MYO1E

MYO1E
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XMF
Identifiers
Aliases	MYO1E, FSGS6, HuncM-IC, MYO1C, myosin IE
External IDs	OMIM: 601479; MGI: 106621; HomoloGene: 55864; GeneCards: MYO1E; OMA:MYO1E - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q22.2 Start 59,132,434 bp[1] End 59,372,871 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 D|9 39.41 cM Start 70,114,632 bp[2] End 70,307,048 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon sural nerve gallbladder tibial arteries rectum stromal cell of endometrium skin of leg Descending thoracic aorta mucosa of transverse colon ascending aorta Top expressed in lumbar spinal ganglion mesenteric lymph nodes calvaria left colon lip cumulus cell tail of embryo duodenum epithelium of stomach lacrimal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding calmodulin binding actin filament binding microfilament motor activity protein binding phosphatidylinositol binding actin binding cytoskeletal motor activity ATP binding lipid binding Cellular component cytoplasm cell-cell junction clathrin-coated endocytic vesicle adherens junction cell junction brush border actin cytoskeleton extracellular exosome cytoskeleton cytoplasmic vesicle clathrin-coated vesicle myosin complex Biological process hemopoiesis endocytosis glomerular visceral epithelial cell development glomerular basement membrane development kidney development post-embryonic hemopoiesis in utero embryonic development actin filament-based movement vasculogenesis nitrogen compound metabolic process glomerular filtration platelet-derived growth factor receptor signaling pathway metabolism Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4643 71602 Ensembl ENSG00000157483 ENSMUSG00000032220 UniProt Q12965 E9Q634 RefSeq (mRNA) NM_004998 NM_181072 NM_025612 RefSeq (protein) NP_004989 NP_851417 Location (UCSC) Chr 15: 59.13 – 59.37 Mb Chr 9: 70.11 – 70.31 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Myosin-Ie (Myo1e) is a protein that in humans is encoded by the MYO1E gene.^[5][6]

Myosin-Ie is a long tailed myosin. It contains an N-terminal motor domain, an IQ motif, a TH1 domain containing a plecstrin homology (PH) domain, a proline rich TH2 domain, and an SH3 domain. ^[7]

The MYO1E gene was included in several genetic signatures for cancer prognosis.^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000157483 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032220 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, et al. (September 1996). "Mapping of unconventional myosins in mouse and human". Genomics. 36 (3): 431–439. doi:10.1006/geno.1996.0488. PMID 8884266.
6. "Entrez Gene: MYO1E myosin IE".
7. McConnell RE, Tyska MJ (July 2010). "Leveraging the membrane - cytoskeleton interface with myosin-1". Trends in Cell Biology. 20 (7): 418–426. doi:10.1016/j.tcb.2010.04.004. PMC 2897960. PMID 20471271.
8. Chicco D, Alameer A, Rahmati S, Jurman G (November 2022). "Towards a potential pan-cancer prognostic signature for gene expression based on probesets and ensemble machine learning". BioData Mining. 15 (1): 28. doi:10.1186/s13040-022-00312-y. eISSN 1756-0381. PMC 9632055. PMID 36329531.

Further reading

• Krendel M, Osterweil EK, Mooseker MS (February 2007). "Myosin 1E interacts with synaptojanin-1 and dynamin and is involved in endocytosis". FEBS Letters. 581 (4): 644–650. doi:10.1016/j.febslet.2007.01.021. PMC 1861834. PMID 17257598.
• El Mezgueldi M, Tang N, Rosenfeld SS, Ostap EM (June 2002). "The kinetic mechanism of Myo1e (human myosin-IC)". The Journal of Biological Chemistry. 277 (24): 21514–21521. doi:10.1074/jbc.M200713200. PMID 11940582.
• Skowron JF, Bement WM, Mooseker MS (1999). "Human brush border myosin-I and myosin-Ic expression in human intestine and Caco-2BBe cells". Cell Motility and the Cytoskeleton. 41 (4): 308–324. doi:10.1002/(SICI)1097-0169(1998)41:4<308::AID-CM4>3.0.CO;2-J. PMID 9858156.
• Robertson H, Langdon WY, Thien CB, Bowtell DD (November 1997). "A c-Cbl yeast two hybrid screen reveals interactions with 14-3-3 isoforms and cytoskeletal components". Biochemical and Biophysical Research Communications. 240 (1): 46–50. doi:10.1006/bbrc.1997.7608. PMID 9367879.
• Bement WM, Hasson T, Wirth JA, Cheney RE, Mooseker MS (July 1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types". Proceedings of the National Academy of Sciences of the United States of America. 91 (14): 6549–6553. Bibcode:1994PNAS...91.6549B. doi:10.1073/pnas.91.14.6549. PMC 44240. PMID 8022818.
• Bement WM, Wirth JA, Mooseker MS (October 1994). "Cloning and mRNA expression of human unconventional myosin-IC. A homologue of amoeboid myosins-I with a single IQ motif and an SH3 domain". Journal of Molecular Biology. 243 (2): 356–363. doi:10.1006/jmbi.1994.1662. PMID 7932763.

External links

• Overview of all the structural information available in the PDB for UniProt: E9Q634 (Mouse Unconventional myosin-Ie) at the PDBe-KB.