CD302

CD302
Identifiers
Aliases	CD302, BIMLEC, CLEC13A, DCL-1, DCL1, CD302 molecule
External IDs	OMIM: 612246; MGI: 1913455; HomoloGene: 8919; GeneCards: CD302; OMA:CD302 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q24.2 Start 159,768,628 bp[1] End 159,798,255 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 C1.1 Start 60,082,337 bp[2] End 60,114,832 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lower lobe of lung monocyte right lung liver synovial joint trabecular bone synovial membrane right lobe of liver Achilles tendon superficial temporal artery Top expressed in left lobe of liver white adipose tissue calvaria stroma of bone marrow right kidney tunica adventitia of aorta right lung lobe mesenteric lymph nodes carotid body skin of external ear More reference expression data BioGPS n/a
Gene ontology Molecular function carbohydrate binding transmembrane signaling receptor activity Cellular component filopodium cytoplasm integral component of membrane microvillus cell projection cell cortex membrane integral component of plasma membrane Biological process phagocytosis signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9936 66205 Ensembl ENSG00000241399 ENSMUSG00000060703 UniProt Q8IX05 Q9DCG2 RefSeq (mRNA) NM_014880 NM_001198763 NM_001198764 NM_001290660 NM_025422 RefSeq (protein) NP_001185692 NP_001185693 NP_055695 NP_001277589 NP_079698 Location (UCSC) Chr 2: 159.77 – 159.8 Mb Chr 2: 60.08 – 60.11 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The CD302 antigen also known as C-type lectin domain family 13 member A is a protein that in humans is encoded by the CD302 gene.^[5][6]

Function

CD302 is a C-type lectin receptor involved in cell adhesion and migration, as well as endocytosis and phagocytosis.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000241399 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060703 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1994). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
6. Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1994). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
7. Kato M, Khan S, d'Aniello E, McDonald KJ, Hart DN (November 2007). "The novel endocytic and phagocytic C-Type lectin receptor DCL-1/CD302 on macrophages is colocalized with F-actin, suggesting a role in cell adhesion and migration". J. Immunol. 179 (9): 6052–63. doi:10.4049/jimmunol.179.9.6052. PMID 17947679.

External links

• Human CD302 genome location and CD302 gene details page in the UCSC Genome Browser.

Further reading

• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yang S, Noble CG, Yang D (2009). "Characterization of DLC1-SAM equilibrium unfolding at the amino acid residue level". Biochemistry. 48 (19): 4040–9. doi:10.1021/bi9000936. PMID 19317456.
• Kato M, Khan S, Gonzalez N, et al. (2003). "Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1". J. Biol. Chem. 278 (36): 34035–41. doi:10.1074/jbc.M303112200. PMID 12824192.
• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.