KIF4B

KIF4B
Identifiers
Aliases	KIF4B, kinesin family member 4B
External IDs	OMIM: 609184; HomoloGene: 129673; GeneCards: KIF4B; OMA:KIF4B - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.2 Start 155,013,755 bp[1] End 155,018,141 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle left testis ventricular zone right testis n/a More reference expression data BioGPS n/a
Gene ontology Molecular function microtubule binding DNA binding nucleotide binding ATP binding plus-end-directed microtubule motor activity microtubule motor activity ATPase activity Cellular component nuclear matrix cytoplasm cytosol microtubule cytoskeleton kinesin complex nucleus nucleoplasm intercellular bridge Biological process mitotic cytokinesis microtubule-based movement antigen processing and presentation of exogenous peptide antigen via MHC class II mitotic spindle midzone assembly retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum mitotic spindle organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 285643 n/a Ensembl ENSG00000226650 n/a UniProt Q2VIQ3 n/a RefSeq (mRNA) NM_001099293 n/a RefSeq (protein) NP_001092763 n/a Location (UCSC) Chr 5: 155.01 – 155.02 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

KIF4B is a human protein encoded by the gene KIF4B. It is part of the kinesin family of motor proteins.

Function

KIF4B and the closely related protein KIF4A are essential for regulating anaphase spindle dynamics during mitosis.^[3]

References

1. GRCh38: Ensembl release 89: ENSG00000226650 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Zhu, Changjun; Zhao, Jian; Bibikova, Marina; Leverson, Joel D.; Bossy-Wetzel, Ella; Fan, Jian-Bing; Abraham, Robert T.; Jiang, Wei (July 2005). "Functional Analysis of Human Microtubule-based Motor Proteins, the Kinesins and Dyneins, in Mitosis/Cytokinesis Using RNA Interference". Molecular Biology of the Cell. 16 (7): 3187–3199. doi:10.1091/mbc.e05-02-0167. ISSN 1059-1524. PMC 1165403. PMID 15843429.