MYLIP

MYLIP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YHN, 2YHO
Identifiers
Aliases	MYLIP, IDOL, MIR, myosin regulatory light chain interacting protein
External IDs	OMIM: 610082; MGI: 2388271; HomoloGene: 8309; GeneCards: MYLIP; OMA:MYLIP - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.3 Start 16,129,086 bp[1] End 16,148,248 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A5 Start 45,543,218 bp[2] End 45,565,498 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte nipple lower lobe of lung lactiferous duct synovial joint renal medulla saphenous vein urethra cardia Top expressed in calvaria lymph node transitional epithelium of urinary bladder ciliary body tibiofemoral joint parotid gland sciatic nerve mesenteric lymph nodes skin of external ear iris More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding cytoskeletal protein binding protein binding ubiquitin-protein transferase activity structural constituent of cytoskeleton transferase activity ubiquitin protein ligase activity Cellular component cytoplasm membrane plasma membrane intracellular anatomical structure cytosol cytoskeleton Biological process positive regulation of protein catabolic process negative regulation of low-density lipoprotein particle clearance regulation of low-density lipoprotein particle receptor catabolic process nervous system development protein destabilization protein ubiquitination cholesterol homeostasis protein polyubiquitination actomyosin structure organization low-density lipoprotein particle receptor catabolic process negative regulation of neuron projection development ubiquitin-dependent protein catabolic process cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29116 218203 Ensembl ENSG00000007944 ENSMUSG00000038175 UniProt Q8WY64 Q8BM54 RefSeq (mRNA) NM_013262 NM_153789 RefSeq (protein) NP_037394 NP_722484 Location (UCSC) Chr 6: 16.13 – 16.15 Mb Chr 13: 45.54 – 45.57 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Myosin regulatory light chain interacting protein, also known as MYLIP, is a protein that in humans is encoded by the MYLIP gene.^[5]

MYLIP is also known as IDOL "Inducible Degrader of the LDL receptor" based on its involvement in cholesterol regulation or MIR "Modulator Of Immune Recognition".^[6][7] The expression of IDOL is induced by the sterol-activated liver X receptor.

Increased Degradation of LDL Receptor Protein (IDOL) is a ubiquitin ligase that ubiquinates LDL receptors in endosomes and directs the receptors to the lysosomal compartment for degradation. IDOL is transcriptionally up-regulated by LXR/RXR in response to an increase in intracellular cholesterol.^[8] Pharmacologic inhibition of IDOL could reduce plasma LDL cholesterol by increasing plasma LDL receptor density.

Function

The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth.^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000007944 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038175 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: MYLIP myosin regulatory light chain interacting protein".
6. Zelcer N, Hong C, Boyadjian R, Tontonoz P (July 2009). "LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor". Science. 325 (5936): 100–4. Bibcode:2009Sci...325..100Z. doi:10.1126/science.1168974. PMC 2777523. PMID 19520913.
7. Lindholm D, Bornhauser BC, Korhonen L (November 2009). "Mylip makes an Idol turn into regulation of LDL receptor". Cell. Mol. Life Sci. 66 (21): 3399–402. doi:10.1007/s00018-009-0127-y. PMC 11115883. PMID 19688294. S2CID 34153384.
8. Sawamura, T. (2009). "New Idol for cholesterol reduction?". Clin. Chem. 55 (12): 2082–2084. doi:10.1373/clinchem.2009.134023. PMID 19833835.

Further reading

• Olsson PA, Korhonen L, Mercer EA, Lindholm D (2000). "MIR is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth". J. Biol. Chem. 274 (51): 36288–92. doi:10.1074/jbc.274.51.36288. PMID 10593918.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Olsson PA, Bornhauser BC, Korhonen L, Lindholm D (2001). "Neuronal expression of the ERM-like protein MIR in rat brain and its localization to human chromosome 6". Biochem. Biophys. Res. Commun. 279 (3): 879–83. doi:10.1006/bbrc.2000.4028. PMID 11162443.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bornhauser BC, Olsson PA, Lindholm D (2003). "MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain". J. Biol. Chem. 278 (37): 35412–20. doi:10.1074/jbc.M306271200. PMID 12826659.
• Bornhauser BC, Johansson C, Lindholm D (2003). "Functional activities and cellular localization of the ezrin, radixin, moesin (ERM) and RING zinc finger domains in MIR". FEBS Lett. 553 (1–2): 195–9. doi:10.1016/S0014-5793(03)01010-X. PMID 14550572. S2CID 25599548.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Ohmura-Hoshino M, Matsuki Y, Aoki M, et al. (2006). "Inhibition of MHC class II expression and immune responses by c-MIR". J. Immunol. 177 (1): 341–54. doi:10.4049/jimmunol.177.1.341. PMID 16785530.