MYL6B

MYL6B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1OE9, 1W7I, 1W7J
Identifiers
Aliases	MYL6B, MLC1SA, myosin light chain 6B
External IDs	OMIM: 609930; MGI: 1917789; HomoloGene: 86887; GeneCards: MYL6B; OMA:MYL6B - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.2 Start 56,152,256 bp[1] End 56,159,647 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D3 Start 128,330,026 bp[2] End 128,334,554 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in glutes Skeletal muscle tissue of biceps brachii muscle of thigh thoracic diaphragm ganglionic eminence tibialis anterior muscle epithelium of colon deltoid muscle left testis right testis Top expressed in thoracic diaphragm Hypothalamus genital tubercle white adipose tissue testicle ganglionic eminence tail of embryo synovial joint ankle joint muscle tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding structural constituent of muscle cytoskeletal motor activity protein binding Cellular component cytosol muscle myosin complex unconventional myosin complex extracellular exosome myosin complex Biological process muscle contraction skeletal muscle tissue development muscle filament sliding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 140465 216459 Ensembl ENSG00000196465 ENSMUSG00000039824 UniProt P14649 Q8CI43 RefSeq (mRNA) NM_002475 NM_001199629 NM_172259 RefSeq (protein) NP_001186558 NP_002466 NP_758463 Location (UCSC) Chr 12: 56.15 – 56.16 Mb Chr 10: 128.33 – 128.33 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Myosin light chain 6B is a protein that in humans is encoded by the MYL6B gene.^[5][6][7] Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in both slow-twitch skeletal muscle and in nonmuscle tissue.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000196465 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039824 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zimmermann K, Starzinski-Powitz A (Feb 1990). "A novel isoform of myosin alkali light chain isolated from human muscle cells". Nucleic Acids Res. 17 (24): 10496. doi:10.1093/nar/17.24.10496. PMC 335321. PMID 2602161.
6. Hailstones DL, Gunning PW (Mar 1990). "Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function". Mol Cell Biol. 10 (3): 1095–104. doi:10.1128/mcb.10.3.1095. PMC 360973. PMID 2304459.
7. "Entrez Gene: MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle".

Further reading

• Coureux PD, Sweeney HL, Houdusse A (2005). "Three myosin V structures delineate essential features of chemo-mechanical transduction". EMBO J. 23 (23): 4527–37. doi:10.1038/sj.emboj.7600458. PMC 533045. PMID 15510214.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Komiyama M, Soldati T, von Arx P, Perriard JC (1997). "The intracompartmental sorting of myosin alkali light chain isoproteins reflects the sequence of developmental expression as determined by double epitope-tagging competition". J. Cell Sci. 109 (8): 2089–99. doi:10.1242/jcs.109.8.2089. PMID 8856505.
• Seidel U, Bober E, Winter B, et al. (1988). "Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms". Gene. 66 (1): 135–46. doi:10.1016/0378-1119(88)90231-4. PMID 2458299.

External links

• Overview of all the structural information available in the PDB for UniProt: P14649 (Human Myosin light chain 6B (MYL6B)) at the PDBe-KB.