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HES2
Identifiers
Aliases	HES2, bHLHb40, hes family bHLH transcription factor 2
External IDs	OMIM: 609970; MGI: 1098624; HomoloGene: 22455; GeneCards: HES2; OMA:HES2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	6,424,670 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	152,246,926 bp
RNA expression pattern
	Top expressed in
	mucosa of esophagus; ; mucosa of transverse colon; ; buccal mucosa cell; ; placenta; ; skin of abdomen; ; gingival epithelium; ; skin of leg; ; vagina; ; right uterine tube; ; olfactory zone of nasal mucosa;
	Top expressed in
	embryo; ; lip; ; jejunum; ; right kidney; ; proximal tubule; ; duodenum; ; yolk sac; ; Ileal epithelium; ; esophagus; ; lens;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; double-stranded DNA binding; transcription factor binding; protein dimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding; transcription corepressor activity; sequence-specific DNA binding; sequence-specific double-stranded DNA binding;
Cellular component	nucleus;
Biological process	negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; somitogenesis; Notch signaling pathway; cell differentiation; regulation of neurogenesis; anterior/posterior pattern specification;
	Sources:Amigo / QuickGO
Orthologs
	54626
	15206
	ENSG00000069812
	ENSMUSG00000028940
	Q9Y543
	O54792
	NM_019089
	NM_001301805; NM_008236
	NP_061962
	NP_001288734; NP_032262
	Wikidata
View/Edit Human	View/Edit Mouse

Hes family bHLH transcription factor 2 is a protein that in humans is encoded by the HES2 gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000069812 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028940 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Hes family bHLH transcription factor 2".

Nishimura M, Isaka F, Ishibashi M, Tomita K, Tsuda H, Nakanishi S, Kageyama R (April 1998). "Structure, chromosomal locus, and promoter of mouse Hes2 gene, a homologue of Drosophila hairy and Enhancer of split". Genomics. 49 (1): 69–75. doi:10.1006/geno.1998.5213. PMID 9570950.
Katoh M, Katoh M (August 2004). "Identification and characterization of human HES2, HES3, and HES5 genes in silico". International Journal of Oncology. 25 (2): 529–34. doi:10.3892/ijo.25.2.529. PMID 15254753.
Katoh M, Katoh M (August 2007). "Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer". International Journal of Oncology. 31 (2): 461–6. doi:10.3892/ijo.31.2.461. PMID 17611704.