Rivaniklin

Rivaniklin
(IUPAC) ime
(E)-N-Metil-4-(3-piridinil)-3-buten-1-amin
Klinički podaci
Identifikatori
CAS broj 538-79-4
ATC kod nije dodeljen
PubChem[1][2] 5310967
UNII 6H35LF645A DaY
Hemijski podaci
Formula C10H14N2 
Mol. masa 162,232
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

Rivaniklin (TC-2403, RJR-2403, (E)-metanikotin) je lek koji deluje kao parcijalni agonist neuronskih nikotinskih acetilholinskih receptora. On je selektivan za α4β2 podtip. Ovaj lek ima nootropno dejstvo i originalno je razvijen kao potencijalni tretman za Alchajmerovu bolest.[3][4] Drugo dejstvo, koje je naknadno nađeno, je da inhibira produkciju Interleukina 8 i da stoga ima antiinflamatorni efekat, te je takođe razvijen za potencijalnu uptrebu u tretmanu ulcerativnog kolitisa.[5] Rivaniklin takođe deluje kao stimulant i analgetik.[6]

Reference

  1. ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ↑ Jang J, Sin KS, Park H. Synthesis of (+/-)-methyl-(1-aryl-4-pyridin-3-yl-but-3-enyl)-amines. Archives of Pharmacal Research. 2001 Dec;24(6):503-7. PMID 11794523
  4. ↑ Sapronov NS, Fedotova YO, Kuznetsova NN. Antiamnestic effect of alpha7-nicotinic receptor agonist RJR-2403 in middle-aged ovariectomized rats with Alzheimer type dementia. Bulletin of Experimental Biology and Medicine. 2006 Dec;142(6):700-2. PMID 17603674
  5. ↑ Spoettl T, Paetzel C, Herfarth H, Bencherif M, Schoelmerich J, Greinwald R, Gatto GJ, Rogler G. (E)-metanicotine hemigalactarate (TC-2403-12) inhibits IL-8 production in cells of the inflamed mucosa. International Journal of Colorectal Disease. 2007 Mar;22(3):303-12. PMID 16715250
  6. ↑ Li X, Eisenach JC. Nicotinic acetylcholine receptor regulation of spinal norepinephrine release. Anesthesiology. 2002 Jun;96(6):1450-6. PMID 12170059

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