RARG

RARG
Наявні структури
PDBПошук ортологів: H3BMH6 PDBe H3BMH6 RCSB
Ідентифікатори
Символи RARG, NR1B3, RARC, retinoic acid receptor gamma, RARgamma
Зовнішні ІД OMIM: 180190 MGI: 97858 HomoloGene: 20263 GeneCards: RARG
Реагує на сполуку
adapalene, alitretinoin, palovarotene, tamibarotene, tazarotene, третиноїн[1]
Ортологи
Види Людина Миша
Entrez
Ensembl
UniProt
RefSeq (мРНК)
NM_000966
NM_001042728
NM_001243730
NM_001243731
NM_001243732
NM_001042727
NM_011244
RefSeq (білок)
NP_000957
NP_001036193
NP_001230659
NP_001230660
NP_001230661
NP_001036192
NP_035374
Локус (UCSC) Хр. 12: 53.21 – 53.23 Mb Хр. 15: 102.14 – 102.17 Mb
PubMed search [2] [3]
Вікідані
Див./Ред. для людейДив./Ред. для мишей

RARG (англ. Retinoic acid receptor gamma) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 12-ї хромосоми.[4] Довжина поліпептидного ланцюга білка становить 454 амінокислот, а молекулярна маса — 50 342[5].

Послідовність амінокислот
1020304050
MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLG
QPDLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGY
HYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKC
FEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQET
FPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPG
FTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMH
NAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKV
DKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITL
KMEIPGPMPPLIREMLENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGL
KSPA

Кодований геном білок за функцією належить до рецепторів. Задіяний у таких біологічних процесах, як транскрипція, регуляція транскрипції, альтернативний сплайсинг. Білок має сайт для зв'язування з іонами металів, іоном цинку, ДНК. Локалізований у ядрі.

Література

  • Krust A., Kastner P., Petkovich M., Zelent A., Chambon P. (1989). A third human retinoic acid receptor, hRAR-gamma. Proc. Natl. Acad. Sci. U.S.A. 86: 5310—5314. PMID 2546152 DOI:10.1073/pnas.86.14.5310
  • Lehmann J.M., Hoffmann B., Pfahl M. (1991). Genomic organization of the retinoic acid receptor gamma gene. Nucleic Acids Res. 19: 573—578. PMID 1849262 DOI:10.1093/nar/19.3.573
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
  • Lehmann J.M., Zhang X.K., Pfahl M. (1992). RAR-gamma-2 expression is regulated through a retinoic acid response element embedded in Sp1 sites. Mol. Cell. Biol. 12: 2976—2985. PMID 1320193 DOI:10.1128/MCB.12.7.2976

Примітки

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