ZNF259

ZPR1
Identifiers
Aliases	ZPR1, ZNF259, ZPR1 zinc finger, GKAF
External IDs	OMIM: 603901; MGI: 1330262; HomoloGene: 2900; GeneCards: ZPR1; OMA:ZPR1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.3 Start 116,773,799 bp[1] End 116,788,039 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A5.2 Start 46,184,362 bp[2] End 46,193,941 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence right testis sperm left testis islet of Langerhans sural nerve Achilles tendon body of pancreas right lobe of liver smooth muscle tissue Top expressed in epiblast tail of embryo embryo Rostral migratory stream embryo seminiferous tubule genital tubercle muscle of thigh yolk sac morula More reference expression data BioGPS n/a
Gene ontology Molecular function receptor tyrosine kinase binding zinc ion binding metal ion binding protein binding translation initiation factor binding Cellular component cytoplasm perikaryon Cajal body cell projection growth cone nucleoplasm SMN complex axon soma nucleolus perinuclear region of cytoplasm nucleus gemini of coiled bodies Biological process cell differentiation axon development pre-mRNA catabolic process Cajal body organization mRNA processing apoptotic process involved in development positive regulation of growth inner cell mass cell proliferation cellular response to epidermal growth factor stimulus positive regulation of gene expression regulation of myelination positive regulation of transcription involved in G1/S transition of mitotic cell cycle RNA splicing spinal cord development positive regulation of RNA splicing positive regulation of protein import into nucleus cell population proliferation DNA endoreduplication microtubule cytoskeleton organization trophectodermal cell proliferation signal transduction negative regulation of motor neuron apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8882 22687 Ensembl ENSG00000109917 ENSMUSG00000032078 UniProt O75312 Q62384 RefSeq (mRNA) NM_003904 NM_001317086 NM_011752 RefSeq (protein) NP_001304015 NP_003895 NP_035882 Location (UCSC) Chr 11: 116.77 – 116.79 Mb Chr 9: 46.18 – 46.19 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger protein ZPR1 is a protein that in humans is encoded by the ZNF259 gene.^[5][6][7]

References

1. GRCh38: Ensembl release 89: ENSG00000109917 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032078 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Galcheva-Gargova Z, Konstantinov KN, Wu IH, Klier FG, Barrett T, Davis RJ (June 1996). "Binding of zinc finger protein ZPR1 to the epidermal growth factor receptor". Science. 272 (5269): 1797–802. Bibcode:1996Sci...272.1797G. doi:10.1126/science.272.5269.1797. PMID 8650580. S2CID 6851783.
6. Galcheva-Gargova Z, Gangwani L, Konstantinov KN, Mikrut M, Theroux SJ, Enoch T, Davis RJ (October 1998). "The cytoplasmic zinc finger protein ZPR1 accumulates in the nucleolus of proliferating cells". Molecular Biology of the Cell. 9 (10): 2963–71. doi:10.1091/mbc.9.10.2963. PMC 25573. PMID 9763455.
7. "Entrez Gene: ZNF259 zinc finger protein 259".

Further reading

• Gangwani L, Mikrut M, Galcheva-Gargova Z, Davis RJ (December 1998). "Interaction of ZPR1 with translation elongation factor-1alpha in proliferating cells". The Journal of Cell Biology. 143 (6): 1471–84. doi:10.1083/jcb.143.6.1471. PMC 2132977. PMID 9852145.
• Moores SL, Selfors LM, Fredericks J, Breit T, Fujikawa K, Alt FW, Brugge JS, Swat W (September 2000). "Vav family proteins couple to diverse cell surface receptors". Molecular and Cellular Biology. 20 (17): 6364–73. doi:10.1128/MCB.20.17.6364-6373.2000. PMC 86111. PMID 10938113.
• Narayanan U, Ospina JK, Frey MR, Hebert MD, Matera AG (July 2002). "SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta". Human Molecular Genetics. 11 (15): 1785–95. doi:10.1093/hmg/11.15.1785. PMC 1630493. PMID 12095920.
• Gangwani L, Flavell RA, Davis RJ (April 2005). "ZPR1 is essential for survival and is required for localization of the survival motor neurons (SMN) protein to Cajal bodies". Molecular and Cellular Biology. 25 (7): 2744–56. doi:10.1128/MCB.25.7.2744-2756.2005. PMC 1061650. PMID 15767679.
• Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, Eizirik DL, She JX, Wang CY (December 2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochemical and Biophysical Research Communications. 337 (4): 1308–18. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.
• Gangwani L (December 2006). "Deficiency of the zinc finger protein ZPR1 causes defects in transcription and cell cycle progression". The Journal of Biological Chemistry. 281 (52): 40330–40. doi:10.1074/jbc.M608165200. PMID 17068332.

External links

• ZNF259+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.