Kortikotropinu slični intermedijarni peptid

Kortikotropinoliki intermedijarni peptid
Identifikatori
Simbol	POMC
NCBI gen	5443
HGNC	9201
OMIM	176830
RefSeq	NM_000939
UniProt	P01189
Ostali podaci
Lokus	Hrom. 2 p23
Pretraga za Strukture Swiss-model Domene InterPro

Općenito
Druga imena	IUPAC ime: L-arginil-L-prolil-L-valil-L-lizil-L-valil-L-tirozil-L-prolil-L-asparaginil-L-glicil-L-alanil-L-α-glutamil-L-α-aspartil-L-α-glutamil-L-seril-L-alanil-L-α-glutamil-L-alanil-L-fenilalanil-L-prolil-L-leucil-L-α-glutamil-L-fenilalanin
Molekularna formula	C112H165N27O36
CAS registarski broj	53917-42-3
Osobine^1
Molarna masa	2465,668 g/mol
^1 Gdje god je moguće korištene su SI jedinice. Ako nije drugačije naznačeno, dati podaci vrijede pri standardnim uslovima.

Kod čovjeka, genski lokus POMC je na kratkom (p) kraku hromosomu 2: pozicija 2p.23

Kortikotropinoliki intermedijarni peptid (CLIP), poznat i kao fragment adrenokortikotropnog hormona 18-39 [ACTH (18-39 )], je koji se prirodno pojavljuje kao endogeni neuropeptid sa dokosapeptidnom strukturom i sekvencom aminokiselina: Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe. CLIP nastaje kao proizvod cijepanja veza u proteolizi fadenokortikotropnog hormona (ACTH),^[1][2] što je zauzvrat produkt cijepanja proopiomelanokortina (POMC).^[3] Njegova fiziološka uloga je istraživana u različitim tkivima,^[4][5] posebno u centralnom nervnom sistemu.^{[6][7][8][9][10]}

Reference

1. Gianoulakis C, Seidah NG, Routhier R, Chrétien M (decembar 1979). "Biosynthesis and characterization of adrenocorticotropic hormone, alpha-melanocyte-stimulating hormone, and an NH2-terminal fragment of the adrenocorticotropic hormone/beta-lipotropin precursor from rat pars intermedia". The Journal of Biological Chemistry. 254 (23): 11903–6. PMID 227883. Arhivirano s originala, 15. 9. 2019. Pristupljeno 27. 8. 2020.
2. Lloyd D. Fricker (24. 7. 1991). Peptide biosynthesis and processing. CRC Press. str. 78. ISBN 978-0-8493-8852-1. Pristupljeno 25. 11. 2011.
3. Anthony W. Norman; Gerald Litwack (26. 9. 1997). Hormones. Academic Press. str. 12. ISBN 978-0-12-521441-4. Pristupljeno 25. 11. 2011.
4. Marshall JB, Kapcala LP, Manning LD, McCullough AJ (novembar 1984). "Effect of corticotropin-like intermediate lobe peptide on pancreatic exocrine function in isolated rat pancreatic lobules". The Journal of Clinical Investigation. 74 (5): 1886–9. doi:10.1172/JCI111608. PMC 425369. PMID 6209301.
5. Zaphiropoulos A, Charnay Y, Vallet P, Constantinidis J, Bouras C (januar 1991). "Immunohistochemical distribution of corticotropin-like intermediate lobe peptide (CLIP) immunoreactivity in the human brain". Brain Research Bulletin. 26 (1): 99–111. doi:10.1016/0361-9230(91)90194-O. PMID 1849784.
6. Shojiro Inoué; Shojiro Inoué (1989). Biology of sleep substances. CRC Press. str. 136. ISBN 978-0-8493-4822-8. Pristupljeno 25. 11. 2011.
7. Chastrette N, Cespuglio R, Jouvet M (februar 1990). "Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 1--Hypnogenic properties of ACTH derivatives". Neuropeptides. 15 (2): 61–74. doi:10.1016/0143-4179(90)90042-w. PMID 1981927.
8. Chastrette N, Cespuglio R, Lin YL, Jouvet M (februar 1990). "Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 2--Aminergic regulatory processes". Neuropeptides. 15 (2): 75–88. doi:10.1016/0143-4179(90)90043-x. PMID 1964203.
9. Grigoriev VV, Petrova LN, Ivanova TA, Gabreliyan AV, Serkova TP (mart 2009). "Effect of corticotropin-like intermediate lobe peptide on presynaptic and postsynaptic glutamate receptors and postsynaptic GABA receptors in rat brain". Bulletin of Experimental Biology and Medicine. 147 (3): 319–22. doi:10.1007/s10517-009-0499-x. PMID 19529852.
10. Seidenbecher T, Balschun D, Vogel D, Reymann KG (1993). "Neuronal transmission of hippocampal CA1 neurones is modulated by corticotropin-like intermediate lobe peptide [CLIP; ACTH(18-39)]". Peptides. 14 (6): 1221–4. doi:10.1016/0196-9781(93)90179-K. PMID 8134304.

Vanjski linkovi

• Corticotropin-Like Intermediate Lobe Peptide na US National Library of Medicine Medical Subject Headings (MeSH)