers
Aliases	ELK3, ERP, NET, SAP2, SAP-2, ETS transcription factor, ETS transcription factor ELK3
External IDs	OMIM: 600247; MGI: 101762; HomoloGene: 3833; GeneCards: ELK3; OMA:ELK3 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q23.1 Start 96,194,375 bp[1] End 96,269,824 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C2|10 48.04 cM Start 93,083,276 bp[2] End 93,146,997 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell synovial joint amniotic fluid urethra visceral pleura vena cava parietal pleura oral cavity mucosa of paranasal sinus superficial temporal artery Top expressed in endothelial cell of lymphatic vessel dermis endocardial cushion left lung lobe atrioventricular valve atrium external carotid artery decidua vas deferens semi-lunar valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding transcription corepressor activity purine-rich negative regulatory element binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific Cellular component mitochondrion nucleoplasm cytoplasm nucleus Biological process transcription, DNA-templated cell differentiation wound healing regulation of transcription, DNA-templated angiogenesis signal transduction positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2004 13713 Ensembl ENSG00000111145 ENSMUSG00000008398 UniProt P41970 P41971 RefSeq (mRNA) NM_001303511 NM_005230 NM_001282967 NM_013508 NM_205536 NM_001322265 NM_001322268 RefSeq (protein) NP_001290440 NP_005221 NP_001269896 NP_001309194 NP_001309197 NP_038536 Location (UCSC) Chr 12: 96.19 – 96.27 Mb Chr 10: 93.08 – 93.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ETS domain-containing protein Elk-3 is a protein that in humans is encoded by the ELK3 gene.^[5][6]

The protein encoded by this gene is a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present.^[6]

Interactions

ELK3 has been shown to interact with TCF3.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000111145 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000008398 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shipley J, Sheer D, Dalton S, Treisman R, Patel K (Mar 1995). "Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively". Genomics. 23 (3): 710–1. doi:10.1006/geno.1994.1564. PMID 7851904.
6. "Entrez Gene: ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)".
7. Maira, S M; Wurtz J M; Wasylyk B (Nov 1996). "Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif". EMBO J. 15 (21). ENGLAND: 5849–65. doi:10.1002/j.1460-2075.1996.tb00972.x. ISSN 0261-4189. PMC 452333. PMID 8918463.

Further reading

• Sharrocks AD, Brown AL, Ling Y, Yates PR (1998). "The ETS-domain transcription factor family". Int. J. Biochem. Cell Biol. 29 (12): 1371–87. doi:10.1016/S1357-2725(97)00086-1. PMID 9570133.
• Wasylyk B, Hagman J, Gutierrez-Hartmann A (1998). "Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway". Trends Biochem. Sci. 23 (6): 213–6. doi:10.1016/S0968-0004(98)01211-0. PMID 9644975.
• Price MA, Rogers AE, Treisman R (1995). "Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET)". EMBO J. 14 (11): 2589–601. doi:10.1002/j.1460-2075.1995.tb07257.x. PMC 398373. PMID 7540136.
• Giovane A, Pintzas A, Maira SM, et al. (1994). "Net, a new ets transcription factor that is activated by Ras". Genes Dev. 8 (13): 1502–13. doi:10.1101/gad.8.13.1502. PMID 7958835.
• Maira SM, Wurtz JM, Wasylyk B (1997). "Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif". EMBO J. 15 (21): 5849–65. doi:10.1002/j.1460-2075.1996.tb00972.x. PMC 452333. PMID 8918463.
• Criqui-Filipe P, Ducret C, Maira SM, Wasylyk B (1999). "Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation". EMBO J. 18 (12): 3392–403. doi:10.1093/emboj/18.12.3392. PMC 1171419. PMID 10369679.
• Ducret C, Maira SM, Dierich A, Wasylyk B (2000). "The net repressor is regulated by nuclear export in response to anisomycin, UV, and heat shock". Mol. Cell. Biol. 19 (10): 7076–87. doi:10.1128/mcb.19.10.7076. PMC 84702. PMID 10490644.
• Ducret C, Maira SM, Lutz Y, Wasylyk B (2000). "The ternary complex factor Net contains two distinct elements that mediate different responses to MAP kinase signalling cascades". Oncogene. 19 (44): 5063–72. doi:10.1038/sj.onc.1203892. PMID 11042694.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gupta M, Sueblinvong V, Raman J, et al. (2004). "Single-stranded DNA-binding proteins PURalpha and PURbeta bind to a purine-rich negative regulatory element of the alpha-myosin heavy chain gene and control transcriptional and translational regulation of the gene expression. Implications in the repression of alpha-myosin heavy chain during heart failure". J. Biol. Chem. 278 (45): 44935–48. doi:10.1074/jbc.M307696200. PMID 12933792.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wasylyk C, Criqui-Filipe P, Wasylyk B (2005). "Sumoylation of the net inhibitory domain (NID) is stimulated by PIAS1 and has a negative effect on the transcriptional activity of Net". Oncogene. 24 (5): 820–8. doi:10.1038/sj.onc.1208226. PMID 15580297.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links

• ELK3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.