Testicular receptor 2

NR2C1
Identifiers
Aliases	NR2C1, TR2, Testicular receptor 2, nuclear receptor subfamily 2 group C member 1
External IDs	OMIM: 601529; MGI: 1352465; HomoloGene: 55731; GeneCards: NR2C1; OMA:NR2C1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q22 Start 95,020,229 bp[1] End 95,073,628 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C2|10 48.81 cM Start 93,983,885 bp[2] End 94,033,073 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere right hemisphere of cerebellum left lobe of thyroid gland right lung tibial nerve muscle of thigh sural nerve right lobe of thyroid gland right lobe of liver gastric mucosa Top expressed in spermatid spermatocyte seminal vesicula corneal stroma otic vesicle male urethra secondary oocyte genital tubercle seminiferous tubule tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding protein homodimerization activity DNA-binding transcription factor activity zinc ion binding histone deacetylase binding metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding steroid hormone receptor activity DNA-binding transcription repressor activity, RNA polymerase II-specific protein binding DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific signaling receptor activity Cellular component PML body nucleoplasm nucleus Biological process regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated positive regulation of retinoic acid receptor signaling pathway transcription initiation from RNA polymerase II promoter negative regulation of transcription, DNA-templated steroid hormone mediated signaling pathway signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7181 22025 Ensembl ENSG00000120798 ENSMUSG00000005897 UniProt P13056 Q505F1 RefSeq (mRNA) NM_001032287 NM_001127362 NM_003297 NM_011629 RefSeq (protein) NP_001027458 NP_001120834 NP_003288 NP_003288.2 NP_035759 Location (UCSC) Chr 12: 95.02 – 95.07 Mb Chr 10: 93.98 – 94.03 Mb PubMed search [3] [4]
Wikidata
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The testicular receptor 2 (TR2) also known as NR2C1 (nuclear receptor subfamily 2, group C, member 1) is protein that in humans is encoded by the NR2C1 gene.^[5][6] TR2 is a member of the nuclear receptor family of transcription factors.

Interactions

Testicular receptor 2 has been shown to interact with:

• Androgen receptor,^[7]
• Estrogen receptor alpha,^[8]
• HDAC3,^[9][10][11] and
• HDAC4.^[10][11]

See also

• Testicular receptor

References

1. GRCh38: Ensembl release 89: ENSG00000120798 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000005897 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: NR2C1 nuclear receptor subfamily 2, group C, member 1".
6. Chang C, Kokontis J, Acakpo-Satchivi L, Liao S, Takeda H, Chang Y (Dec 1989). "Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains". Biochemical and Biophysical Research Communications. 165 (2): 735–41. doi:10.1016/S0006-291X(89)80028-2. PMID 2597158.
7. Mu X, Chang C (Oct 2003). "TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3". The Prostate. 57 (2): 129–33. doi:10.1002/pros.10282. PMID 12949936. S2CID 24134119.
8. Hu YC, Shyr CR, Che W, Mu XM, Kim E, Chang C (Sep 2002). "Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor". The Journal of Biological Chemistry. 277 (37): 33571–9. doi:10.1074/jbc.M203531200. PMID 12093804.
9. Li G, Franco PJ, Wei LN (Oct 2003). "Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2". Biochemical and Biophysical Research Communications. 310 (2): 384–90. doi:10.1016/j.bbrc.2003.08.145. PMID 14521922.
10. Franco PJ, Li G, Wei LN (Aug 2003). "Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase". Molecular and Cellular Endocrinology. 206 (1–2): 1–12. doi:10.1016/S0303-7207(03)00254-5. PMID 12943985. S2CID 19487189.
11. Franco PJ, Farooqui M, Seto E, Wei LN (Aug 2001). "The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases". Molecular Endocrinology. 15 (8): 1318–28. doi:10.1210/mend.15.8.0682. PMID 11463856.

Further reading

• Chang C, Kokontis J (Sep 1988). "Identification of a new member of the steroid receptor super-family by cloning and sequence analysis". Biochemical and Biophysical Research Communications. 155 (2): 971–7. doi:10.1016/S0006-291X(88)80591-6. PMID 3421977.
• Lin DL, Wu SQ, Chang C (Apr 1998). "The genomic structure and chromosomal location of the human TR2 orphan receptor, a member of the steroid receptor superfamily". Endocrine. 8 (2): 123–34. doi:10.1385/ENDO:8:2:123. PMID 9704569. S2CID 23712655.
• Lee CH, Chinpaisal C, Wei LN (Sep 1998). "A novel nuclear receptor heterodimerization pathway mediated by orphan receptors TR2 and TR4". The Journal of Biological Chemistry. 273 (39): 25209–15. doi:10.1074/jbc.273.39.25209. PMID 9737983.
• Lee CH, Chinpaisal C, Wei LN (Nov 1998). "Cloning and characterization of mouse RIP140, a corepressor for nuclear orphan receptor TR2". Molecular and Cellular Biology. 18 (11): 6745–55. doi:10.1128/mcb.18.11.6745. PMC 109258. PMID 9774688.
• Yu Z, Lee CH, Chinpaisal C, Wei LN (Oct 1998). "A constitutive nuclear localization signal from the second zinc-finger of orphan nuclear receptor TR2". The Journal of Endocrinology. 159 (1): 53–60. doi:10.1677/joe.0.1590053. PMID 9795341.
• Franco PJ, Farooqui M, Seto E, Wei LN (Aug 2001). "The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases". Molecular Endocrinology. 15 (8): 1318–28. doi:10.1210/mend.15.8.0682. PMID 11463856.
• Tanabe O, Katsuoka F, Campbell AD, Song W, Yamamoto M, Tanimoto K, Engel JD (Jul 2002). "An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer". The EMBO Journal. 21 (13): 3434–42. doi:10.1093/emboj/cdf340. PMC 126089. PMID 12093744.
• Hu YC, Shyr CR, Che W, Mu XM, Kim E, Chang C (Sep 2002). "Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor". The Journal of Biological Chemistry. 277 (37): 33571–9. doi:10.1074/jbc.M203531200. PMID 12093804.
• Inui S, Lee YF, Chang E, Shyr CR, Chang C (Feb 2003). "Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes". Journal of Dermatological Science. 31 (1): 65–71. doi:10.1016/S0923-1811(02)00152-4. PMID 12615366.
• Franco PJ, Li G, Wei LN (Aug 2003). "Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase". Molecular and Cellular Endocrinology. 206 (1–2): 1–12. doi:10.1016/S0303-7207(03)00254-5. PMID 12943985. S2CID 19487189.
• Mu X, Chang C (Oct 2003). "TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3". The Prostate. 57 (2): 129–33. doi:10.1002/pros.10282. PMID 12949936. S2CID 24134119.
• Li G, Franco PJ, Wei LN (Oct 2003). "Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2". Biochemical and Biophysical Research Communications. 310 (2): 384–90. doi:10.1016/j.bbrc.2003.08.145. PMID 14521922.
• Lin YL, Wang YH, Lee HJ (Nov 2006). "Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A". Biochemical and Biophysical Research Communications. 350 (2): 430–6. doi:10.1016/j.bbrc.2006.09.061. PMID 17010934.