MYL1

MYL1
Identifiers
Aliases	MYL1, MLC1F, MLC3F, myosin light chain 1, MYOFTA, MLC1, MLC1/3, MLC-1
External IDs	OMIM: 160780; MGI: 97269; HomoloGene: 23194; GeneCards: MYL1; OMA:MYL1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q34 Start 210,290,150 bp[1] End 210,315,174 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C3|1 33.71 cM Start 66,963,454 bp[2] End 66,984,563 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of biceps brachii Skeletal muscle tissue of rectus abdominis body of tongue gastrocnemius muscle triceps brachii muscle muscle of thigh tibialis anterior muscle thoracic diaphragm quadriceps femoris muscle vastus lateralis muscle Top expressed in quadriceps femoris muscle skeletal muscle tissue muscle of thigh zone of skin esophagus lip white adipose tissue synovial joint ankle joint heart More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding structural constituent of muscle Cellular component contractile fiber cytosol muscle myosin complex myofibril sarcomere myosin complex Biological process muscle contraction cardiac muscle contraction muscle filament sliding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4632 17901 Ensembl ENSG00000168530 ENSMUSG00000061816 UniProt P05976 P05977 RefSeq (mRNA) NM_079422 NM_079420 NM_001113387 NM_021285 RefSeq (protein) NP_524144 NP_524146 NP_001106858 NP_067260 Location (UCSC) Chr 2: 210.29 – 210.32 Mb Chr 1: 66.96 – 66.98 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Myosin light chain 3, skeletal muscle isoform is a protein that in humans is encoded by the MYL1 gene.^[5][6][7]

Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Two transcript variants have been identified for this gene.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000168530 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000061816 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hailstones DL, Gunning PW (Mar 1990). "Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function". Mol Cell Biol. 10 (3): 1095–104. doi:10.1128/mcb.10.3.1095. PMC 360973. PMID 2304459.
6. Cohen-Haguenauer O, Barton PJ, Nguyen VC, Serero S, Gross MS, Jegou-Foubert C, de Tand MF, Robert B, Buckingham M, Frezal J (Mar 1988). "Assignment of the human fast skeletal muscle myosin alkali light chains gene (MLC1F/MLC3F) to 2q 32.1-2qter". Hum Genet. 78 (1): 65–70. doi:10.1007/BF00291237. PMID 3422212. S2CID 24782863.
7. "Entrez Gene: MYL1 myosin, light chain 1, alkali; skeletal, fast".

Further reading

• Kelly RG, Buckingham ME (2000). "Modular regulation of the MLC1F/3F gene and striated muscle diversity". Microsc. Res. Tech. 50 (6): 510–21. doi:10.1002/1097-0029(20000915)50:6<510::AID-JEMT8>3.0.CO;2-1. PMID 10998640. S2CID 26959819.
• Seidel U, Bober E, Winter B, et al. (1988). "Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms". Gene. 66 (1): 135–46. doi:10.1016/0378-1119(88)90231-4. PMID 2458299.
• Seidel U, Arnold HH (1989). "Identification of the functional promoter regions in the human gene encoding the myosin alkali light chains MLC1 and MLC3 of fast skeletal muscle". J. Biol. Chem. 264 (27): 16109–17. doi:10.1016/S0021-9258(18)71593-7. PMID 2777779.
• Seidel U, Bober E, Winter B, et al. (1987). "The complete nucleotide sequences of cDNA clones coding for human myosin light chains 1 and 3". Nucleic Acids Res. 15 (12): 4989. doi:10.1093/nar/15.12.4989. PMC 305934. PMID 3601661.
• Kontrogianni-Konstantopoulos A, Huang SC, Benz EJ (2001). "A Nonerythroid Isoform of Protein 4.1R Interacts with Components of the Contractile Apparatus in Skeletal Myofibers". Mol. Biol. Cell. 11 (11): 3805–17. doi:10.1091/mbc.11.11.3805. PMC 15038. PMID 11071908.
• Ballweber E, Galla M, Aktories K, et al. (2001). "Interaction of ADP-ribosylated actin with actin binding proteins". FEBS Lett. 508 (1): 131–5. doi:10.1016/S0014-5793(01)03040-X. PMID 11707283. S2CID 7241702.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.