Galamin

Galamin
(IUPAC) ime
2,2’,2’’-[benzen-1,2,3-triiltris(oksi)]tris(N,N,N-trietiletanaminijum) trijodid
Klinički podaci
AHFS/Drugs.com Internacionalno ime leka
Identifikatori
CAS broj 65-29-2
ATC kod M03AC02
PubChem[1][2] 6172
DrugBank APRD00712
ChemSpider[3] 5937
UNII Q3254X40X2 DaY
KEGG[4] D02292 DaY
ChEBI CHEBI:503442 DaY
ChEMBL[5] CHEMBL1200993 DaY
Hemijski podaci
Formula C24H45N3O3 (galamin) 
Mol. masa 891,529 g/mol (galamin trietjodid)
423,633 g/mol
(galamin)
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

Galamin trietjodid (Flaksedil) je nedepolarizirajući mišićni relaksant.[6] On deluje na aktivno mesto holinergčkog receptora u mišićima čime kompetitivno blokira prenos acetilholinskog signala.[7] Galamin trietjodid ima parasimpatolitičko dejstvo na srčani živac lutalac koji uzrokuje tahikardiju i povremeno hipertenziju. Veoma visoke doze uzrokuju otpuštanje histamina.

Galamin trietjodid se koristi za stabilizaciju mišićnih kontrakcija tokom hirurških postupaka.

Ovaj lek je razvila kompanija Daniel Bovet 1947.[8]

Reference

  1. ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  6. ↑ „Webster's Online Dictionary - Flaxedil”. Pristupljeno 15. 12. 2008. 
  7. ↑ „RxMed: Pharmaceutical Information - FLAXEDIL”. Pristupljeno 15. 12. 2008. 
  8. ↑ Raghavendra T (July 2002). „Neuromuscular blocking drugs: discovery and development”. J R Soc Med 95 (7): 363–7. DOI:10.1258/jrsm.95.7.363. PMC 1279945. PMID 12091515. [mrtav link]

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