CD120

tumor necrosis factor receptor superfamily, member 1A
Identifiers
Symbol	TNFRSF1A
Alt. symbols	CD120a, TNFR1
NCBI gene	7132
HGNC	11916
OMIM	191190
RefSeq	NM_001065
UniProt	P19438
Other data
Locus	Chr. 12 p13.2
Search for Structures Swiss-model Domains InterPro

tumor necrosis factor receptor superfamily, member 1B
Identifiers
Symbol	TNFRSF1B
Alt. symbols	CD120a, TNFR2
NCBI gene	7133
HGNC	11917
OMIM	191191
RefSeq	NM_001066
UniProt	P20333
Other data
Locus	Chr. 1 p36.22
Search for Structures Swiss-model Domains InterPro

CD120 (Cluster of Differentiation 120) can refer to two members of the tumor necrosis factor receptor superfamily: tumor necrosis factor receptor 1 (TNFR1) and tumor necrosis factor receptor 2 (TNFR2).^[1][2]

Receptor subtypes

There are two variants of the receptor, each encoded by a separate gene:

• CD120a - TNFR1 - TNFR superfamily member 1A
• CD120b - TNFR2 - TNFR superfamily member 1B

TNFR1 is the receptor type responsible for mediation of TNF-alpha induced sickness behavior,^[3] and is involved in neurotoxic processes.^[4] Elevated levels of TNFR1 has been found in severe mental disorders.^[5]

Signaling pathway

Signaling pathway of TNF-R1. Dashed grey lines represent multiple steps

See also

• Cluster of differentiation

References

1. Locksley RM, Killeen N, Lenardo MJ (2001). "The TNF and TNF receptor superfamilies: integrating mammalian biology". Cell. 104 (4): 487–501. doi:10.1016/S0092-8674(01)00237-9. PMID 11239407. S2CID 7657797.
2. Hehlgans T, Pfeffer K (2005). "The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games". Immunology. 115 (1): 1–20. doi:10.1111/j.1365-2567.2005.02143.x. PMC 1782125. PMID 15819693.
3. Palin K, Bluthé RM, McCusker RH, Levade T, Moos F, Dantzer R, Kelley KW (January 2009). "The type 1 TNF receptor and its associated adapter protein, FAN, are required for TNFalpha-induced sickness behavior". Psychopharmacology. 201 (4): 549–56. doi:10.1007/s00213-008-1331-4. PMC 2711641. PMID 18825372.
4. McCoy MK, Tansey MG (2008). "TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease". J Neuroinflammation. 5 (1): 45. doi:10.1186/1742-2094-5-45. PMC 2577641. PMID 18925972.
5. Hope S, Melle I, Aukrust P, Steen NE, Birkenaes AB, Lorentzen S, Agartz I, Ueland T, Andreassen OA (November 2009). "Similar immune profile in bipolar disorder and schizophrenia: selective increase in soluble tumor necrosis factor receptor I and von Willebrand factor". Bipolar Disord. 11 (7): 726–34. doi:10.1111/j.1399-5618.2009.00757.x. hdl:10852/34620. PMID 19839997.

External links

• CD120a+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• CD120b+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)