IFNA10

IFNA10
Identifiers
Aliases	IFNA10, IFN-alphaC, interferon, alpha 10, interferon alpha 10
External IDs	OMIM: 147577; MGI: 2667155; HomoloGene: 136753; GeneCards: IFNA10; OMA:IFNA10 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p21.3 Start 21,206,181 bp[1] End 21,207,143 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 C4|4 42.02 cM Start 88,561,878 bp[2] End 88,562,696 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in brain prefrontal cortex blood cerebral cortex multicellular organism Top expressed in embryo embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine activity type I interferon receptor binding cytokine receptor binding Cellular component extracellular region extracellular space Biological process natural killer cell activation involved in immune response B cell differentiation defense response B cell proliferation blood coagulation positive regulation of peptidyl-serine phosphorylation of STAT protein humoral immune response adaptive immune response defense response to virus type I interferon signaling pathway response to exogenous dsRNA T cell activation involved in immune response innate immune response cytokine-mediated signaling pathway regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3446 230396 Ensembl ENSG00000186803 ENSMUSG00000063376 UniProt P01566 Q80SU4 RefSeq (mRNA) NM_002171 NM_177347 RefSeq (protein) NP_002162 NP_796321 Location (UCSC) Chr 9: 21.21 – 21.21 Mb Chr 4: 88.56 – 88.56 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interferon alpha-10 is a protein that in humans is encoded by the IFNA10 gene.^[5][6]

References

1. GRCh38: Ensembl release 89: ENSG00000186803 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000063376 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (Dec 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics. 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID 1385305.
6. "Entrez Gene: IFNA10 interferon, alpha 10".

Further reading

• Bartholomew C, Windass JD (1989). "Identification of a functional allele of a human interferon-alpha gene previously characterized as a pseudogene". J. Interferon Res. 9 (4): 407–17. doi:10.1089/jir.1989.9.407. PMID 2526839.
• Henco K, Brosius J, Fujisawa A, et al. (1985). "Structural relationship of human interferon alpha genes and pseudogenes". J. Mol. Biol. 185 (2): 227–60. doi:10.1016/0022-2836(85)90401-2. PMID 4057246.
• Goeddel DV, Leung DW, Dull TJ, et al. (1981). "The structure of eight distinct cloned human leukocyte interferon cDNAs". Nature. 290 (5801): 20–6. Bibcode:1981Natur.290...20G. doi:10.1038/290020a0. PMID 6163083. S2CID 1900300.
• Ullrich A, Gray A, Goeddel DV, Dull TJ (1982). "Nucleotide sequence of a portion of human chromosome 9 containing a leukocyte interferon gene cluster". J. Mol. Biol. 156 (3): 467–86. doi:10.1016/0022-2836(82)90261-3. PMID 6181262.
• Fuke M, Hendrix LC, Bollon AP (1985). "Pseudogene IFN-alpha L: removal of the stop codon in the signal sequence permits expression of active human interferon". Gene. 32 (1–2): 135–40. doi:10.1016/0378-1119(84)90041-6. PMID 6397400.
• Tiefenbrun N, Melamed D, Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7): 3934–44. doi:10.1128/MCB.16.7.3934. PMC 231390. PMID 8668211.
• Nyman TA, Tölö H, Parkkinen J, Kalkkinen N (1998). "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes". Biochem. J. 329 (2): 295–302. doi:10.1042/bj3290295. PMC 1219044. PMID 9425112.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.