KIF9

KIF9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3NWN
Identifiers
Aliases	KIF9, kinesin family member 9
External IDs	OMIM: 607910; MGI: 1098237; HomoloGene: 65620; GeneCards: KIF9; OMA:KIF9 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 47,227,998 bp[1] End 47,283,451 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F2 Start 110,306,026 bp[2] End 110,354,247 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell sperm caput epididymis left testis mucosa of paranasal sinus right testis right uterine tube olfactory zone of nasal mucosa tendon of biceps brachii corpus epididymis Top expressed in spermatid spermatocyte seminiferous tubule olfactory epithelium choroid plexus of lateral ventricle choroid plexus of fourth ventricle Epithelium of choroid plexus vestibular sensory epithelium oocyte primary oocyte More reference expression data BioGPS n/a
Gene ontology Molecular function protein dimerization activity nucleotide binding microtubule motor activity protein binding microtubule binding ATP binding ATPase activity Cellular component cytoskeleton vesicle podosome cytoplasm kinesin complex microtubule Biological process extracellular matrix disassembly regulation of podosome assembly organelle disassembly microtubule-based movement Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64147 16578 Ensembl ENSG00000088727 ENSMUSG00000032489 UniProt Q9HAQ2 Q6PJI1 Q9WV04 RefSeq (mRNA) NM_001134878 NM_022342 NM_182902 NM_182903 NM_001377474 NM_001377475 NM_001377476 NM_001377477 NM_001163569 NM_010628 RefSeq (protein) NP_001128350 NP_071737 NP_878905 NP_001364403 NP_001364404 NP_001364405 NP_001364406 NP_001157041 NP_034758 Location (UCSC) Chr 3: 47.23 – 47.28 Mb Chr 9: 110.31 – 110.35 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Kinesin family member 9 (KIF9), also known as kinesin-9, is a human protein encoded by the KIF9 gene. It is part of the kinesin family of motor proteins.

Function

The beating of the flagella in sperm is regulated by KIF9 activity.^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000088727 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032489 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Miyata H, Shimada K, Morohoshi A, Oura S, Matsumura T, Xu Z, et al. (April 2020). "Testis-enriched kinesin KIF9 is important for progressive motility in mouse spermatozoa". FASEB Journal. 34 (4): 5389–5400. doi:10.1096/fj.201902755R. PMC 7136151. PMID 32072696.