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比西发定

比西发定
臨床資料
给药途径口服
ATC碼
  • 未分配
法律規範狀態
法律規範
  • 未列入管制
藥物動力學數據
生物半衰期1.6 hours
排泄途徑renal
识别信息
  • 1-(4-Methylphenyl)-3-azabicyclo[3.1.0]hexane
CAS号71195-57-8  checkY
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.124.957 編輯維基數據鏈接
化学信息
化学式C12H15N
摩尔质量173.26 g·mol−1
3D模型(JSmol英语JSmol
  • c1cc(ccc1C)[C@]32CNC[C@@H]2C3
  • InChI=1S/C12H15N/c1-9-2-4-10(5-3-9)12-6-11(12)7-13-8-12/h2-5,11,13H,6-8H2,1H3/t11-,12+/m0/s1 checkY
  • Key:OFYVIGTWSQPCLF-NWDGAFQWSA-N checkY

比西发定(英語:Bicifadine,开发代号:DOV-220,075)是一种含氮有机化合物,分子式C12H15N,可用作5-羟色胺、去甲肾上腺素和多巴胺再摄取抑制剂(SNDRI),由美国氰胺公司英语American Cyanamid作为镇痛药开发,在其被惠氏收购后交由DOV制药英语DOV Pharmaceutical[1][2][3]

参考文献

  1. ^ Marks DM, Pae CU, Patkar AA. Triple reuptake inhibitors: a premise and promise. Psychiatry Investigation. September 2008, 5 (3): 142–7. PMC 2796030可免费查阅. PMID 20046357. doi:10.4306/pi.2008.5.3.142. 
  2. ^ SEC Filing: Wyeth-DOV Restated License Agreement Page accessed July 15, 2015]
  3. ^ Neubauer DN. Indiplon. Monti JM, Pandi-Perumal SR, Möhler H (编). GABA and Sleep: Molecular, Functional and Clinical Aspects. Springer Science & Business Media. 2010: 453––464. ISBN 9783034602266. 

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