MYH7B

MYH7B
Identifiers
Aliases	MYH7B, MHC14, MYH14, myosin, heavy chain 7B, cardiac muscle, beta, myosin heavy chain 7B
External IDs	OMIM: 609928; MGI: 3710243; HomoloGene: 66117; GeneCards: MYH7B; OMA:MYH7B - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.22 Start 34,955,810 bp[1] End 35,002,437 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H1 Start 155,453,132 bp[2] End 155,476,227 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart muscle of thigh left ventricle right auricle of heart Skeletal muscle tissue of rectus abdominis body of tongue biceps brachii Skeletal muscle tissue of biceps brachii lateral nuclear group of thalamus sperm Top expressed in vascular smooth muscle lens neural layer of retina left ventricle soleus muscle vasculature of trunk superior frontal gyrus cerebellar cortex myocardium of atrium primary visual cortex More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding actin binding cytoskeletal motor activity protein binding ATP binding actin filament binding microtubule motor activity microtubule binding Cellular component myosin filament membrane myosin complex cardiac myofibril Biological process microtubule-based movement Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57644 668940 Ensembl ENSG00000078814 ENSMUSG00000074652 UniProt Q5JW45 A2AQP0 RefSeq (mRNA) NM_020884 NM_033424 NM_001085378 RefSeq (protein) NP_065935 NP_001078847 Location (UCSC) Chr 20: 34.96 – 35 Mb Chr 2: 155.45 – 155.48 Mb PubMed search [3] [4]
Wikidata
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Myosin-7B also known as myosin, heavy chain 7B is a protein that in humans is encoded by the MYH7B gene.^[5][6]

Function

MYH7B is a slow-twitch myosin.^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000078814 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000074652 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (April 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
6. Desjardins PR, Burkman JM, Shrager JB, Allmond LA, Stedman HH (April 2002). "Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family". Mol. Biol. Evol. 19 (4): 375–93. doi:10.1093/oxfordjournals.molbev.a004093. PMID 11919279.

Further reading

• Rossi AC, Mammucari C, Argentini C, et al. (2010). "Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b and MYH15 are expressed in extraocular muscles and muscle spindles". J. Physiol. 588 (Pt 2): 353–64. doi:10.1113/jphysiol.2009.181008. PMC 2821527. PMID 19948655.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Deloukas P, Matthews LH, Ashurst J, et al. (2001). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• McGuigan K, Phillips PC, Postlethwait JH (2004). "Evolution of sarcomeric myosin heavy chain genes: evidence from fish". Mol. Biol. Evol. 21 (6): 1042–56. doi:10.1093/molbev/msh103. PMID 15014174.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hu Z, Liang J, Wang Z, et al. (2009). "Common genetic variants in pre-microRNAs were associated with increased risk of breast cancer in Chinese women". Hum. Mutat. 30 (1): 79–84. doi:10.1002/humu.20837. PMID 18634034. S2CID 41225773.