Glutamyl aminopeptidase

glutamyl aminopeptidase (aminopeptidase A)
Identifiers
Symbol	ENPEP
Alt. symbols	gp160, CD249
NCBI gene	2028
HGNC	3355
OMIM	138297
RefSeq	NM_001977
UniProt	Q07075
Other data
EC number	3.4.11.7
Locus	Chr. 4 q25
Search for Structures Swiss-model Domains InterPro

Glutamyl aminopeptidase (EC 3.4.11.7, aminopeptidase A, aspartate aminopeptidase, angiotensinase A, glutamyl peptidase, Ca²⁺-activated glutamate aminopeptidase, membrane aminopeptidase II, antigen BP-1/6C3 of mouse B lymphocytes, L-aspartate aminopeptidase, angiotensinase A2) is an enzyme encoded by the ENPEP gene. Glutamyl aminopeptidase has also recently been designated CD249 (cluster of differentiation 249).

Glutamyl aminopeptidase is a zinc-dependent membrane-bound aminopeptidase that catalyzes the cleavage of glutamatic and aspartatic amino acid residues from the N-terminus of polypeptides. The enzyme degrades vasoconstricting angiotensin II into angiotensin III and therefore helps to regulate blood pressure.^[1]

References

1. Reaux A, Iturrioz X, Vazeux G, Fournie-Zaluski MC, David C, Roques BP, Corvol P, Llorens-Cortes C (2000). "Aminopeptidase A, which generates one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, has a key role in central control of arterial blood pressure". Biochem. Soc. Trans. 28 (4): 435–40. doi:10.1042/0300-5127:0280435. PMID 10961935.

External links

• The MEROPS online database for peptidases and their inhibitors: M01.003
• Glutamyl+aminopeptidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)