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ART4
Identifiers
Aliases	ART4, ARTC4, CD297, DO, DOK1, ADP-ribosyltransferase 4 (Dombrock blood group), DO/ADP-ribosyltransferase 4 (inactive) (Dombrock blood group)
External IDs	OMIM: 110600; MGI: 1202710; HomoloGene: 10883; GeneCards: ART4; OMA:ART4 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	14,843,526 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	136,834,731 bp
RNA expression pattern
	Top expressed in
	liver; ; right lobe of liver; ; right coronary artery; ; right auricle; ; thoracic aorta; ; ascending aorta; ; gallbladder; ; Descending thoracic aorta; ; left coronary artery; ; trabecular bone;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; interventricular septum; ; lacrimal gland; ; lumbar spinal ganglion; ; right lobe of liver; ; embryo; ; myocardium of ventricle; ; thymus; ; blastocyst; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; NAD+-protein-arginine ADP-ribosyltransferase activity; glycosyltransferase activity; NAD+ ADP-ribosyltransferase activity;
Cellular component	anchored component of membrane; membrane; extracellular region; plasma membrane;
Biological process	protein ADP-ribosylation; arginine metabolic process; peptidyl-arginine ADP-ribosylation;
	Sources:Amigo / QuickGO
Orthologs
	420
	109978
	ENSG00000111339
	ENSMUSG00000030217
	Q93070
	Q9CRA0
	NM_021071; NM_001354646
	NM_026639
	NP_066549; NP_001341575
	NP_080915
	Wikidata
View/Edit Human	View/Edit Mouse

Ecto-ADP-ribosyltransferase 4 is an enzyme that in humans is encoded by the ART4 gene.^[5]^[6] ART4 has also been designated as CD297 (cluster of differentiation 297).

Function

This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinositol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known.^[6]

Blood group antigens

Several antigens have been recognised in this family. These are DO*A, DO*JO1, DO*A-WL, DO*DOYA, DO*B, DO*B-WL, DO*B-SH-Q149K, DO*B-(WL)-I175N, DO*HY1, DO*HY2 and DO*DOMR.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000111339 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030217 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Koch-Nolte F, Haag F, Braren R, Kühl M, Hoovers J, Balasubramanian S, Bazan F, Thiele HG (Feb 1997). "Two novel human members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxins". Genomics. 39 (3): 370–6. doi:10.1006/geno.1996.4520. PMID 9119374.
^ ^a ^b "Entrez Gene: ART4 ADP-ribosyltransferase 4 (Dombrock blood group)".

External links

ART4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human ART4 genome location and ART4 gene details page in the UCSC Genome Browser.
Human DOK1 genome location and DOK1 gene details page in the UCSC Genome Browser.
Dombrock blood group antigen NCBI Blood Group Antigen Gene Mutation Database